Current standards of neuropsychological assessment in epilepsy surgery centers across Europe

Viola Lara Vogt; Marja Äikiä; Antonio del Barrio; Paul Boon; Csaba Borbély; Ema Bran; Kees Braun; Evelien Carette; Maria Clark; Judith Helen Cross; Petia Dimova; Daniel Fabo; Nikolaos Foroglou; Stefano Francione; Anna Gersamia; Antonio Gil-Nagel; Alla Guekht; Sue Harrison; Hrvoje Hecimovic; Einar Heminghyt; Edouard Hirsch; Alena Javurkova; Reetta Kälviäinen; Nicole Kavan; Anna Kelemen; Vasilios K. Kimiskidis; Margarita Kirschner; Catherine Kleitz; Teia Kobulashvili; Mary H. Kosmidis; Selin Yagci Kurtish; Mathieu Lesourd; Sofia Ljunggren; Morten Ingvar Lossius; Kristina Malmgren; Ruta Mameniskiené; Patricia Martin-Sanfilippo; Petr Marusic; Marijke Miatton; Çiğdem Özkara; Federica Pelle; Guido Rubboli; Sarah Rudebeck; Philippe Ryvlin; Monique van Schooneveld; Elisabeth Schmid; Pia Magdalena Schmidt; Margitta Seeck; Bernhard J. Steinhoff; Sara Shavel-Jessop; Oana Tarta-Arsene; Eugen Trinka; Gerd Viggedal; Anne-Sophie Wendling; Juri-Alexander Witt; Christoph Helmstaedter; the E-PILEPSY consortium

doi:10.1111/epi.13646

Current standards of neuropsychological assessment in epilepsy surgery centers across Europe

Viola Lara Vogt^*, Marja Äikiä, Antonio del Barrio, Paul Boon, Csaba Borbély, Ema Bran, Kees Braun, Evelien Carette, Maria Clark, Judith Helen Cross, Petia Dimova, Daniel Fabo, Nikolaos Foroglou, Stefano Francione, Anna Gersamia, Antonio Gil-Nagel, Alla Guekht, Sue Harrison, Hrvoje Hecimovic, Einar HeminghytEdouard Hirsch, Alena Javurkova, Reetta Kälviäinen, Nicole Kavan, Anna Kelemen, Vasilios K. Kimiskidis, Margarita Kirschner, Catherine Kleitz, Teia Kobulashvili, Mary H. Kosmidis, Selin Yagci Kurtish, Mathieu Lesourd, Sofia Ljunggren, Morten Ingvar Lossius, Kristina Malmgren, Ruta Mameniskiené, Patricia Martin-Sanfilippo, Petr Marusic, Marijke Miatton, Çiğdem Özkara, Federica Pelle, Guido Rubboli, Sarah Rudebeck, Philippe Ryvlin, Monique van Schooneveld, Elisabeth Schmid, Pia Magdalena Schmidt, Margitta Seeck, Bernhard J. Steinhoff, Sara Shavel-Jessop, Oana Tarta-Arsene, Eugen Trinka, Gerd Viggedal, Anne-Sophie Wendling, Juri-Alexander Witt, Christoph Helmstaedter, the E-PILEPSY consortium

^*Corresponding author for this work

Department of Clinical Medicine

41 Citations (Scopus)

Abstract

We explored the current practice with respect to the neuropsychological assessment of surgical epilepsy patients in European epilepsy centers, with the aim of harmonizing and establishing common standards. Twenty-six epilepsy centers and members of “E-PILEPSY” (a European pilot network of reference centers in refractory epilepsy and epilepsy surgery), were asked to report the status of neuropsychological assessment in adults and children via two different surveys. There was a consensus among these centers regarding the role of neuropsychology in the presurgical workup. Strong agreement was found on indications (localization, epileptic dysfunctions, adverse drugs effects, and postoperative monitoring) and the domains to be evaluated (memory, attention, executive functions, language, visuospatial skills, intelligence, depression, anxiety, and quality of life). Although 186 different tests are in use throughout these European centers, a core group of tests reflecting a moderate level of agreement could be discerned. Variability exists with regard to indications, protocols, and paradigms for the assessment of hemispheric language dominance. For the tests in use, little published evidence of clinical validity in epilepsy was provided. Participants in the survey reported a need for improvement concerning the validity of the tests, tools for the assessment of everyday functioning and accelerated forgetting, national norms, and test co-normalization. Based on the present survey, we documented a consensus regarding the indications and principles of neuropsychological testing. Despite the variety of tests in use, the survey indicated that there may be a core set of tests chosen based on experience, as well as on published evidence. By combining these findings with the results of an ongoing systematic literature review, we aim for a battery that can be recommended for the use across epilepsy surgical centers in Europe.

