Correlates of whole-blood polyunsaturated fatty acids among young children with moderate acute malnutrition

Charles W Yaméogo; Bernardette Cichon; Christian Fabiansen; Maren Johanne Heilskov Rytter; Daniel Faurholt-Jepsen; K D Stark; André Briend; S Shepherd; A S Traoré; Vibeke Bak Christensen; Kim F. Michaelsen; Henrik Friis; Lotte Lauritzen

doi:10.1186/s12937-017-0264-3

Correlates of whole-blood polyunsaturated fatty acids among young children with moderate acute malnutrition

Charles W Yaméogo, Bernardette Cichon, Christian Fabiansen, Maren Johanne Heilskov Rytter, Daniel Faurholt-Jepsen, K D Stark, André Briend, S Shepherd, A S Traoré, Vibeke Bak Christensen, Kim F. Michaelsen, Henrik Friis, Lotte Lauritzen

Lifecourse Nutrition & Health

7 Citations (Scopus)

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Abstract

BACKGROUND: Severe acute malnutrition (SAM) has been associated with low polyunsaturated fatty acid (PUFA) status. However, investigations regarding PUFA status and correlates in children with moderate acute malnutrition (MAM) from low-income countries are scarce. The aim of this study was to describe whole-blood PUFA levels in children with moderate acute malnutrition (MAM) and to identify correlates of PUFAs.

METHODS: We conducted a cross-sectional study using baseline data from a prospective nutritional intervention trial among 1609 children with MAM aged 6-23 months in Burkina Faso,West Africa. Whole-blood PUFAs were measured by gas chromatography and expressed as percent of total whole-blood fatty acids (FA%). Potential correlates of PUFAs including infection, inflammation, hemoglobin, anthropometry (difference between children diagnosed as having MAM based on low mid-upper-arm-circumference (MUAC) only, low MUAC and weight-for-height z-score (WHZ), or low WHZ only) and diet were assessed by linear regression adjusted for age and sex.

RESULTS: Children with MAM had low concentrations of whole-blood PUFAs, particularly n-3 PUFAs. Moreover, children diagnosed with MAM based only on low MUAC had 0.32 (95% confidence interval (CI), 0.14; 0.50) and 0.40 (95% CI, 0.16; 0.63) FA% lower arachidonic acid (AA) than those recruited based on both low WHZ as well as low MUAC and those recruited with low WHZ only, respectively. Infection and inflammation were associated with low levels of all long-chain (LC)-PUFAs, while hemoglobin was positively associated with whole-blood LC-PUFAs.

CONCLUSION: While PUFA deficiency was not a general problem, overall whole-blood PUFA concentrations, especially of n-3 PUFAs, were low. Infection, inflammation, hemoglobin, anthropometry and diet were correlates of PUFAs concentrations in children with MAM.

TRIAL REGISTRATION: The trial is registered at http://www.isrctn.com ( ISRCTN42569496 ).

Original language	English
Article number	44
Journal	Nutrition Journal
Volume	16
Number of pages	11
ISSN	1475-2891
DOIs	https://doi.org/10.1186/s12937-017-0264-3
Publication status	Published - 13 Jul 2017

Keywords

Essential fatty acids
Undernourished children
Diet
Morbidity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

Yaméogo, C. W., Cichon, B., Fabiansen, C., Rytter, M. J. H., Faurholt-Jepsen, D., Stark, K. D., Briend, A., Shepherd, S., Traoré, A. S., Christensen, V. B., Michaelsen, K. F., Friis, H., & Lauritzen, L. (2017). Correlates of whole-blood polyunsaturated fatty acids among young children with moderate acute malnutrition. Nutrition Journal, 16, [44]. https://doi.org/10.1186/s12937-017-0264-3

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title = "Correlates of whole-blood polyunsaturated fatty acids among young children with moderate acute malnutrition",

abstract = "BACKGROUND: Severe acute malnutrition (SAM) has been associated with low polyunsaturated fatty acid (PUFA) status. However, investigations regarding PUFA status and correlates in children with moderate acute malnutrition (MAM) from low-income countries are scarce. The aim of this study was to describe whole-blood PUFA levels in children with moderate acute malnutrition (MAM) and to identify correlates of PUFAs.METHODS: We conducted a cross-sectional study using baseline data from a prospective nutritional intervention trial among 1609 children with MAM aged 6-23 months in Burkina Faso,West Africa. Whole-blood PUFAs were measured by gas chromatography and expressed as percent of total whole-blood fatty acids (FA%). Potential correlates of PUFAs including infection, inflammation, hemoglobin, anthropometry (difference between children diagnosed as having MAM based on low mid-upper-arm-circumference (MUAC) only, low MUAC and weight-for-height z-score (WHZ), or low WHZ only) and diet were assessed by linear regression adjusted for age and sex.RESULTS: Children with MAM had low concentrations of whole-blood PUFAs, particularly n-3 PUFAs. Moreover, children diagnosed with MAM based only on low MUAC had 0.32 (95% confidence interval (CI), 0.14; 0.50) and 0.40 (95% CI, 0.16; 0.63) FA% lower arachidonic acid (AA) than those recruited based on both low WHZ as well as low MUAC and those recruited with low WHZ only, respectively. Infection and inflammation were associated with low levels of all long-chain (LC)-PUFAs, while hemoglobin was positively associated with whole-blood LC-PUFAs.CONCLUSION: While PUFA deficiency was not a general problem, overall whole-blood PUFA concentrations, especially of n-3 PUFAs, were low. Infection, inflammation, hemoglobin, anthropometry and diet were correlates of PUFAs concentrations in children with MAM.TRIAL REGISTRATION: The trial is registered at http://www.isrctn.com ( ISRCTN42569496 ).",

keywords = "Essential fatty acids, Undernourished children, Diet, Morbidity",

author = "Yam{\'e}ogo, {Charles W} and Bernardette Cichon and Christian Fabiansen and Rytter, {Maren Johanne Heilskov} and Daniel Faurholt-Jepsen and Stark, {K D} and Andr{\'e} Briend and S Shepherd and Traor{\'e}, {A S} and Christensen, {Vibeke Bak} and Michaelsen, {Kim F.} and Henrik Friis and Lotte Lauritzen",

