TY - JOUR
T1 - Copeptin during rest and exercise in major depression
AU - Krogh, Jesper
AU - Gøtze, Jens Peter
AU - Jørgensen, Martin Balslev
AU - Kristensen, Lars Østergaard
AU - Kistorp, Caroline
AU - Nordentoft, Merete
PY - 2013/10
Y1 - 2013/10
N2 - Background: High vasopressin levels and a correlation between vasopressin and cortisol has been observed in patients with depression. The aim was to assess copeptin, the c-terminal of provasopressin, and the association between cortisol, adrenocorticotropic hormone (ACTH) and copeptin in patients with depression. Secondly, to examine the copeptin response to acute exercise and aerobic training. Methods: Copeptin, ACTH, and cortisol were measured in 111 patients with depression and 57 controls at rest. Copeptin was also measured during exercise. The depressed patients were subsequently rando Keywords: mized to an aerobic training intervention or an exercise control intervention. Results: The plasma level of copeptin in depressed subjects was 514 pgml (IQR 34-84) and 482 pgml (IQR 28-75) in healthy controls (p= 66). The association between copeptin and cortisol was02 (95% CI -44 to48; p=93) and the association between copeptin and ACTH was -06 (95% CI -17 taOS; p=27). All associations were independent of depression status (p= 15). Aerobic exercise training did not influence copeptin levels at rest (p= 09) or the response to acute exercise (p= 574). Copeptin decreased at rest in response to aerobic training in participants with high compliance to the exercise intervention (p= 04). Limitations: We did not measure plasma osmolality, which is a possible confounder in this study. Conclusions: Copeptin levels are not elevated or associated to ACTH or cortisol in depressed patients. Aerobic exercise training decreased copeptin levels in high attenders only. This study does not support a role of copeptin or vasopressin in depression.
AB - Background: High vasopressin levels and a correlation between vasopressin and cortisol has been observed in patients with depression. The aim was to assess copeptin, the c-terminal of provasopressin, and the association between cortisol, adrenocorticotropic hormone (ACTH) and copeptin in patients with depression. Secondly, to examine the copeptin response to acute exercise and aerobic training. Methods: Copeptin, ACTH, and cortisol were measured in 111 patients with depression and 57 controls at rest. Copeptin was also measured during exercise. The depressed patients were subsequently rando Keywords: mized to an aerobic training intervention or an exercise control intervention. Results: The plasma level of copeptin in depressed subjects was 514 pgml (IQR 34-84) and 482 pgml (IQR 28-75) in healthy controls (p= 66). The association between copeptin and cortisol was02 (95% CI -44 to48; p=93) and the association between copeptin and ACTH was -06 (95% CI -17 taOS; p=27). All associations were independent of depression status (p= 15). Aerobic exercise training did not influence copeptin levels at rest (p= 09) or the response to acute exercise (p= 574). Copeptin decreased at rest in response to aerobic training in participants with high compliance to the exercise intervention (p= 04). Limitations: We did not measure plasma osmolality, which is a possible confounder in this study. Conclusions: Copeptin levels are not elevated or associated to ACTH or cortisol in depressed patients. Aerobic exercise training decreased copeptin levels in high attenders only. This study does not support a role of copeptin or vasopressin in depression.
U2 - 10.1016/j.jad.2013.06.007
DO - 10.1016/j.jad.2013.06.007
M3 - Journal article
C2 - 23856279
SN - 0165-0327
VL - 151
SP - 284
EP - 290
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
IS - 1
ER -