Original language	English
Journal	Epilepsia
Volume	58
Issue number	3
Pages (from-to)	343-355
Number of pages	13
ISSN	0013-9580
DOIs	https://doi.org/10.1111/epi.13646
Publication status	Published - Mar 2017

Keywords

Consensus
Diagnostic
Epilepsy surgery
Europe
Neuropsychology

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Vogt, V. L., Äikiä, M., del Barrio, A., Boon, P., Borbély, C., Bran, E., Braun, K., Carette, E., Clark, M., Cross, J. H., Dimova, P., Fabo, D., Foroglou, N., Francione, S., Gersamia, A., Gil-Nagel, A., Guekht, A., Harrison, S., Hecimovic, H., ... the E-PILEPSY consortium (2017). Current standards of neuropsychological assessment in epilepsy surgery centers across Europe. Epilepsia, 58(3), 343-355. https://doi.org/10.1111/epi.13646

Vogt, VL, Äikiä, M, del Barrio, A, Boon, P, Borbély, C, Bran, E, Braun, K, Carette, E, Clark, M, Cross, JH, Dimova, P, Fabo, D, Foroglou, N, Francione, S, Gersamia, A, Gil-Nagel, A, Guekht, A, Harrison, S, Hecimovic, H, Heminghyt, E, Hirsch, E, Javurkova, A, Kälviäinen, R, Kavan, N, Kelemen, A, Kimiskidis, VK, Kirschner, M, Kleitz, C, Kobulashvili, T, Kosmidis, MH, Kurtish, SY, Lesourd, M, Ljunggren, S, Lossius, MI, Malmgren, K, Mameniskiené, R, Martin-Sanfilippo, P, Marusic, P, Miatton, M, Özkara, Ç, Pelle, F, Rubboli, G, Rudebeck, S, Ryvlin, P, van Schooneveld, M, Schmid, E, Schmidt, PM, Seeck, M, Steinhoff, BJ, Shavel-Jessop, S, Tarta-Arsene, O, Trinka, E, Viggedal, G, Wendling, A-S, Witt, J-A, Helmstaedter, C & the E-PILEPSY consortium 2017, 'Current standards of neuropsychological assessment in epilepsy surgery centers across Europe', Epilepsia, vol. 58, no. 3, pp. 343-355. https://doi.org/10.1111/epi.13646

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title = "Current standards of neuropsychological assessment in epilepsy surgery centers across Europe",

abstract = "We explored the current practice with respect to the neuropsychological assessment of surgical epilepsy patients in European epilepsy centers, with the aim of harmonizing and establishing common standards. Twenty-six epilepsy centers and members of “E-PILEPSY” (a European pilot network of reference centers in refractory epilepsy and epilepsy surgery), were asked to report the status of neuropsychological assessment in adults and children via two different surveys. There was a consensus among these centers regarding the role of neuropsychology in the presurgical workup. Strong agreement was found on indications (localization, epileptic dysfunctions, adverse drugs effects, and postoperative monitoring) and the domains to be evaluated (memory, attention, executive functions, language, visuospatial skills, intelligence, depression, anxiety, and quality of life). Although 186 different tests are in use throughout these European centers, a core group of tests reflecting a moderate level of agreement could be discerned. Variability exists with regard to indications, protocols, and paradigms for the assessment of hemispheric language dominance. For the tests in use, little published evidence of clinical validity in epilepsy was provided. Participants in the survey reported a need for improvement concerning the validity of the tests, tools for the assessment of everyday functioning and accelerated forgetting, national norms, and test co-normalization. Based on the present survey, we documented a consensus regarding the indications and principles of neuropsychological testing. Despite the variety of tests in use, the survey indicated that there may be a core set of tests chosen based on experience, as well as on published evidence. By combining these findings with the results of an ongoing systematic literature review, we aim for a battery that can be recommended for the use across epilepsy surgical centers in Europe.",

