Cryopreservation and autotransplantation of human ovarian tissue prior to cytotoxic therapy--a technique in its infancy but already successful in fertility preservation

Michael von Wolff; Jacques Donnez; Outi Hovatta; Victoria Keros; Theodoris Maltaris; Markus Montag; Bruno Salle; Murat Sonmezer; Claus Yding Andersen

doi:10.1016/j.ejca.2009.01.029

Cryopreservation and autotransplantation of human ovarian tissue prior to cytotoxic therapy--a technique in its infancy but already successful in fertility preservation

Michael von Wolff, Jacques Donnez, Outi Hovatta, Victoria Keros, Theodoris Maltaris, Markus Montag, Bruno Salle, Murat Sonmezer, Claus Yding Andersen

169 Citations (Scopus)

Abstract

Increasing survival rates in young cancer patients, new reproductive techniques and the growing interest in quality of life after gonadotoxic cancer therapies have placed fertility preservation as an important issue to oncologists, fertility specialists and patients. Several techniques are now available for fertility preservation in these patients. A new promising method is cryopreservation and transplantation of ovarian cortex. Ovarian tissue can be extracted by laparoscopy without any significant delay of gonadotoxic therapy. The tissue can be cryopreserved by specialised centres of reproductive medicine and transplanted in case the women experience premature ovarian failure (POF). This review summarises the European expertise on cryopreservation and transplantation of ovarian tissue, following around 30 reported transplantations globally, resulting in six live births and several ongoing pregnancies. It emphasises that fertility preservation by the cryopreservation of ovarian tissue is a new but already a successful clinical option, which can be considered for selected cancer patients.

Original language	English
Journal	European Journal of Cancer
Volume	45
Issue number	9
Pages (from-to)	1547-53
Number of pages	6
ISSN	0959-8049
DOIs	https://doi.org/10.1016/j.ejca.2009.01.029
Publication status	Published - 2009

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von Wolff, M., Donnez, J., Hovatta, O., Keros, V., Maltaris, T., Montag, M., Salle, B., Sonmezer, M., & Andersen, C. Y. (2009). Cryopreservation and autotransplantation of human ovarian tissue prior to cytotoxic therapy--a technique in its infancy but already successful in fertility preservation. European Journal of Cancer, 45(9), 1547-53. https://doi.org/10.1016/j.ejca.2009.01.029

Cryopreservation and autotransplantation of human ovarian tissue prior to cytotoxic therapy--a technique in its infancy but already successful in fertility preservation. / von Wolff, Michael; Donnez, Jacques; Hovatta, Outi et al.

In: European Journal of Cancer, Vol. 45, No. 9, 2009, p. 1547-53.

Research output: Contribution to journal › Journal article › Research › peer-review

von Wolff, M, Donnez, J, Hovatta, O, Keros, V, Maltaris, T, Montag, M, Salle, B, Sonmezer, M & Andersen, CY 2009, 'Cryopreservation and autotransplantation of human ovarian tissue prior to cytotoxic therapy--a technique in its infancy but already successful in fertility preservation', European Journal of Cancer, vol. 45, no. 9, pp. 1547-53. https://doi.org/10.1016/j.ejca.2009.01.029

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title = "Cryopreservation and autotransplantation of human ovarian tissue prior to cytotoxic therapy--a technique in its infancy but already successful in fertility preservation",

abstract = "Increasing survival rates in young cancer patients, new reproductive techniques and the growing interest in quality of life after gonadotoxic cancer therapies have placed fertility preservation as an important issue to oncologists, fertility specialists and patients. Several techniques are now available for fertility preservation in these patients. A new promising method is cryopreservation and transplantation of ovarian cortex. Ovarian tissue can be extracted by laparoscopy without any significant delay of gonadotoxic therapy. The tissue can be cryopreserved by specialised centres of reproductive medicine and transplanted in case the women experience premature ovarian failure (POF). This review summarises the European expertise on cryopreservation and transplantation of ovarian tissue, following around 30 reported transplantations globally, resulting in six live births and several ongoing pregnancies. It emphasises that fertility preservation by the cryopreservation of ovarian tissue is a new but already a successful clinical option, which can be considered for selected cancer patients.",

author = "{von Wolff}, Michael and Jacques Donnez and Outi Hovatta and Victoria Keros and Theodoris Maltaris and Markus Montag and Bruno Salle and Murat Sonmezer and Andersen, {Claus Yding}",

note = "Keywords: Adult; Antineoplastic Agents; Cryopreservation; Female; Fertility; Humans; Ovarian Failure, Premature; Ovarian Neoplasms; Ovary; Tissue Banks",

year = "2009",

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AU - von Wolff, Michael

AU - Donnez, Jacques

AU - Hovatta, Outi

AU - Keros, Victoria

AU - Maltaris, Theodoris

AU - Montag, Markus

AU - Salle, Bruno

AU - Sonmezer, Murat

AU - Andersen, Claus Yding

N1 - Keywords: Adult; Antineoplastic Agents; Cryopreservation; Female; Fertility; Humans; Ovarian Failure, Premature; Ovarian Neoplasms; Ovary; Tissue Banks

PY - 2009

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N2 - Increasing survival rates in young cancer patients, new reproductive techniques and the growing interest in quality of life after gonadotoxic cancer therapies have placed fertility preservation as an important issue to oncologists, fertility specialists and patients. Several techniques are now available for fertility preservation in these patients. A new promising method is cryopreservation and transplantation of ovarian cortex. Ovarian tissue can be extracted by laparoscopy without any significant delay of gonadotoxic therapy. The tissue can be cryopreserved by specialised centres of reproductive medicine and transplanted in case the women experience premature ovarian failure (POF). This review summarises the European expertise on cryopreservation and transplantation of ovarian tissue, following around 30 reported transplantations globally, resulting in six live births and several ongoing pregnancies. It emphasises that fertility preservation by the cryopreservation of ovarian tissue is a new but already a successful clinical option, which can be considered for selected cancer patients.

AB - Increasing survival rates in young cancer patients, new reproductive techniques and the growing interest in quality of life after gonadotoxic cancer therapies have placed fertility preservation as an important issue to oncologists, fertility specialists and patients. Several techniques are now available for fertility preservation in these patients. A new promising method is cryopreservation and transplantation of ovarian cortex. Ovarian tissue can be extracted by laparoscopy without any significant delay of gonadotoxic therapy. The tissue can be cryopreserved by specialised centres of reproductive medicine and transplanted in case the women experience premature ovarian failure (POF). This review summarises the European expertise on cryopreservation and transplantation of ovarian tissue, following around 30 reported transplantations globally, resulting in six live births and several ongoing pregnancies. It emphasises that fertility preservation by the cryopreservation of ovarian tissue is a new but already a successful clinical option, which can be considered for selected cancer patients.

U2 - 10.1016/j.ejca.2009.01.029

DO - 10.1016/j.ejca.2009.01.029

M3 - Journal article

C2 - 19264478

SN - 0959-8049

VL - 45

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JO - European Journal of Cancer, Supplement

JF - European Journal of Cancer, Supplement

IS - 9

ER -

Cryopreservation and autotransplantation of human ovarian tissue prior to cytotoxic therapy--a technique in its infancy but already successful in fertility preservation

Abstract

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