Corpus callosum tissue loss and development of motor and global cognitive impairment: the LADIS study

Kristian S Frederiksen; Ellen Garde; Arnold Skimminge; Frederik Barkhof; Philip Scheltens; Elisabeth C W van Straaten; Franz Fazekas; Hansjörg Baezner; Ana Verdelho; José M Ferro; Timo Erkinjuntti; Hanna Jokinen; Lars-Olof Wahlund; John T O'Brien; Anna M Basile; Leonardo Pantoni; Domenico Inzitari; Gunhild Waldemar

doi:http://dx.doi.org/10.1159/000334949

Corpus callosum tissue loss and development of motor and global cognitive impairment: the LADIS study

Kristian S Frederiksen, Ellen Garde, Arnold Skimminge, Frederik Barkhof, Philip Scheltens, Elisabeth C W van Straaten, Franz Fazekas, Hansjörg Baezner, Ana Verdelho, José M Ferro, Timo Erkinjuntti, Hanna Jokinen, Lars-Olof Wahlund, John T O'Brien, Anna M Basile, Leonardo Pantoni, Domenico Inzitari, Gunhild Waldemar

18 Citations (Scopus)

Abstract

Objective: To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly. Methods: This study was based on the Leukoaraiosis and Disability (LADIS) study. Assessment of cognitive and motor functions and magnetic resonance imaging (MRI) were done at baseline and at a 3-year follow-up in nondemented elderly subjects. Results: 328 of 639 LADIS subjects had MRIs at baseline and at the 3-year follow-up, which allowed for assessment of CC. Logistic regression revealed differential tissue loss rates in posterior CC in subjects converting to dementia, compared to nonconverters (p < 0.05). Anterior and posterior CC tissue loss was significantly correlated with self-perceived memory impairment in nonconverters (p < 0.05). CC tissue loss was also significantly associated with impaired single leg stance time (p < 0.01). Conclusion: The present longitudinal study on CC supports the role of callosal tissue loss in the development of global cognitive as well as motor impairment.

Original language	English
Journal	Dementia and Geriatric Cognitive Disorders
Volume	32
Issue number	4
Pages (from-to)	279-86
Number of pages	8
ISSN	1420-8008
DOIs	https://doi.org/10.1159/000334949
Publication status	Published - Feb 2012

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Frederiksen, K. S., Garde, E., Skimminge, A., Barkhof, F., Scheltens, P., van Straaten, E. C. W., Fazekas, F., Baezner, H., Verdelho, A., Ferro, J. M., Erkinjuntti, T., Jokinen, H., Wahlund, L-O., O'Brien, J. T., Basile, A. M., Pantoni, L., Inzitari, D., & Waldemar, G. (2012). Corpus callosum tissue loss and development of motor and global cognitive impairment: the LADIS study. Dementia and Geriatric Cognitive Disorders, 32(4), 279-86. https://doi.org/10.1159/000334949

Frederiksen, KS, Garde, E, Skimminge, A, Barkhof, F, Scheltens, P, van Straaten, ECW, Fazekas, F, Baezner, H, Verdelho, A, Ferro, JM, Erkinjuntti, T, Jokinen, H, Wahlund, L-O, O'Brien, JT, Basile, AM, Pantoni, L, Inzitari, D & Waldemar, G 2012, 'Corpus callosum tissue loss and development of motor and global cognitive impairment: the LADIS study', Dementia and Geriatric Cognitive Disorders, vol. 32, no. 4, pp. 279-86. https://doi.org/10.1159/000334949

