Costs and Resource Utilization for Diagnosis and Treatment During the Initial Year in a European Inflammatory Bowel Disease Inception Cohort: An ECCO-EpiCom Study

J. Burisch; Hillel Vardi; Natalia Pedersen; Marko Brinar; Silvja Cukovic-Cavka; Ioannis Kaimakliotis; Dana Duricova; Martin Bortlik; Olga Shonová; Ida Vind; Søren Avnstrøm; Niels Thorsgaard; Susanne Krabbe; Vibeke Andersen; Jens F Dahlerup; Jens Kjeldsen; Riina Salupere; Jónger Olsen; Kári R Nielsen; Pia Manninen; Pekka Collin; Konstantinnos H Katsanos; Epameinondas V Tsianos; Karin Ladefoged; Laszlo Lakatos; Yvonne Bailey; Colm OʼMorain; Doron Schwartz; Guido Lupinacci; Angelo De Padova; Laimas Jonaitis; Limas Kupcinskas; Svetlana Turcan; Louisa Barros; Fernando Magro; Daniela Lazar; Adrian Goldis; Inna Nikulina; Elena Belousova; Alberto Fernandez; Juan R Pineda; Sven Almer; Jonas Halfvarson; Her-Hsin Tsai; Shaji Sebastian; Michael Friger; Dan Greenberg; Peter L Lakatos; Ebbe Langholz; Pia Munkholm; EpiCom Group

doi:10.1097/mib.0000000000000250

Costs and Resource Utilization for Diagnosis and Treatment During the Initial Year in a European Inflammatory Bowel Disease Inception Cohort: An ECCO-EpiCom Study

J. Burisch, Hillel Vardi, Natalia Pedersen, Marko Brinar, Silvja Cukovic-Cavka, Ioannis Kaimakliotis, Dana Duricova, Martin Bortlik, Olga Shonová, Ida Vind, Søren Avnstrøm, Niels Thorsgaard, Susanne Krabbe, Vibeke Andersen, Jens F Dahlerup, Jens Kjeldsen, Riina Salupere, Jónger Olsen, Kári R Nielsen, Pia ManninenPekka Collin, Konstantinnos H Katsanos, Epameinondas V Tsianos, Karin Ladefoged, Laszlo Lakatos, Yvonne Bailey, Colm OʼMorain, Doron Schwartz, Guido Lupinacci, Angelo De Padova, Laimas Jonaitis, Limas Kupcinskas, Svetlana Turcan, Louisa Barros, Fernando Magro, Daniela Lazar, Adrian Goldis, Inna Nikulina, Elena Belousova, Alberto Fernandez, Juan R Pineda, Sven Almer, Jonas Halfvarson, Her-Hsin Tsai, Shaji Sebastian, Michael Friger, Dan Greenberg, Peter L Lakatos, Ebbe Langholz, Pia Munkholm, EpiCom Group

Department of Clinical Medicine

39 Citations (Scopus)

Abstract

Background: No direct comparison of health care cost in patients with inflammatory bowel disease across the European continent exists. The aim of this study was to assess the costs of investigations and treatment for diagnostics and during the first year after diagnosis in Europe. Methods: The EpiCom cohort is a prospective population-based inception cohort of unselected inflammatory bowel disease patients from 31 Western and Eastern European centers. Patients were followed every third month from diagnosis, and clinical data regarding treatment and investigations were collected. Costs were calculated in euros (€) using the Danish Health Costs Register. Results: One thousand three hundred sixty-seven patients were followed, 710 with ulcerative colitis, 509 with Crohn's disease, and 148 with inflammatory bowel disease unclassified. Total expenditure for the cohort was €5,408,174 (investigations: €2,042,990 [38%], surgery: €1,427,648 [26%], biologicals: €781,089 [14%], and standard treatment: €1,156,520 [22%)]). Mean crude expenditure per patient in Western Europe (Eastern Europe) with Crohn's disease: investigations €1803 (€2160) (P = 0.44), surgery €11,489 (€13,973) (P = 0.14), standard treatment €1027 (€824) (P = 0.51), and biologicals €7376 (€8307) (P = 0.31). Mean crude expenditure per patient in Western Europe (Eastern Europe) with ulcerative colitis: investigations €1189 (€1518) (P < 0.01), surgery €18,414 (€12,395) (P = 0.18), standard treatment €896 (€798) (P < 0.05), and biologicals €5681 (€72) (P = 0.51). Conclusions: In this population-based unselected cohort, costs during the first year of disease were mainly incurred by investigative procedures and surgeries. However, biologicals accounted for >15% of costs. Long-term follow-up of the cohort is needed to assess the cost-effectiveness of biological agents.

