CRP and suPAR are differently related to anthropometry and subclinical organ damage

Stig Lyngbæk; Thomas Sehestedt; Jacob L Marott; Tine W Hansen; Michael H Olsen; Ove Andersen; Allan Linneberg; Sten Madsbad; Steen B Haugaard; Jesper Eugen-Olsen; Jørgen Jeppesen

doi:10.1016/j.ijcard.2012.03.040

CRP and suPAR are differently related to anthropometry and subclinical organ damage

Stig Lyngbæk, Thomas Sehestedt, Jacob L Marott, Tine W Hansen, Michael H Olsen, Ove Andersen, Allan Linneberg, Sten Madsbad, Steen B Haugaard, Jesper Eugen-Olsen, Jørgen Jeppesen

Medicinsk Sociologi

68 Citations (Scopus)

Abstract

BACKGROUND: Low-grade inflammation is a marker for cardiovascular disease (CVD). The inflammatory biomarkers C-reactive protein (CRP) and soluble urokinase plasminogen activator receptor (suPAR) independently predict CVD. We tested the hypothesis that these biomarkers reflect different aspects of the inflammation associated with CVD. METHODS: We studied 2273 subjects without CVD. Log-transformed CRP and suPAR were included in general linear and logistic regression models to compare associations with measures of anthropometry and subclinical organ damage (SOD). Owing to interactions on body mass index (BMI) (P3: 1.31 (1.16-1.47), whereas log-CRP was not (1.00 (0.89-1.11))). CONCLUSIONS: CRP is positively associated with anthropometric measures, whereas suPAR is linked to endothelial dysfunction and atherosclerosis.

Original language	English
Journal	International Journal of Cardiology
Volume	167
Issue number	3
Pages (from-to)	781-5
Number of pages	5
ISSN	0167-5273
DOIs	https://doi.org/10.1016/j.ijcard.2012.03.040
Publication status	Published - 10 Aug 2013

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title = "CRP and suPAR are differently related to anthropometry and subclinical organ damage",

abstract = "BACKGROUND: Low-grade inflammation is a marker for cardiovascular disease (CVD). The inflammatory biomarkers C-reactive protein (CRP) and soluble urokinase plasminogen activator receptor (suPAR) independently predict CVD. We tested the hypothesis that these biomarkers reflect different aspects of the inflammation associated with CVD. METHODS: We studied 2273 subjects without CVD. Log-transformed CRP and suPAR were included in general linear and logistic regression models to compare associations with measures of anthropometry and subclinical organ damage (SOD). Owing to interactions on body mass index (BMI) (P3: 1.31 (1.16-1.47), whereas log-CRP was not (1.00 (0.89-1.11))). CONCLUSIONS: CRP is positively associated with anthropometric measures, whereas suPAR is linked to endothelial dysfunction and atherosclerosis.",

author = "Stig Lyngb{\ae}k and Thomas Sehestedt and Marott, {Jacob L} and Hansen, {Tine W} and Olsen, {Michael H} and Ove Andersen and Allan Linneberg and Sten Madsbad and Haugaard, {Steen B} and Jesper Eugen-Olsen and J{\o}rgen Jeppesen",

year = "2013",

month = aug,

day = "10",

doi = "10.1016/j.ijcard.2012.03.040",

language = "English",

volume = "167",

pages = "781--5",

journal = "International Journal of Cardiology",

issn = "0167-5273",

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TY - JOUR

T1 - CRP and suPAR are differently related to anthropometry and subclinical organ damage

AU - Lyngbæk, Stig

AU - Sehestedt, Thomas

AU - Marott, Jacob L

AU - Hansen, Tine W

AU - Olsen, Michael H

AU - Andersen, Ove

AU - Linneberg, Allan

AU - Madsbad, Sten

AU - Haugaard, Steen B

AU - Eugen-Olsen, Jesper

AU - Jeppesen, Jørgen

PY - 2013/8/10

Y1 - 2013/8/10

N2 - BACKGROUND: Low-grade inflammation is a marker for cardiovascular disease (CVD). The inflammatory biomarkers C-reactive protein (CRP) and soluble urokinase plasminogen activator receptor (suPAR) independently predict CVD. We tested the hypothesis that these biomarkers reflect different aspects of the inflammation associated with CVD. METHODS: We studied 2273 subjects without CVD. Log-transformed CRP and suPAR were included in general linear and logistic regression models to compare associations with measures of anthropometry and subclinical organ damage (SOD). Owing to interactions on body mass index (BMI) (P3: 1.31 (1.16-1.47), whereas log-CRP was not (1.00 (0.89-1.11))). CONCLUSIONS: CRP is positively associated with anthropometric measures, whereas suPAR is linked to endothelial dysfunction and atherosclerosis.

AB - BACKGROUND: Low-grade inflammation is a marker for cardiovascular disease (CVD). The inflammatory biomarkers C-reactive protein (CRP) and soluble urokinase plasminogen activator receptor (suPAR) independently predict CVD. We tested the hypothesis that these biomarkers reflect different aspects of the inflammation associated with CVD. METHODS: We studied 2273 subjects without CVD. Log-transformed CRP and suPAR were included in general linear and logistic regression models to compare associations with measures of anthropometry and subclinical organ damage (SOD). Owing to interactions on body mass index (BMI) (P3: 1.31 (1.16-1.47), whereas log-CRP was not (1.00 (0.89-1.11))). CONCLUSIONS: CRP is positively associated with anthropometric measures, whereas suPAR is linked to endothelial dysfunction and atherosclerosis.

U2 - 10.1016/j.ijcard.2012.03.040

DO - 10.1016/j.ijcard.2012.03.040

M3 - Journal article

C2 - 22459389

SN - 0167-5273

VL - 167

SP - 781

EP - 785

JO - International Journal of Cardiology

JF - International Journal of Cardiology

IS - 3

ER -

CRP and suPAR are differently related to anthropometry and subclinical organ damage

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