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title = "Corpus callosum tissue loss and development of motor and global cognitive impairment: the LADIS study",

abstract = "Objective: To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly. Methods: This study was based on the Leukoaraiosis and Disability (LADIS) study. Assessment of cognitive and motor functions and magnetic resonance imaging (MRI) were done at baseline and at a 3-year follow-up in nondemented elderly subjects. Results: 328 of 639 LADIS subjects had MRIs at baseline and at the 3-year follow-up, which allowed for assessment of CC. Logistic regression revealed differential tissue loss rates in posterior CC in subjects converting to dementia, compared to nonconverters (p < 0.05). Anterior and posterior CC tissue loss was significantly correlated with self-perceived memory impairment in nonconverters (p < 0.05). CC tissue loss was also significantly associated with impaired single leg stance time (p < 0.01). Conclusion: The present longitudinal study on CC supports the role of callosal tissue loss in the development of global cognitive as well as motor impairment.",

author = "Frederiksen, {Kristian S} and Ellen Garde and Arnold Skimminge and Frederik Barkhof and Philip Scheltens and {van Straaten}, {Elisabeth C W} and Franz Fazekas and Hansj{\"o}rg Baezner and Ana Verdelho and Ferro, {Jos{\'e} M} and Timo Erkinjuntti and Hanna Jokinen and Lars-Olof Wahlund and O'Brien, {John T} and Basile, {Anna M} and Leonardo Pantoni and Domenico Inzitari and Gunhild Waldemar",

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year = "2012",

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doi = "http://dx.doi.org/10.1159/000334949",

language = "English",

volume = "32",

pages = "279--86",

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T1 - Corpus callosum tissue loss and development of motor and global cognitive impairment

T2 - the LADIS study

AU - Frederiksen, Kristian S

AU - Garde, Ellen

AU - Skimminge, Arnold

AU - Barkhof, Frederik

AU - Scheltens, Philip

AU - van Straaten, Elisabeth C W

AU - Fazekas, Franz

AU - Baezner, Hansjörg

AU - Verdelho, Ana

AU - Ferro, José M

AU - Erkinjuntti, Timo

AU - Jokinen, Hanna

AU - Wahlund, Lars-Olof

AU - O'Brien, John T

AU - Basile, Anna M

AU - Pantoni, Leonardo

AU - Inzitari, Domenico

AU - Waldemar, Gunhild

PY - 2012/2

Y1 - 2012/2

N2 - Objective: To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly. Methods: This study was based on the Leukoaraiosis and Disability (LADIS) study. Assessment of cognitive and motor functions and magnetic resonance imaging (MRI) were done at baseline and at a 3-year follow-up in nondemented elderly subjects. Results: 328 of 639 LADIS subjects had MRIs at baseline and at the 3-year follow-up, which allowed for assessment of CC. Logistic regression revealed differential tissue loss rates in posterior CC in subjects converting to dementia, compared to nonconverters (p < 0.05). Anterior and posterior CC tissue loss was significantly correlated with self-perceived memory impairment in nonconverters (p < 0.05). CC tissue loss was also significantly associated with impaired single leg stance time (p < 0.01). Conclusion: The present longitudinal study on CC supports the role of callosal tissue loss in the development of global cognitive as well as motor impairment.

AB - Objective: To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly. Methods: This study was based on the Leukoaraiosis and Disability (LADIS) study. Assessment of cognitive and motor functions and magnetic resonance imaging (MRI) were done at baseline and at a 3-year follow-up in nondemented elderly subjects. Results: 328 of 639 LADIS subjects had MRIs at baseline and at the 3-year follow-up, which allowed for assessment of CC. Logistic regression revealed differential tissue loss rates in posterior CC in subjects converting to dementia, compared to nonconverters (p < 0.05). Anterior and posterior CC tissue loss was significantly correlated with self-perceived memory impairment in nonconverters (p < 0.05). CC tissue loss was also significantly associated with impaired single leg stance time (p < 0.01). Conclusion: The present longitudinal study on CC supports the role of callosal tissue loss in the development of global cognitive as well as motor impairment.

U2 - http://dx.doi.org/10.1159/000334949

DO - http://dx.doi.org/10.1159/000334949

M3 - Journal article

SN - 1420-8008

VL - 32

SP - 279

EP - 286

JO - Dementia and Geriatric Cognitive Disorders

JF - Dementia and Geriatric Cognitive Disorders

IS - 4

ER -

Corpus callosum tissue loss and development of motor and global cognitive impairment: the LADIS study

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