Coronary and peripheral endothelial function in HIV patients studied with positron emission tomography and flow-mediated dilation: relation to hypercholesterolemia.

Anne-Mette Lebech; Ulrik Sloth Kristoffersen; Niels Wiinberg; Kristian Kofoed; Ove Andersen; Birger Hesse; Claus Leth Petersen; Jan Gerstoft; Andreas Kjær; Anne-Mette Lebech; Ulrik Kristoffersen; Niels Wiinberg; Kristian Kofoed; Ove Andersen; Birger Hesse; Claus Petersen; Jan Gerstoft; Andreas Kjær

doi:10.1007/s00259-008-0846-6

Coronary and peripheral endothelial function in HIV patients studied with positron emission tomography and flow-mediated dilation: relation to hypercholesterolemia.

Anne-Mette Lebech, Ulrik Sloth Kristoffersen, Niels Wiinberg, Kristian Kofoed, Ove Andersen, Birger Hesse, Claus Leth Petersen, Jan Gerstoft, Andreas Kjær, Anne-Mette Lebech, Ulrik Kristoffersen, Niels Wiinberg, Kristian Kofoed, Ove Andersen, Birger Hesse, Claus Petersen, Jan Gerstoft, Andreas Kjær

17 Citations (Scopus)

Abstract

BACKGROUND: The mechanisms underlying increased cardiovascular risk in HIV patients in antiretroviral therapy (ART) are not known. Our aim was to study the endothelial function of the coronary arteries by cardiac perfusion positron emission tomography (PET), in HIV patients with normal or high cholesterol levels. Flow mediated dilation (FMD) of the brachial artery and circulating endothelial markers were also assessed. METHODS AND RESULTS: HIV patients in ART with total cholesterol /= 6.5 mmol/L (254 mg/dL; n = 12) and healthy controls (n = 14) were included. (13)NH(3) perfusion PET, FMD, and measurement of plasma levels of E-Selectin, ICAM-1, VCAM-1, tPAI-1, and hs-CRP were performed. Baseline myocardial perfusion and the coronary flow reserve measured by PET (3.2 +/- 0.3, 3.2 +/- 0.3 and 3.0 +/- 0.3; ns) was similar in HIV patients with normal or high total cholesterol and controls. FMD did not differ between the groups and was 4.6 +/- 1.1%, 5.1 +/- 1.2%, and 4.6 +/- 0.8%, respectively. Increased levels of plasma E-Selectin, ICAM-1, tPAI-1, and hs-CRP were found in HIV patients when compared to controls (p < 0.05). E-Selectin and ICAM-1 levels were higher in HIV patients receiving protease inhibitors (PI) compared to those not receiving PI (p < 0.05). None of the measured endothelial biomarkers differed between the normal and high cholesterol HIV groups. CONCLUSIONS: In ART-treated HIV patients with a low overall cardiovascular risk, no sign of endothelial dysfunction was found not even in hypercholesterolemic patients. Also, the increased level of plasma endothelial markers found in HIV patients was not related to hypercholesterolemia.

Original language	English
Journal	European Journal of Nuclear Medicine and Molecular Imaging
Volume	35
Issue number	11
Pages (from-to)	2049-2058
ISSN	1619-7070
DOIs	https://doi.org/10.1007/s00259-008-0846-6 https://doi.org/10.1007/s00259-008-0846-6
Publication status	Published - 2008

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Lebech, A-M., Kristoffersen, U. S., Wiinberg, N., Kofoed, K., Andersen, O., Hesse, B., Petersen, C. L., Gerstoft, J., Kjær, A., Lebech, A-M., Kristoffersen, U., Wiinberg, N., Kofoed, K., Andersen, O., Hesse, B., Petersen, C., Gerstoft, J., & Kjær, A. (2008). Coronary and peripheral endothelial function in HIV patients studied with positron emission tomography and flow-mediated dilation: relation to hypercholesterolemia. European Journal of Nuclear Medicine and Molecular Imaging, 35(11), 2049-2058. https://doi.org/10.1007/s00259-008-0846-6, https://doi.org/10.1007/s00259-008-0846-6

Coronary and peripheral endothelial function in HIV patients studied with positron emission tomography and flow-mediated dilation: relation to hypercholesterolemia. / Lebech, Anne-Mette; Kristoffersen, Ulrik Sloth; Wiinberg, Niels et al.

