Copenhagen uPAR prostate cancer (CuPCa) database: protocol and early results

Solvej Lippert; Kasper D Berg; Gunilla Høyer-Hansen; Ida K Lund; Peter Iversen; Ib J Christensen; Klaus Brasso; Martin A Røder

doi:10.2217/bmm.15.114

Copenhagen uPAR prostate cancer (CuPCa) database: protocol and early results

Solvej Lippert, Kasper D Berg, Gunilla Høyer-Hansen, Ida K Lund, Peter Iversen, Ib J Christensen, Klaus Brasso, Martin A Røder

8 Citations (Scopus)

Abstract

Urokinase plasminogen activator receptor (uPAR) plays a central role during cancer invasion by facilitating pericellular proteolysis. We initiated the prospective 'Copenhagen uPAR Prostate Cancer' study to investigate the significance of uPAR levels in prostate cancer (PCa) patients. Methods: Plasma samples and clinical data from patients with newly diagnosed PCa have been collected prospectively. The uPAR forms have been measured in plasma using time-resolved fluorescence immunoassays. Results: The level of intact uPAR(I-III) did not differ. Plasma uPAR(I-III) + uPAR(II-III) levels and uPAR(I) levels were significantly higher in hormone-naive and castrate-resistant patients compared with patients with localized disease (both: p < 0.0001). Conclusion: Our results show that cleaved uPAR forms are significantly increased in patients with advanced PCa.

Original language	English
Journal	Biomarkers in Medicine
Volume	10
Issue number	2
Pages (from-to)	209-16
Number of pages	8
ISSN	1752-0363
DOIs	https://doi.org/10.2217/bmm.15.114
Publication status	Published - Feb 2016

Keywords

Journal Article
Research Support, Non-U.S. Gov't

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/bmm.15.114

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title = "Copenhagen uPAR prostate cancer (CuPCa) database: protocol and early results",

abstract = "Urokinase plasminogen activator receptor (uPAR) plays a central role during cancer invasion by facilitating pericellular proteolysis. We initiated the prospective 'Copenhagen uPAR Prostate Cancer' study to investigate the significance of uPAR levels in prostate cancer (PCa) patients. Methods: Plasma samples and clinical data from patients with newly diagnosed PCa have been collected prospectively. The uPAR forms have been measured in plasma using time-resolved fluorescence immunoassays. Results: The level of intact uPAR(I-III) did not differ. Plasma uPAR(I-III) + uPAR(II-III) levels and uPAR(I) levels were significantly higher in hormone-naive and castrate-resistant patients compared with patients with localized disease (both: p < 0.0001). Conclusion: Our results show that cleaved uPAR forms are significantly increased in patients with advanced PCa.",

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author = "Solvej Lippert and Berg, {Kasper D} and Gunilla H{\o}yer-Hansen and Lund, {Ida K} and Peter Iversen and Christensen, {Ib J} and Klaus Brasso and R{\o}der, {Martin A}",

year = "2016",

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doi = "10.2217/bmm.15.114",

language = "English",

volume = "10",

pages = "209--16",

journal = "Biomarkers in Medicine",

issn = "1752-0363",

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T1 - Copenhagen uPAR prostate cancer (CuPCa) database

T2 - protocol and early results

AU - Lippert, Solvej

AU - Berg, Kasper D

AU - Høyer-Hansen, Gunilla

AU - Lund, Ida K

AU - Iversen, Peter

AU - Christensen, Ib J

AU - Brasso, Klaus

AU - Røder, Martin A

PY - 2016/2

Y1 - 2016/2

N2 - Urokinase plasminogen activator receptor (uPAR) plays a central role during cancer invasion by facilitating pericellular proteolysis. We initiated the prospective 'Copenhagen uPAR Prostate Cancer' study to investigate the significance of uPAR levels in prostate cancer (PCa) patients. Methods: Plasma samples and clinical data from patients with newly diagnosed PCa have been collected prospectively. The uPAR forms have been measured in plasma using time-resolved fluorescence immunoassays. Results: The level of intact uPAR(I-III) did not differ. Plasma uPAR(I-III) + uPAR(II-III) levels and uPAR(I) levels were significantly higher in hormone-naive and castrate-resistant patients compared with patients with localized disease (both: p < 0.0001). Conclusion: Our results show that cleaved uPAR forms are significantly increased in patients with advanced PCa.

AB - Urokinase plasminogen activator receptor (uPAR) plays a central role during cancer invasion by facilitating pericellular proteolysis. We initiated the prospective 'Copenhagen uPAR Prostate Cancer' study to investigate the significance of uPAR levels in prostate cancer (PCa) patients. Methods: Plasma samples and clinical data from patients with newly diagnosed PCa have been collected prospectively. The uPAR forms have been measured in plasma using time-resolved fluorescence immunoassays. Results: The level of intact uPAR(I-III) did not differ. Plasma uPAR(I-III) + uPAR(II-III) levels and uPAR(I) levels were significantly higher in hormone-naive and castrate-resistant patients compared with patients with localized disease (both: p < 0.0001). Conclusion: Our results show that cleaved uPAR forms are significantly increased in patients with advanced PCa.

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

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DO - 10.2217/bmm.15.114

M3 - Journal article

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SN - 1752-0363

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JO - Biomarkers in Medicine

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Copenhagen uPAR prostate cancer (CuPCa) database: protocol and early results

Abstract

Keywords

UN SDGs

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