Original language	English
Journal	Inflammatory Bowel Diseases
Volume	21
Issue number	1
Pages (from-to)	121-131
Number of pages	11
ISSN	1078-0998
DOIs	https://doi.org/10.1097/mib.0000000000000250
Publication status	Published - 1 Jan 2015

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Cohort Studies
Europe
Female
Follow-Up Studies
Health Care Costs
Health Resources
Humans
Inflammatory Bowel Diseases
Male
Middle Aged
Prognosis
Surveys and Questionnaires
Time Factors
Young Adult

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https://academic.oup.com/ibdjournal/article-pdf/21/1/121/23413265/ibd0121.pdf

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Burisch, J., Vardi, H., Pedersen, N., Brinar, M., Cukovic-Cavka, S., Kaimakliotis, I., Duricova, D., Bortlik, M., Shonová, O., Vind, I., Avnstrøm, S., Thorsgaard, N., Krabbe, S., Andersen, V., Dahlerup, J. F., Kjeldsen, J., Salupere, R., Olsen, J., Nielsen, K. R., ... EpiCom Group (2015). Costs and Resource Utilization for Diagnosis and Treatment During the Initial Year in a European Inflammatory Bowel Disease Inception Cohort: An ECCO-EpiCom Study. Inflammatory Bowel Diseases, 21(1), 121-131. https://doi.org/10.1097/mib.0000000000000250

Costs and Resource Utilization for Diagnosis and Treatment During the Initial Year in a European Inflammatory Bowel Disease Inception Cohort: An ECCO-EpiCom Study. / Burisch, J.; Vardi, Hillel; Pedersen, Natalia et al.
In: Inflammatory Bowel Diseases, Vol. 21, No. 1, 01.01.2015, p. 121-131.

Research output: Contribution to journal › Journal article › Research › peer-review

Burisch, J, Vardi, H, Pedersen, N, Brinar, M, Cukovic-Cavka, S, Kaimakliotis, I, Duricova, D, Bortlik, M, Shonová, O, Vind, I, Avnstrøm, S, Thorsgaard, N, Krabbe, S, Andersen, V, Dahlerup, JF, Kjeldsen, J, Salupere, R, Olsen, J, Nielsen, KR, Manninen, P, Collin, P, Katsanos, KH, Tsianos, EV, Ladefoged, K, Lakatos, L, Bailey, Y, OʼMorain, C, Schwartz, D, Lupinacci, G, De Padova, A, Jonaitis, L, Kupcinskas, L, Turcan, S, Barros, L, Magro, F, Lazar, D, Goldis, A, Nikulina, I, Belousova, E, Fernandez, A, Pineda, JR, Almer, S, Halfvarson, J, Tsai, H-H, Sebastian, S, Friger, M, Greenberg, D, Lakatos, PL, Langholz, E, Munkholm, P & EpiCom Group 2015, 'Costs and Resource Utilization for Diagnosis and Treatment During the Initial Year in a European Inflammatory Bowel Disease Inception Cohort: An ECCO-EpiCom Study', Inflammatory Bowel Diseases, vol. 21, no. 1, pp. 121-131. https://doi.org/10.1097/mib.0000000000000250

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title = "Costs and Resource Utilization for Diagnosis and Treatment During the Initial Year in a European Inflammatory Bowel Disease Inception Cohort: An ECCO-EpiCom Study",

abstract = "Background: No direct comparison of health care cost in patients with inflammatory bowel disease across the European continent exists. The aim of this study was to assess the costs of investigations and treatment for diagnostics and during the first year after diagnosis in Europe. Methods: The EpiCom cohort is a prospective population-based inception cohort of unselected inflammatory bowel disease patients from 31 Western and Eastern European centers. Patients were followed every third month from diagnosis, and clinical data regarding treatment and investigations were collected. Costs were calculated in euros (€) using the Danish Health Costs Register. Results: One thousand three hundred sixty-seven patients were followed, 710 with ulcerative colitis, 509 with Crohn's disease, and 148 with inflammatory bowel disease unclassified. Total expenditure for the cohort was €5,408,174 (investigations: €2,042,990 [38%], surgery: €1,427,648 [26%], biologicals: €781,089 [14%], and standard treatment: €1,156,520 [22%)]). Mean crude expenditure per patient in Western Europe (Eastern Europe) with Crohn's disease: investigations €1803 (€2160) (P = 0.44), surgery €11,489 (€13,973) (P = 0.14), standard treatment €1027 (€824) (P = 0.51), and biologicals €7376 (€8307) (P = 0.31). Mean crude expenditure per patient in Western Europe (Eastern Europe) with ulcerative colitis: investigations €1189 (€1518) (P < 0.01), surgery €18,414 (€12,395) (P = 0.18), standard treatment €896 (€798) (P < 0.05), and biologicals €5681 (€72) (P = 0.51). Conclusions: In this population-based unselected cohort, costs during the first year of disease were mainly incurred by investigative procedures and surgeries. However, biologicals accounted for >15% of costs. Long-term follow-up of the cohort is needed to assess the cost-effectiveness of biological agents.",

keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Cohort Studies, Europe, Female, Follow-Up Studies, Health Care Costs, Health Resources, Humans, Inflammatory Bowel Diseases, Male, Middle Aged, Prognosis, Surveys and Questionnaires, Time Factors, Young Adult",

author = "J. Burisch and Hillel Vardi and Natalia Pedersen and Marko Brinar and Silvja Cukovic-Cavka and Ioannis Kaimakliotis and Dana Duricova and Martin Bortlik and Olga Shonov{\'a} and Ida Vind and S{\o}ren Avnstr{\o}m and Niels Thorsgaard and Susanne Krabbe and Vibeke Andersen and Dahlerup, {Jens F} and Jens Kjeldsen and Riina Salupere and J{\'o}nger Olsen and Nielsen, {K{\'a}ri R} and Pia Manninen and Pekka Collin and Katsanos, {Konstantinnos H} and Tsianos, {Epameinondas V} and Karin Ladefoged and Laszlo Lakatos and Yvonne Bailey and Colm OʼMorain and Doron Schwartz and Guido Lupinacci and {De Padova}, Angelo and Laimas Jonaitis and Limas Kupcinskas and Svetlana Turcan and Louisa Barros and Fernando Magro and Daniela Lazar and Adrian Goldis and Inna Nikulina and Elena Belousova and Alberto Fernandez and Pineda, {Juan R} and Sven Almer and Jonas Halfvarson and Her-Hsin Tsai and Shaji Sebastian and Michael Friger and Dan Greenberg and Lakatos, {Peter L} and Ebbe Langholz and Pia Munkholm and {EpiCom Group}",

year = "2015",

month = jan,

day = "1",

doi = "10.1097/mib.0000000000000250",

language = "English",

volume = "21",

pages = "121--131",

journal = "Inflammatory Bowel Diseases",

issn = "1078-0998",

publisher = "Lippincott Williams & Wilkins",

number = "1",

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TY - JOUR

T1 - Costs and Resource Utilization for Diagnosis and Treatment During the Initial Year in a European Inflammatory Bowel Disease Inception Cohort

T2 - An ECCO-EpiCom Study

AU - Burisch, J.