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year = "2017",

month = jul,

day = "13",

doi = "10.1186/s12937-017-0264-3",

language = "English",

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journal = "Nutrition Journal",

issn = "1475-2891",

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TY - JOUR

T1 - Correlates of whole-blood polyunsaturated fatty acids among young children with moderate acute malnutrition

AU - Yaméogo, Charles W

AU - Cichon, Bernardette

AU - Fabiansen, Christian

AU - Rytter, Maren Johanne Heilskov

AU - Faurholt-Jepsen, Daniel

AU - Stark, K D

AU - Briend, André

AU - Shepherd, S

AU - Traoré, A S

AU - Christensen, Vibeke Bak

AU - Michaelsen, Kim F.

AU - Friis, Henrik

AU - Lauritzen, Lotte

N1 - CURIS 2017 NEXS 197

PY - 2017/7/13

Y1 - 2017/7/13

N2 - BACKGROUND: Severe acute malnutrition (SAM) has been associated with low polyunsaturated fatty acid (PUFA) status. However, investigations regarding PUFA status and correlates in children with moderate acute malnutrition (MAM) from low-income countries are scarce. The aim of this study was to describe whole-blood PUFA levels in children with moderate acute malnutrition (MAM) and to identify correlates of PUFAs.METHODS: We conducted a cross-sectional study using baseline data from a prospective nutritional intervention trial among 1609 children with MAM aged 6-23 months in Burkina Faso,West Africa. Whole-blood PUFAs were measured by gas chromatography and expressed as percent of total whole-blood fatty acids (FA%). Potential correlates of PUFAs including infection, inflammation, hemoglobin, anthropometry (difference between children diagnosed as having MAM based on low mid-upper-arm-circumference (MUAC) only, low MUAC and weight-for-height z-score (WHZ), or low WHZ only) and diet were assessed by linear regression adjusted for age and sex.RESULTS: Children with MAM had low concentrations of whole-blood PUFAs, particularly n-3 PUFAs. Moreover, children diagnosed with MAM based only on low MUAC had 0.32 (95% confidence interval (CI), 0.14; 0.50) and 0.40 (95% CI, 0.16; 0.63) FA% lower arachidonic acid (AA) than those recruited based on both low WHZ as well as low MUAC and those recruited with low WHZ only, respectively. Infection and inflammation were associated with low levels of all long-chain (LC)-PUFAs, while hemoglobin was positively associated with whole-blood LC-PUFAs.CONCLUSION: While PUFA deficiency was not a general problem, overall whole-blood PUFA concentrations, especially of n-3 PUFAs, were low. Infection, inflammation, hemoglobin, anthropometry and diet were correlates of PUFAs concentrations in children with MAM.TRIAL REGISTRATION: The trial is registered at http://www.isrctn.com ( ISRCTN42569496 ).

AB - BACKGROUND: Severe acute malnutrition (SAM) has been associated with low polyunsaturated fatty acid (PUFA) status. However, investigations regarding PUFA status and correlates in children with moderate acute malnutrition (MAM) from low-income countries are scarce. The aim of this study was to describe whole-blood PUFA levels in children with moderate acute malnutrition (MAM) and to identify correlates of PUFAs.METHODS: We conducted a cross-sectional study using baseline data from a prospective nutritional intervention trial among 1609 children with MAM aged 6-23 months in Burkina Faso,West Africa. Whole-blood PUFAs were measured by gas chromatography and expressed as percent of total whole-blood fatty acids (FA%). Potential correlates of PUFAs including infection, inflammation, hemoglobin, anthropometry (difference between children diagnosed as having MAM based on low mid-upper-arm-circumference (MUAC) only, low MUAC and weight-for-height z-score (WHZ), or low WHZ only) and diet were assessed by linear regression adjusted for age and sex.RESULTS: Children with MAM had low concentrations of whole-blood PUFAs, particularly n-3 PUFAs. Moreover, children diagnosed with MAM based only on low MUAC had 0.32 (95% confidence interval (CI), 0.14; 0.50) and 0.40 (95% CI, 0.16; 0.63) FA% lower arachidonic acid (AA) than those recruited based on both low WHZ as well as low MUAC and those recruited with low WHZ only, respectively. Infection and inflammation were associated with low levels of all long-chain (LC)-PUFAs, while hemoglobin was positively associated with whole-blood LC-PUFAs.CONCLUSION: While PUFA deficiency was not a general problem, overall whole-blood PUFA concentrations, especially of n-3 PUFAs, were low. Infection, inflammation, hemoglobin, anthropometry and diet were correlates of PUFAs concentrations in children with MAM.TRIAL REGISTRATION: The trial is registered at http://www.isrctn.com ( ISRCTN42569496 ).

KW - Essential fatty acids

KW - Undernourished children

KW - Diet

KW - Morbidity

U2 - 10.1186/s12937-017-0264-3

DO - 10.1186/s12937-017-0264-3

M3 - Journal article

C2 - 28705254

SN - 1475-2891

VL - 16

JO - Nutrition Journal

JF - Nutrition Journal

M1 - 44

ER -

Correlates of whole-blood polyunsaturated fatty acids among young children with moderate acute malnutrition

Abstract

Keywords

UN SDGs

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