In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 35, No. 11, 2008, p. 2049-2058.

Research output: Contribution to journal › Journal article › Research › peer-review

Lebech, A-M, Kristoffersen, US, Wiinberg, N, Kofoed, K, Andersen, O, Hesse, B, Petersen, CL, Gerstoft, J , Kjær, A, Lebech, A-M, Kristoffersen, U, Wiinberg, N, Kofoed, K, Andersen, O, Hesse, B, Petersen, C, Gerstoft, J & Kjær, A 2008, 'Coronary and peripheral endothelial function in HIV patients studied with positron emission tomography and flow-mediated dilation: relation to hypercholesterolemia.', European Journal of Nuclear Medicine and Molecular Imaging, vol. 35, no. 11, pp. 2049-2058. https://doi.org/10.1007/s00259-008-0846-6, https://doi.org/10.1007/s00259-008-0846-6

Lebech A-M, Kristoffersen US, Wiinberg N, Kofoed K, Andersen O, Hesse B et al. Coronary and peripheral endothelial function in HIV patients studied with positron emission tomography and flow-mediated dilation: relation to hypercholesterolemia. European Journal of Nuclear Medicine and Molecular Imaging. 2008;35(11):2049-2058. doi: 10.1007/s00259-008-0846-6, http://dx.doi.org/10.1007/s00259-008-0846-6

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title = "Coronary and peripheral endothelial function in HIV patients studied with positron emission tomography and flow-mediated dilation: relation to hypercholesterolemia.",

abstract = "BACKGROUND: The mechanisms underlying increased cardiovascular risk in HIV patients in antiretroviral therapy (ART) are not known. Our aim was to study the endothelial function of the coronary arteries by cardiac perfusion positron emission tomography (PET), in HIV patients with normal or high cholesterol levels. Flow mediated dilation (FMD) of the brachial artery and circulating endothelial markers were also assessed. METHODS AND RESULTS: HIV patients in ART with total cholesterol /= 6.5 mmol/L (254 mg/dL; n = 12) and healthy controls (n = 14) were included. (13)NH(3) perfusion PET, FMD, and measurement of plasma levels of E-Selectin, ICAM-1, VCAM-1, tPAI-1, and hs-CRP were performed. Baseline myocardial perfusion and the coronary flow reserve measured by PET (3.2 +/- 0.3, 3.2 +/- 0.3 and 3.0 +/- 0.3; ns) was similar in HIV patients with normal or high total cholesterol and controls. FMD did not differ between the groups and was 4.6 +/- 1.1%, 5.1 +/- 1.2%, and 4.6 +/- 0.8%, respectively. Increased levels of plasma E-Selectin, ICAM-1, tPAI-1, and hs-CRP were found in HIV patients when compared to controls (p < 0.05). E-Selectin and ICAM-1 levels were higher in HIV patients receiving protease inhibitors (PI) compared to those not receiving PI (p < 0.05). None of the measured endothelial biomarkers differed between the normal and high cholesterol HIV groups. CONCLUSIONS: In ART-treated HIV patients with a low overall cardiovascular risk, no sign of endothelial dysfunction was found not even in hypercholesterolemic patients. Also, the increased level of plasma endothelial markers found in HIV patients was not related to hypercholesterolemia.",

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year = "2008",

doi = "10.1007/s00259-008-0846-6",

language = "English",

volume = "35",

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TY - JOUR

T1 - Coronary and peripheral endothelial function in HIV patients studied with positron emission tomography and flow-mediated dilation: relation to hypercholesterolemia.

