Course of illness in a sample of 265 patients with first-episode psychosis--five-year follow-up of the Danish OPUS trial

Mette Bertelsen; Pia Jeppesen; Lone Petersen; Anne Thorup; Johan Øhlenschlaeger; Phuong Le Quach; Torben Østergaard Christensen; Gertrud Krarup; Per Jørgensen; Merete Nordentoft

doi:10.1016/j.schres.2008.09.018

Course of illness in a sample of 265 patients with first-episode psychosis--five-year follow-up of the Danish OPUS trial

Mette Bertelsen, Pia Jeppesen, Lone Petersen, Anne Thorup, Johan Øhlenschlaeger, Phuong Le Quach, Torben Østergaard Christensen, Gertrud Krarup, Per Jørgensen, Merete Nordentoft

76 Citations (Scopus)

Abstract

There is an ongoing debate as to whether psychosis is a progressively deteriorating illness or one of progressive amelioration. This paper aims at investigating the rate of recovery and institutionalization and predicting a continuous illness course in a descriptive prospective study of a sub-sample of the OPUS trial of 265 first-episode psychotic patients after five years. Recovery, defined as no psychotic or negative symptoms, living independently, GAF (f)>59, working or studying, was reached for 18% after five years, whereas 13% were institutionalized either at hospital or supported housing after five years. Male gender (OR 1.9, 95% CI 1.06 to 3.23), premorbid social functioning (OR 1.2, 95% CI 1.01 to 1.33), psychotic symptoms (OR 1.3, 95% CI 1.07 to 1.66), and negative symptoms (OR 1.3, 95% CI 1.01 to 1.67) were found to predict a continuous illness course at five-year follow-up. Rates of recovery and institutionalization contradict the assumption that the illness deteriorates progressively, since no changes in the rates are seen from two to five years.

Original language	English
Journal	Schizophrenia Research
Volume	107
Issue number	2-3
Pages (from-to)	173-8
Number of pages	5
ISSN	0920-9964
DOIs	https://doi.org/10.1016/j.schres.2008.09.018
Publication status	Published - 2009

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Bertelsen, M., Jeppesen, P., Petersen, L., Thorup, A., Øhlenschlaeger, J., Le Quach, P., Østergaard Christensen, T., Krarup, G., Jørgensen, P., & Nordentoft, M. (2009). Course of illness in a sample of 265 patients with first-episode psychosis--five-year follow-up of the Danish OPUS trial. Schizophrenia Research, 107(2-3), 173-8. https://doi.org/10.1016/j.schres.2008.09.018

Bertelsen, M, Jeppesen, P, Petersen, L, Thorup, A, Øhlenschlaeger, J, Le Quach, P, Østergaard Christensen, T, Krarup, G, Jørgensen, P & Nordentoft, M 2009, 'Course of illness in a sample of 265 patients with first-episode psychosis--five-year follow-up of the Danish OPUS trial', Schizophrenia Research, vol. 107, no. 2-3, pp. 173-8. https://doi.org/10.1016/j.schres.2008.09.018

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title = "Course of illness in a sample of 265 patients with first-episode psychosis--five-year follow-up of the Danish OPUS trial",

abstract = "There is an ongoing debate as to whether psychosis is a progressively deteriorating illness or one of progressive amelioration. This paper aims at investigating the rate of recovery and institutionalization and predicting a continuous illness course in a descriptive prospective study of a sub-sample of the OPUS trial of 265 first-episode psychotic patients after five years. Recovery, defined as no psychotic or negative symptoms, living independently, GAF (f)>59, working or studying, was reached for 18% after five years, whereas 13% were institutionalized either at hospital or supported housing after five years. Male gender (OR 1.9, 95% CI 1.06 to 3.23), premorbid social functioning (OR 1.2, 95% CI 1.01 to 1.33), psychotic symptoms (OR 1.3, 95% CI 1.07 to 1.66), and negative symptoms (OR 1.3, 95% CI 1.01 to 1.67) were found to predict a continuous illness course at five-year follow-up. Rates of recovery and institutionalization contradict the assumption that the illness deteriorates progressively, since no changes in the rates are seen from two to five years.",