AU - Vardi, Hillel

AU - Pedersen, Natalia

AU - Brinar, Marko

AU - Cukovic-Cavka, Silvja

AU - Kaimakliotis, Ioannis

AU - Duricova, Dana

AU - Bortlik, Martin

AU - Shonová, Olga

AU - Vind, Ida

AU - Avnstrøm, Søren

AU - Thorsgaard, Niels

AU - Krabbe, Susanne

AU - Andersen, Vibeke

AU - Dahlerup, Jens F

AU - Kjeldsen, Jens

AU - Salupere, Riina

AU - Olsen, Jónger

AU - Nielsen, Kári R

AU - Manninen, Pia

AU - Collin, Pekka

AU - Katsanos, Konstantinnos H

AU - Tsianos, Epameinondas V

AU - Ladefoged, Karin

AU - Lakatos, Laszlo

AU - Bailey, Yvonne

AU - OʼMorain, Colm

AU - Schwartz, Doron

AU - Lupinacci, Guido

AU - De Padova, Angelo

AU - Jonaitis, Laimas

AU - Kupcinskas, Limas

AU - Turcan, Svetlana

AU - Barros, Louisa

AU - Magro, Fernando

AU - Lazar, Daniela

AU - Goldis, Adrian

AU - Nikulina, Inna

AU - Belousova, Elena

AU - Fernandez, Alberto

AU - Pineda, Juan R

AU - Almer, Sven

AU - Halfvarson, Jonas

AU - Tsai, Her-Hsin

AU - Sebastian, Shaji

AU - Friger, Michael

AU - Greenberg, Dan

AU - Lakatos, Peter L

AU - Langholz, Ebbe

AU - Munkholm, Pia

AU - EpiCom Group

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background: No direct comparison of health care cost in patients with inflammatory bowel disease across the European continent exists. The aim of this study was to assess the costs of investigations and treatment for diagnostics and during the first year after diagnosis in Europe. Methods: The EpiCom cohort is a prospective population-based inception cohort of unselected inflammatory bowel disease patients from 31 Western and Eastern European centers. Patients were followed every third month from diagnosis, and clinical data regarding treatment and investigations were collected. Costs were calculated in euros (€) using the Danish Health Costs Register. Results: One thousand three hundred sixty-seven patients were followed, 710 with ulcerative colitis, 509 with Crohn's disease, and 148 with inflammatory bowel disease unclassified. Total expenditure for the cohort was €5,408,174 (investigations: €2,042,990 [38%], surgery: €1,427,648 [26%], biologicals: €781,089 [14%], and standard treatment: €1,156,520 [22%)]). Mean crude expenditure per patient in Western Europe (Eastern Europe) with Crohn's disease: investigations €1803 (€2160) (P = 0.44), surgery €11,489 (€13,973) (P = 0.14), standard treatment €1027 (€824) (P = 0.51), and biologicals €7376 (€8307) (P = 0.31). Mean crude expenditure per patient in Western Europe (Eastern Europe) with ulcerative colitis: investigations €1189 (€1518) (P < 0.01), surgery €18,414 (€12,395) (P = 0.18), standard treatment €896 (€798) (P < 0.05), and biologicals €5681 (€72) (P = 0.51). Conclusions: In this population-based unselected cohort, costs during the first year of disease were mainly incurred by investigative procedures and surgeries. However, biologicals accounted for >15% of costs. Long-term follow-up of the cohort is needed to assess the cost-effectiveness of biological agents.

AB - Background: No direct comparison of health care cost in patients with inflammatory bowel disease across the European continent exists. The aim of this study was to assess the costs of investigations and treatment for diagnostics and during the first year after diagnosis in Europe. Methods: The EpiCom cohort is a prospective population-based inception cohort of unselected inflammatory bowel disease patients from 31 Western and Eastern European centers. Patients were followed every third month from diagnosis, and clinical data regarding treatment and investigations were collected. Costs were calculated in euros (€) using the Danish Health Costs Register. Results: One thousand three hundred sixty-seven patients were followed, 710 with ulcerative colitis, 509 with Crohn's disease, and 148 with inflammatory bowel disease unclassified. Total expenditure for the cohort was €5,408,174 (investigations: €2,042,990 [38%], surgery: €1,427,648 [26%], biologicals: €781,089 [14%], and standard treatment: €1,156,520 [22%)]). Mean crude expenditure per patient in Western Europe (Eastern Europe) with Crohn's disease: investigations €1803 (€2160) (P = 0.44), surgery €11,489 (€13,973) (P = 0.14), standard treatment €1027 (€824) (P = 0.51), and biologicals €7376 (€8307) (P = 0.31). Mean crude expenditure per patient in Western Europe (Eastern Europe) with ulcerative colitis: investigations €1189 (€1518) (P < 0.01), surgery €18,414 (€12,395) (P = 0.18), standard treatment €896 (€798) (P < 0.05), and biologicals €5681 (€72) (P = 0.51). Conclusions: In this population-based unselected cohort, costs during the first year of disease were mainly incurred by investigative procedures and surgeries. However, biologicals accounted for >15% of costs. Long-term follow-up of the cohort is needed to assess the cost-effectiveness of biological agents.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Cohort Studies

KW - Europe

KW - Female

KW - Follow-Up Studies

KW - Health Care Costs

KW - Health Resources

KW - Humans

KW - Inflammatory Bowel Diseases

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Surveys and Questionnaires

KW - Time Factors

KW - Young Adult

U2 - 10.1097/mib.0000000000000250

DO - 10.1097/mib.0000000000000250

M3 - Journal article

C2 - 25437816

SN - 1078-0998

VL - 21

SP - 121

EP - 131

JO - Inflammatory Bowel Diseases

JF - Inflammatory Bowel Diseases

IS - 1

ER -

Costs and Resource Utilization for Diagnosis and Treatment During the Initial Year in a European Inflammatory Bowel Disease Inception Cohort: An ECCO-EpiCom Study

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Keywords

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