AU - Lebech, Anne-Mette

AU - Kristoffersen, Ulrik Sloth

AU - Wiinberg, Niels

AU - Kofoed, Kristian

AU - Andersen, Ove

AU - Hesse, Birger

AU - Petersen, Claus Leth

AU - Gerstoft, Jan

AU - Kjær, Andreas

AU - Lebech, Anne-Mette

AU - Kristoffersen, Ulrik

AU - Wiinberg, Niels

AU - Kofoed, Kristian

AU - Andersen, Ove

AU - Hesse, Birger

AU - Petersen, Claus

AU - Gerstoft, Jan

AU - Kjær, Andreas

PY - 2008

Y1 - 2008

N2 - BACKGROUND: The mechanisms underlying increased cardiovascular risk in HIV patients in antiretroviral therapy (ART) are not known. Our aim was to study the endothelial function of the coronary arteries by cardiac perfusion positron emission tomography (PET), in HIV patients with normal or high cholesterol levels. Flow mediated dilation (FMD) of the brachial artery and circulating endothelial markers were also assessed. METHODS AND RESULTS: HIV patients in ART with total cholesterol /= 6.5 mmol/L (254 mg/dL; n = 12) and healthy controls (n = 14) were included. (13)NH(3) perfusion PET, FMD, and measurement of plasma levels of E-Selectin, ICAM-1, VCAM-1, tPAI-1, and hs-CRP were performed. Baseline myocardial perfusion and the coronary flow reserve measured by PET (3.2 +/- 0.3, 3.2 +/- 0.3 and 3.0 +/- 0.3; ns) was similar in HIV patients with normal or high total cholesterol and controls. FMD did not differ between the groups and was 4.6 +/- 1.1%, 5.1 +/- 1.2%, and 4.6 +/- 0.8%, respectively. Increased levels of plasma E-Selectin, ICAM-1, tPAI-1, and hs-CRP were found in HIV patients when compared to controls (p < 0.05). E-Selectin and ICAM-1 levels were higher in HIV patients receiving protease inhibitors (PI) compared to those not receiving PI (p < 0.05). None of the measured endothelial biomarkers differed between the normal and high cholesterol HIV groups. CONCLUSIONS: In ART-treated HIV patients with a low overall cardiovascular risk, no sign of endothelial dysfunction was found not even in hypercholesterolemic patients. Also, the increased level of plasma endothelial markers found in HIV patients was not related to hypercholesterolemia.

AB - BACKGROUND: The mechanisms underlying increased cardiovascular risk in HIV patients in antiretroviral therapy (ART) are not known. Our aim was to study the endothelial function of the coronary arteries by cardiac perfusion positron emission tomography (PET), in HIV patients with normal or high cholesterol levels. Flow mediated dilation (FMD) of the brachial artery and circulating endothelial markers were also assessed. METHODS AND RESULTS: HIV patients in ART with total cholesterol /= 6.5 mmol/L (254 mg/dL; n = 12) and healthy controls (n = 14) were included. (13)NH(3) perfusion PET, FMD, and measurement of plasma levels of E-Selectin, ICAM-1, VCAM-1, tPAI-1, and hs-CRP were performed. Baseline myocardial perfusion and the coronary flow reserve measured by PET (3.2 +/- 0.3, 3.2 +/- 0.3 and 3.0 +/- 0.3; ns) was similar in HIV patients with normal or high total cholesterol and controls. FMD did not differ between the groups and was 4.6 +/- 1.1%, 5.1 +/- 1.2%, and 4.6 +/- 0.8%, respectively. Increased levels of plasma E-Selectin, ICAM-1, tPAI-1, and hs-CRP were found in HIV patients when compared to controls (p < 0.05). E-Selectin and ICAM-1 levels were higher in HIV patients receiving protease inhibitors (PI) compared to those not receiving PI (p < 0.05). None of the measured endothelial biomarkers differed between the normal and high cholesterol HIV groups. CONCLUSIONS: In ART-treated HIV patients with a low overall cardiovascular risk, no sign of endothelial dysfunction was found not even in hypercholesterolemic patients. Also, the increased level of plasma endothelial markers found in HIV patients was not related to hypercholesterolemia.

U2 - 10.1007/s00259-008-0846-6

DO - 10.1007/s00259-008-0846-6

M3 - Journal article

C2 - 18661131

SN - 1619-7070

VL - 35

SP - 2049

EP - 2058

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

IS - 11

ER -

Coronary and peripheral endothelial function in HIV patients studied with positron emission tomography and flow-mediated dilation: relation to hypercholesterolemia.

Abstract

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