author = "Mette Bertelsen and Pia Jeppesen and Lone Petersen and Anne Thorup and Johan {\O}hlenschlaeger and {Le Quach}, Phuong and {{\O}stergaard Christensen}, Torben and Gertrud Krarup and Per J{\o}rgensen and Merete Nordentoft",

note = "Keywords: Adult; Case Management; Combined Modality Therapy; Community Mental Health Services; Comorbidity; Denmark; Family Therapy; Female; Humans; Longitudinal Studies; Male; Patient Readmission; Psychiatric Status Rating Scales; Psychotic Disorders; Schizophrenia; Schizophrenic Psychology; Socialization; Substance-Related Disorders; Young Adult",

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AU - Bertelsen, Mette

AU - Jeppesen, Pia

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AU - Thorup, Anne

AU - Øhlenschlaeger, Johan

AU - Le Quach, Phuong

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AU - Krarup, Gertrud

AU - Jørgensen, Per

AU - Nordentoft, Merete

N1 - Keywords: Adult; Case Management; Combined Modality Therapy; Community Mental Health Services; Comorbidity; Denmark; Family Therapy; Female; Humans; Longitudinal Studies; Male; Patient Readmission; Psychiatric Status Rating Scales; Psychotic Disorders; Schizophrenia; Schizophrenic Psychology; Socialization; Substance-Related Disorders; Young Adult

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N2 - There is an ongoing debate as to whether psychosis is a progressively deteriorating illness or one of progressive amelioration. This paper aims at investigating the rate of recovery and institutionalization and predicting a continuous illness course in a descriptive prospective study of a sub-sample of the OPUS trial of 265 first-episode psychotic patients after five years. Recovery, defined as no psychotic or negative symptoms, living independently, GAF (f)>59, working or studying, was reached for 18% after five years, whereas 13% were institutionalized either at hospital or supported housing after five years. Male gender (OR 1.9, 95% CI 1.06 to 3.23), premorbid social functioning (OR 1.2, 95% CI 1.01 to 1.33), psychotic symptoms (OR 1.3, 95% CI 1.07 to 1.66), and negative symptoms (OR 1.3, 95% CI 1.01 to 1.67) were found to predict a continuous illness course at five-year follow-up. Rates of recovery and institutionalization contradict the assumption that the illness deteriorates progressively, since no changes in the rates are seen from two to five years.

AB - There is an ongoing debate as to whether psychosis is a progressively deteriorating illness or one of progressive amelioration. This paper aims at investigating the rate of recovery and institutionalization and predicting a continuous illness course in a descriptive prospective study of a sub-sample of the OPUS trial of 265 first-episode psychotic patients after five years. Recovery, defined as no psychotic or negative symptoms, living independently, GAF (f)>59, working or studying, was reached for 18% after five years, whereas 13% were institutionalized either at hospital or supported housing after five years. Male gender (OR 1.9, 95% CI 1.06 to 3.23), premorbid social functioning (OR 1.2, 95% CI 1.01 to 1.33), psychotic symptoms (OR 1.3, 95% CI 1.07 to 1.66), and negative symptoms (OR 1.3, 95% CI 1.01 to 1.67) were found to predict a continuous illness course at five-year follow-up. Rates of recovery and institutionalization contradict the assumption that the illness deteriorates progressively, since no changes in the rates are seen from two to five years.

U2 - 10.1016/j.schres.2008.09.018

DO - 10.1016/j.schres.2008.09.018

M3 - Journal article

C2 - 18945593

SN - 0920-9964

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SP - 173

EP - 178

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 2-3

ER -

Course of illness in a sample of 265 patients with first-episode psychosis--five-year follow-up of the Danish OPUS trial

Abstract

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