Corpus callosum atrophy as a predictor of age-related cognitive and motor impairment: a 3-year follow-up of the LADIS study cohort

C Ryberg; E Rostrup; O B Paulson; F Barkhof; P Scheltens; E C W van Straaten; W M van der Flier; F Fazekas; R Schmidt; J M Ferro; H Baezner; T Erkinjuntti; H Jokinen; L-O Wahlund; A Poggesi; L Pantoni; D Inzitari; G Waldemar; LADIS study group; Bjørn Ebdrup

doi:10.1016/j.jns.2011.05.002

Corpus callosum atrophy as a predictor of age-related cognitive and motor impairment: a 3-year follow-up of the LADIS study cohort

C Ryberg, E Rostrup, O B Paulson, F Barkhof, P Scheltens, E C W van Straaten, W M van der Flier, F Fazekas, R Schmidt, J M Ferro, H Baezner, T Erkinjuntti, H Jokinen, L-O Wahlund, A Poggesi, L Pantoni, D Inzitari, G Waldemar, LADIS study group, Bjørn Ebdrup

54 Citations (Scopus)

Abstract

The aim of this 3-year follow-up study was to investigate whether corpus callosum (CC) atrophy may predict future motor and cognitive impairment in an elderly population. On baseline MRI from 563 subjects with age-related white matter changes (ARWMC) from the Leukoaraiosis And DISability (LADIS) study, the CC was segmented and subdivided into five anterior-posterior regions (CC1-CC5). Associations between the CC areas and decline in motor performance and cognitive functions over a 3-year period were analyzed. CC atrophy at baseline was significantly associated with impaired cognitive performance (p

Original language	English
Journal	Journal of the Neurological Sciences
Volume	307
Issue number	1-2
Pages (from-to)	100-5
Number of pages	6
ISSN	0022-510X
DOIs	https://doi.org/10.1016/j.jns.2011.05.002
Publication status	Published - 15 Aug 2011

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Ryberg, C., Rostrup, E., Paulson, O. B., Barkhof, F., Scheltens, P., van Straaten, E. C. W., van der Flier, W. M., Fazekas, F., Schmidt, R., Ferro, J. M., Baezner, H., Erkinjuntti, T., Jokinen, H., Wahlund, L-O., Poggesi, A., Pantoni, L., Inzitari, D., Waldemar, G., LADIS study group, & Ebdrup, B. (2011). Corpus callosum atrophy as a predictor of age-related cognitive and motor impairment: a 3-year follow-up of the LADIS study cohort. Journal of the Neurological Sciences, 307(1-2), 100-5. https://doi.org/10.1016/j.jns.2011.05.002

Ryberg, C, Rostrup, E, Paulson, OB, Barkhof, F, Scheltens, P, van Straaten, ECW, van der Flier, WM, Fazekas, F, Schmidt, R, Ferro, JM, Baezner, H, Erkinjuntti, T, Jokinen, H, Wahlund, L-O, Poggesi, A, Pantoni, L, Inzitari, D, Waldemar, G, LADIS study group & Ebdrup, B 2011, 'Corpus callosum atrophy as a predictor of age-related cognitive and motor impairment: a 3-year follow-up of the LADIS study cohort', Journal of the Neurological Sciences, vol. 307, no. 1-2, pp. 100-5. https://doi.org/10.1016/j.jns.2011.05.002

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title = "Corpus callosum atrophy as a predictor of age-related cognitive and motor impairment: a 3-year follow-up of the LADIS study cohort",

abstract = "The aim of this 3-year follow-up study was to investigate whether corpus callosum (CC) atrophy may predict future motor and cognitive impairment in an elderly population. On baseline MRI from 563 subjects with age-related white matter changes (ARWMC) from the Leukoaraiosis And DISability (LADIS) study, the CC was segmented and subdivided into five anterior-posterior regions (CC1-CC5). Associations between the CC areas and decline in motor performance and cognitive functions over a 3-year period were analyzed. CC atrophy at baseline was significantly associated with impaired cognitive performance (p",

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T1 - Corpus callosum atrophy as a predictor of age-related cognitive and motor impairment: a 3-year follow-up of the LADIS study cohort

AU - Ryberg, C

AU - Rostrup, E

AU - Paulson, O B

AU - Barkhof, F

AU - Scheltens, P

AU - van Straaten, E C W

AU - van der Flier, W M

AU - Fazekas, F

AU - Schmidt, R

AU - Ferro, J M

AU - Baezner, H

AU - Erkinjuntti, T

AU - Jokinen, H

AU - Wahlund, L-O

AU - Poggesi, A

AU - Pantoni, L

AU - Inzitari, D

AU - Waldemar, G

AU - LADIS study group

AU - Ebdrup, Bjørn

PY - 2011/8/15

Y1 - 2011/8/15

N2 - The aim of this 3-year follow-up study was to investigate whether corpus callosum (CC) atrophy may predict future motor and cognitive impairment in an elderly population. On baseline MRI from 563 subjects with age-related white matter changes (ARWMC) from the Leukoaraiosis And DISability (LADIS) study, the CC was segmented and subdivided into five anterior-posterior regions (CC1-CC5). Associations between the CC areas and decline in motor performance and cognitive functions over a 3-year period were analyzed. CC atrophy at baseline was significantly associated with impaired cognitive performance (p

AB - The aim of this 3-year follow-up study was to investigate whether corpus callosum (CC) atrophy may predict future motor and cognitive impairment in an elderly population. On baseline MRI from 563 subjects with age-related white matter changes (ARWMC) from the Leukoaraiosis And DISability (LADIS) study, the CC was segmented and subdivided into five anterior-posterior regions (CC1-CC5). Associations between the CC areas and decline in motor performance and cognitive functions over a 3-year period were analyzed. CC atrophy at baseline was significantly associated with impaired cognitive performance (p

U2 - 10.1016/j.jns.2011.05.002

DO - 10.1016/j.jns.2011.05.002

M3 - Journal article

SN - 0022-510X

VL - 307

SP - 100

EP - 105

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

IS - 1-2

ER -

Corpus callosum atrophy as a predictor of age-related cognitive and motor impairment: a 3-year follow-up of the LADIS study cohort

Abstract

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