Correlations between serum levels of beta amyloid, cerebrospinal levels of tau and phospho tau, and delayed response tasks in young and aged cynomolgus monkeys (Macaca fascicularis)

Huda Shalahudin Darusman; D Sajuthi; O Kalliokoski; K R Jacobsen; J Call; S J Schapiro; A Gjedde; K S P Abelson; J Hau

doi:10.1111/jmp.12044

Correlations between serum levels of beta amyloid, cerebrospinal levels of tau and phospho tau, and delayed response tasks in young and aged cynomolgus monkeys (Macaca fascicularis)

Huda Shalahudin Darusman, D Sajuthi, O Kalliokoski, K R Jacobsen, J Call, S J Schapiro, A Gjedde, K S P Abelson, J Hau

9 Citations (Scopus)

Abstract

Background: In an attempt to explore cynomolgus monkeys as an animal model for Alzheimer's disease, the present study focused on the Alzheimer's biomarkers beta amyloid 1-42 (Aβ₄₂) in serum, and total tau (t-tau) and phosphorylated tau (p-tau) levels in cerebrospinal fluid. Methods: We measured biomarker levels in Young and Aged cynomolgus monkeys and correlated these with performance on three delayed response tasks. Results: The Aβ₄₂ concentration of the Aged monkeys was significantly lower than in the Young subjects, while the t-tau and p-tau did not significantly differ between the groups. The Young subjects performed significantly better than the Aged individuals on the memory tests. Only Aβ₄₂ levels were significantly correlated with performance in the three delayed response tasks. Conclusions: Circulating Aβ₄₂ levels were lower in Aged monkeys and were correlated with inferior performance on delayed response tasks in Aged animals; therefore, both measures may be useful in establishing cynomolgus monkeys as models for studies of AD.

Original language	English
Journal	Journal of Medical Primatology
Volume	42
Issue number	3
Pages (from-to)	137-46
Number of pages	10
ISSN	0047-2565
DOIs	https://doi.org/10.1111/jmp.12044
Publication status	Published - Jun 2013

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Darusman, H. S., Sajuthi, D., Kalliokoski, O., Jacobsen, K. R., Call, J., Schapiro, S. J., Gjedde, A., Abelson, K. S. P., & Hau, J. (2013). Correlations between serum levels of beta amyloid, cerebrospinal levels of tau and phospho tau, and delayed response tasks in young and aged cynomolgus monkeys (Macaca fascicularis). Journal of Medical Primatology, 42(3), 137-46. https://doi.org/10.1111/jmp.12044

Correlations between serum levels of beta amyloid, cerebrospinal levels of tau and phospho tau, and delayed response tasks in young and aged cynomolgus monkeys (Macaca fascicularis). / Darusman, Huda Shalahudin; Sajuthi, D; Kalliokoski, O et al.

In: Journal of Medical Primatology, Vol. 42, No. 3, 06.2013, p. 137-46.

Research output: Contribution to journal › Journal article › Research › peer-review

Darusman, HS, Sajuthi, D, Kalliokoski, O, Jacobsen, KR, Call, J, Schapiro, SJ, Gjedde, A , Abelson, KSP & Hau, J 2013, 'Correlations between serum levels of beta amyloid, cerebrospinal levels of tau and phospho tau, and delayed response tasks in young and aged cynomolgus monkeys (Macaca fascicularis)', Journal of Medical Primatology, vol. 42, no. 3, pp. 137-46. https://doi.org/10.1111/jmp.12044

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title = "Correlations between serum levels of beta amyloid, cerebrospinal levels of tau and phospho tau, and delayed response tasks in young and aged cynomolgus monkeys (Macaca fascicularis)",

abstract = "Background: In an attempt to explore cynomolgus monkeys as an animal model for Alzheimer's disease, the present study focused on the Alzheimer's biomarkers beta amyloid 1-42 (Aβ42) in serum, and total tau (t-tau) and phosphorylated tau (p-tau) levels in cerebrospinal fluid. Methods: We measured biomarker levels in Young and Aged cynomolgus monkeys and correlated these with performance on three delayed response tasks. Results: The Aβ42 concentration of the Aged monkeys was significantly lower than in the Young subjects, while the t-tau and p-tau did not significantly differ between the groups. The Young subjects performed significantly better than the Aged individuals on the memory tests. Only Aβ42 levels were significantly correlated with performance in the three delayed response tasks. Conclusions: Circulating Aβ42 levels were lower in Aged monkeys and were correlated with inferior performance on delayed response tasks in Aged animals; therefore, both measures may be useful in establishing cynomolgus monkeys as models for studies of AD.",

author = "Darusman, {Huda Shalahudin} and D Sajuthi and O Kalliokoski and Jacobsen, {K R} and J Call and Schapiro, {S J} and A Gjedde and Abelson, {K S P} and J Hau",

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T1 - Correlations between serum levels of beta amyloid, cerebrospinal levels of tau and phospho tau, and delayed response tasks in young and aged cynomolgus monkeys (Macaca fascicularis)

AU - Darusman, Huda Shalahudin

AU - Sajuthi, D

AU - Kalliokoski, O

AU - Jacobsen, K R

AU - Call, J

AU - Schapiro, S J

AU - Gjedde, A

AU - Abelson, K S P

AU - Hau, J

PY - 2013/6

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N2 - Background: In an attempt to explore cynomolgus monkeys as an animal model for Alzheimer's disease, the present study focused on the Alzheimer's biomarkers beta amyloid 1-42 (Aβ42) in serum, and total tau (t-tau) and phosphorylated tau (p-tau) levels in cerebrospinal fluid. Methods: We measured biomarker levels in Young and Aged cynomolgus monkeys and correlated these with performance on three delayed response tasks. Results: The Aβ42 concentration of the Aged monkeys was significantly lower than in the Young subjects, while the t-tau and p-tau did not significantly differ between the groups. The Young subjects performed significantly better than the Aged individuals on the memory tests. Only Aβ42 levels were significantly correlated with performance in the three delayed response tasks. Conclusions: Circulating Aβ42 levels were lower in Aged monkeys and were correlated with inferior performance on delayed response tasks in Aged animals; therefore, both measures may be useful in establishing cynomolgus monkeys as models for studies of AD.

AB - Background: In an attempt to explore cynomolgus monkeys as an animal model for Alzheimer's disease, the present study focused on the Alzheimer's biomarkers beta amyloid 1-42 (Aβ42) in serum, and total tau (t-tau) and phosphorylated tau (p-tau) levels in cerebrospinal fluid. Methods: We measured biomarker levels in Young and Aged cynomolgus monkeys and correlated these with performance on three delayed response tasks. Results: The Aβ42 concentration of the Aged monkeys was significantly lower than in the Young subjects, while the t-tau and p-tau did not significantly differ between the groups. The Young subjects performed significantly better than the Aged individuals on the memory tests. Only Aβ42 levels were significantly correlated with performance in the three delayed response tasks. Conclusions: Circulating Aβ42 levels were lower in Aged monkeys and were correlated with inferior performance on delayed response tasks in Aged animals; therefore, both measures may be useful in establishing cynomolgus monkeys as models for studies of AD.

U2 - 10.1111/jmp.12044

DO - 10.1111/jmp.12044

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SN - 0047-2565

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JO - Journal of Medical Primatology

JF - Journal of Medical Primatology

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ER -

Correlations between serum levels of beta amyloid, cerebrospinal levels of tau and phospho tau, and delayed response tasks in young and aged cynomolgus monkeys (Macaca fascicularis)

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