keywords = "Consensus, Diagnostic, Epilepsy surgery, Europe, Neuropsychology",

author = "Vogt, {Viola Lara} and Marja {\"A}iki{\"a} and {del Barrio}, Antonio and Paul Boon and Csaba Borb{\'e}ly and Ema Bran and Kees Braun and Evelien Carette and Maria Clark and Cross, {Judith Helen} and Petia Dimova and Daniel Fabo and Nikolaos Foroglou and Stefano Francione and Anna Gersamia and Antonio Gil-Nagel and Alla Guekht and Sue Harrison and Hrvoje Hecimovic and Einar Heminghyt and Edouard Hirsch and Alena Javurkova and Reetta K{\"a}lvi{\"a}inen and Nicole Kavan and Anna Kelemen and Kimiskidis, {Vasilios K.} and Margarita Kirschner and Catherine Kleitz and Teia Kobulashvili and Kosmidis, {Mary H.} and Kurtish, {Selin Yagci} and Mathieu Lesourd and Sofia Ljunggren and Lossius, {Morten Ingvar} and Kristina Malmgren and Ruta Mameniskien{\'e} and Patricia Martin-Sanfilippo and Petr Marusic and Marijke Miatton and {\c C}iğdem {\"O}zkara and Federica Pelle and Guido Rubboli and Sarah Rudebeck and Philippe Ryvlin and {van Schooneveld}, Monique and Elisabeth Schmid and Schmidt, {Pia Magdalena} and Margitta Seeck and Steinhoff, {Bernhard J.} and Sara Shavel-Jessop and Oana Tarta-Arsene and Eugen Trinka and Gerd Viggedal and Anne-Sophie Wendling and Juri-Alexander Witt and Christoph Helmstaedter and {the E-PILEPSY consortium}",

year = "2017",

month = mar,

doi = "10.1111/epi.13646",

language = "English",

volume = "58",

pages = "343--355",

journal = "Epilepsia",

issn = "0013-9580",

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number = "3",

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T1 - Current standards of neuropsychological assessment in epilepsy surgery centers across Europe

AU - Vogt, Viola Lara

AU - Äikiä, Marja

AU - del Barrio, Antonio

AU - Boon, Paul

AU - Borbély, Csaba

AU - Bran, Ema

AU - Braun, Kees

AU - Carette, Evelien

AU - Clark, Maria

AU - Cross, Judith Helen

AU - Dimova, Petia

AU - Fabo, Daniel

AU - Foroglou, Nikolaos

AU - Francione, Stefano

AU - Gersamia, Anna

AU - Gil-Nagel, Antonio

AU - Guekht, Alla

AU - Harrison, Sue

AU - Hecimovic, Hrvoje

AU - Heminghyt, Einar

AU - Hirsch, Edouard

AU - Javurkova, Alena

AU - Kälviäinen, Reetta

AU - Kavan, Nicole

AU - Kelemen, Anna

AU - Kimiskidis, Vasilios K.

AU - Kirschner, Margarita

AU - Kleitz, Catherine

AU - Kobulashvili, Teia

AU - Kosmidis, Mary H.

AU - Kurtish, Selin Yagci

AU - Lesourd, Mathieu

AU - Ljunggren, Sofia

AU - Lossius, Morten Ingvar

AU - Malmgren, Kristina

AU - Mameniskiené, Ruta

AU - Martin-Sanfilippo, Patricia

AU - Marusic, Petr

AU - Miatton, Marijke

AU - Özkara, Çiğdem

AU - Pelle, Federica

AU - Rubboli, Guido

AU - Rudebeck, Sarah

AU - Ryvlin, Philippe

AU - van Schooneveld, Monique

AU - Schmid, Elisabeth

AU - Schmidt, Pia Magdalena

AU - Seeck, Margitta

AU - Steinhoff, Bernhard J.

