Curcuminoids from Curcuma longa and their inhibitory activities on influenza A neuraminidases

Trong Tuan Dao; Ho Keun Won; Eun Hee Kim; Junsoo Park; Boo Yeon Won; Won Keun Oh

Curcuminoids from Curcuma longa and their inhibitory activities on influenza A neuraminidases

Trong Tuan Dao, Ho Keun Won, Eun Hee Kim, Junsoo Park, Boo Yeon Won, Won Keun Oh

58 Citations (Scopus)

Abstract

The emergence of drug-resistant influenza viruses and the threat of pandemics highlight the need for new and effective antiviral agents. In this study, we describe the isolation of 3 new (1–3) and 10 known (4−13) curcuminoids from a methanol extract of Curcuma longa L. All compounds had strong inhibitory effects on the neuraminidases from two influenza viral strains, H1N1 and H9N2, as noncompetitive inhibitors with IC50 values ranging from 6.18 ± 0.64 to 40.17 ± 0.79 μg/ml and 3.77 ± 0.75 to 31.82 ± 1.33 μg/ml, respectively. Compounds 4, 5, and 13 also exhibited significant inhibitory activity against the neuraminidases from novel influenza H1N1 (WT) and oseltamivir-resistant novel H1N1 (H274Y mutant) expressed in 293T cells. Our results suggest that the curcuminoids from C. longa may be potential supplemental molecules in the prevention and treatment of disease by influenza viruses.

Original language	English
Journal	Food Chemistry
Volume	Volume 134
Issue number	Issue 1
Pages (from-to)	21–28
ISSN	0308-8146
Publication status	Published - Sept 2012

Cite this

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title = "Curcuminoids from Curcuma longa and their inhibitory activities on influenza A neuraminidases",

abstract = "The emergence of drug-resistant influenza viruses and the threat of pandemics highlight the need for new and effective antiviral agents. In this study, we describe the isolation of 3 new (1–3) and 10 known (4−13) curcuminoids from a methanol extract of Curcuma longa L. All compounds had strong inhibitory effects on the neuraminidases from two influenza viral strains, H1N1 and H9N2, as noncompetitive inhibitors with IC50 values ranging from 6.18 ± 0.64 to 40.17 ± 0.79 μg/ml and 3.77 ± 0.75 to 31.82 ± 1.33 μg/ml, respectively. Compounds 4, 5, and 13 also exhibited significant inhibitory activity against the neuraminidases from novel influenza H1N1 (WT) and oseltamivir-resistant novel H1N1 (H274Y mutant) expressed in 293T cells. Our results suggest that the curcuminoids from C. longa may be potential supplemental molecules in the prevention and treatment of disease by influenza viruses.",

author = "Dao, {Trong Tuan} and Won, {Ho Keun} and Kim, {Eun Hee} and Junsoo Park and Won, {Boo Yeon} and Oh, {Won Keun}",

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journal = "Food Chemistry",

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TY - JOUR

T1 - Curcuminoids from Curcuma longa and their inhibitory activities on influenza A neuraminidases

AU - Dao, Trong Tuan

AU - Won, Ho Keun

AU - Kim, Eun Hee

AU - Park, Junsoo

AU - Won, Boo Yeon

AU - Oh, Won Keun

PY - 2012/9

Y1 - 2012/9

N2 - The emergence of drug-resistant influenza viruses and the threat of pandemics highlight the need for new and effective antiviral agents. In this study, we describe the isolation of 3 new (1–3) and 10 known (4−13) curcuminoids from a methanol extract of Curcuma longa L. All compounds had strong inhibitory effects on the neuraminidases from two influenza viral strains, H1N1 and H9N2, as noncompetitive inhibitors with IC50 values ranging from 6.18 ± 0.64 to 40.17 ± 0.79 μg/ml and 3.77 ± 0.75 to 31.82 ± 1.33 μg/ml, respectively. Compounds 4, 5, and 13 also exhibited significant inhibitory activity against the neuraminidases from novel influenza H1N1 (WT) and oseltamivir-resistant novel H1N1 (H274Y mutant) expressed in 293T cells. Our results suggest that the curcuminoids from C. longa may be potential supplemental molecules in the prevention and treatment of disease by influenza viruses.

AB - The emergence of drug-resistant influenza viruses and the threat of pandemics highlight the need for new and effective antiviral agents. In this study, we describe the isolation of 3 new (1–3) and 10 known (4−13) curcuminoids from a methanol extract of Curcuma longa L. All compounds had strong inhibitory effects on the neuraminidases from two influenza viral strains, H1N1 and H9N2, as noncompetitive inhibitors with IC50 values ranging from 6.18 ± 0.64 to 40.17 ± 0.79 μg/ml and 3.77 ± 0.75 to 31.82 ± 1.33 μg/ml, respectively. Compounds 4, 5, and 13 also exhibited significant inhibitory activity against the neuraminidases from novel influenza H1N1 (WT) and oseltamivir-resistant novel H1N1 (H274Y mutant) expressed in 293T cells. Our results suggest that the curcuminoids from C. longa may be potential supplemental molecules in the prevention and treatment of disease by influenza viruses.

M3 - Journal article

SN - 0308-8146

VL - Volume 134

SP - 21

EP - 28

JO - Food Chemistry

JF - Food Chemistry

IS - Issue 1

ER -

Curcuminoids from Curcuma longa and their inhibitory activities on influenza A neuraminidases

Abstract

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