AU - Shavel-Jessop, Sara

AU - Tarta-Arsene, Oana

AU - Trinka, Eugen

AU - Viggedal, Gerd

AU - Wendling, Anne-Sophie

AU - Witt, Juri-Alexander

AU - Helmstaedter, Christoph

AU - the E-PILEPSY consortium

PY - 2017/3

Y1 - 2017/3

N2 - We explored the current practice with respect to the neuropsychological assessment of surgical epilepsy patients in European epilepsy centers, with the aim of harmonizing and establishing common standards. Twenty-six epilepsy centers and members of “E-PILEPSY” (a European pilot network of reference centers in refractory epilepsy and epilepsy surgery), were asked to report the status of neuropsychological assessment in adults and children via two different surveys. There was a consensus among these centers regarding the role of neuropsychology in the presurgical workup. Strong agreement was found on indications (localization, epileptic dysfunctions, adverse drugs effects, and postoperative monitoring) and the domains to be evaluated (memory, attention, executive functions, language, visuospatial skills, intelligence, depression, anxiety, and quality of life). Although 186 different tests are in use throughout these European centers, a core group of tests reflecting a moderate level of agreement could be discerned. Variability exists with regard to indications, protocols, and paradigms for the assessment of hemispheric language dominance. For the tests in use, little published evidence of clinical validity in epilepsy was provided. Participants in the survey reported a need for improvement concerning the validity of the tests, tools for the assessment of everyday functioning and accelerated forgetting, national norms, and test co-normalization. Based on the present survey, we documented a consensus regarding the indications and principles of neuropsychological testing. Despite the variety of tests in use, the survey indicated that there may be a core set of tests chosen based on experience, as well as on published evidence. By combining these findings with the results of an ongoing systematic literature review, we aim for a battery that can be recommended for the use across epilepsy surgical centers in Europe.

AB - We explored the current practice with respect to the neuropsychological assessment of surgical epilepsy patients in European epilepsy centers, with the aim of harmonizing and establishing common standards. Twenty-six epilepsy centers and members of “E-PILEPSY” (a European pilot network of reference centers in refractory epilepsy and epilepsy surgery), were asked to report the status of neuropsychological assessment in adults and children via two different surveys. There was a consensus among these centers regarding the role of neuropsychology in the presurgical workup. Strong agreement was found on indications (localization, epileptic dysfunctions, adverse drugs effects, and postoperative monitoring) and the domains to be evaluated (memory, attention, executive functions, language, visuospatial skills, intelligence, depression, anxiety, and quality of life). Although 186 different tests are in use throughout these European centers, a core group of tests reflecting a moderate level of agreement could be discerned. Variability exists with regard to indications, protocols, and paradigms for the assessment of hemispheric language dominance. For the tests in use, little published evidence of clinical validity in epilepsy was provided. Participants in the survey reported a need for improvement concerning the validity of the tests, tools for the assessment of everyday functioning and accelerated forgetting, national norms, and test co-normalization. Based on the present survey, we documented a consensus regarding the indications and principles of neuropsychological testing. Despite the variety of tests in use, the survey indicated that there may be a core set of tests chosen based on experience, as well as on published evidence. By combining these findings with the results of an ongoing systematic literature review, we aim for a battery that can be recommended for the use across epilepsy surgical centers in Europe.

KW - Consensus

KW - Diagnostic

KW - Epilepsy surgery

KW - Europe

KW - Neuropsychology

U2 - 10.1111/epi.13646

DO - 10.1111/epi.13646

M3 - Journal article

C2 - 28067423

AN - SCOPUS:85008439776

SN - 0013-9580

VL - 58

SP - 343

EP - 355

JO - Epilepsia

JF - Epilepsia

IS - 3

ER -

Current standards of neuropsychological assessment in epilepsy surgery centers across Europe

Abstract

Keywords

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