Contribution of Italian clinical research for contrast media-induced nonrenal adverse drug reactions over the last three decades: A systematic review

Maurizio Sessa; Claudia Rossi; Annamaria Mascolo; Antonella Scafuro; Rosanna Ruggiero; Gabriella Di Mauro; Salvatore Cappabianca; Roberto Grassi; Liberata Sportiello; Concetta Rafaniello

doi:10.4103/jpp.JPP_92_18

Contribution of Italian clinical research for contrast media-induced nonrenal adverse drug reactions over the last three decades: A systematic review

Maurizio Sessa^*, Claudia Rossi, Annamaria Mascolo, Antonella Scafuro, Rosanna Ruggiero, Gabriella Di Mauro, Salvatore Cappabianca, Roberto Grassi, Liberata Sportiello, Concetta Rafaniello

^*Corresponding author for this work

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Abstract

The aim of this study was to investigate the scientific contribution of Italian clinical research for contrast media-induced nonrenal adverse drug reactions over the last three decades. Ovid Embase, Ovid MEDLINE, Web of Science, and Cochrane Methodology Register were used as data sources to identify Italian descriptive studies, observational studies, meta-analyses, and clinical trials assessing contrast media-induced nonrenal adverse drug reactions as a safety outcome. The population of interest was men and women exposed to a contrast medium. Between 1990 and 2017, 24 original articles investigating contrast-induced nonrenal adverse drug reactions were identified. The cohort study was the most representative study design (10/24; 41.7%). The 24 studies were conducted mainly as monocenter studies (14/24; 58.3%) and without receiving funding (17/24; 70.8%). Seventeen out of 24 studies provided a level of evidence ranging from III-2 (11/24; 45.8%) to IV (6/24; 25.0%) on a Merlin scale. In total, 14 of 24 (58.3%) studies were published in a scientific journal ranked in the first quartile of their subject area. The 24 original articles mainly focused on adverse drug reactions already observed during clinical trials (i.e., idiosyncratic systemic reactions). In conclusion, during the last three decades and a burst was not observed in the Italian clinical research investigating contrast-induced nonrenal adverse drug reactions. High-quality clinical research is needed especially for procedures to prevent the onset of the aforementioned events, to identify risk factors, to minimize the risk of their occurrence, and to optimize their related prognosis.

Original language	English
Journal	Journal of Pharmacology and Pharmacotherapeutics
Volume	9
Issue number	3
Pages (from-to)	131-146
Number of pages	16
ISSN	0976-500X
DOIs	https://doi.org/10.4103/jpp.JPP_92_18
Publication status	Published - 1 Jul 2018

Keywords

Adverse drug reactions
clinical research
contrast media
humans
Italy

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10.4103/jpp.JPP_92_18Licence: CC BY-NC

JPharmacolPharmacother93131-2838073_075300Final published version, 1 MBLicence: CC BY-NC

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Sessa, M., Rossi, C., Mascolo, A., Scafuro, A., Ruggiero, R., Di Mauro, G., Cappabianca, S., Grassi, R., Sportiello, L., & Rafaniello, C. (2018). Contribution of Italian clinical research for contrast media-induced nonrenal adverse drug reactions over the last three decades: A systematic review. Journal of Pharmacology and Pharmacotherapeutics, 9(3), 131-146. https://doi.org/10.4103/jpp.JPP_92_18

Contribution of Italian clinical research for contrast media-induced nonrenal adverse drug reactions over the last three decades: A systematic review. / Sessa, Maurizio; Rossi, Claudia; Mascolo, Annamaria et al.
In: Journal of Pharmacology and Pharmacotherapeutics, Vol. 9, No. 3, 01.07.2018, p. 131-146.

Research output: Contribution to journal › Review › peer-review

Sessa, M, Rossi, C, Mascolo, A, Scafuro, A, Ruggiero, R, Di Mauro, G, Cappabianca, S, Grassi, R, Sportiello, L & Rafaniello, C 2018, 'Contribution of Italian clinical research for contrast media-induced nonrenal adverse drug reactions over the last three decades: A systematic review', Journal of Pharmacology and Pharmacotherapeutics, vol. 9, no. 3, pp. 131-146. https://doi.org/10.4103/jpp.JPP_92_18

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abstract = "The aim of this study was to investigate the scientific contribution of Italian clinical research for contrast media-induced nonrenal adverse drug reactions over the last three decades. Ovid Embase, Ovid MEDLINE, Web of Science, and Cochrane Methodology Register were used as data sources to identify Italian descriptive studies, observational studies, meta-analyses, and clinical trials assessing contrast media-induced nonrenal adverse drug reactions as a safety outcome. The population of interest was men and women exposed to a contrast medium. Between 1990 and 2017, 24 original articles investigating contrast-induced nonrenal adverse drug reactions were identified. The cohort study was the most representative study design (10/24; 41.7%). The 24 studies were conducted mainly as monocenter studies (14/24; 58.3%) and without receiving funding (17/24; 70.8%). Seventeen out of 24 studies provided a level of evidence ranging from III-2 (11/24; 45.8%) to IV (6/24; 25.0%) on a Merlin scale. In total, 14 of 24 (58.3%) studies were published in a scientific journal ranked in the first quartile of their subject area. The 24 original articles mainly focused on adverse drug reactions already observed during clinical trials (i.e., idiosyncratic systemic reactions). In conclusion, during the last three decades and a burst was not observed in the Italian clinical research investigating contrast-induced nonrenal adverse drug reactions. High-quality clinical research is needed especially for procedures to prevent the onset of the aforementioned events, to identify risk factors, to minimize the risk of their occurrence, and to optimize their related prognosis.",

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AU - Mascolo, Annamaria

AU - Scafuro, Antonella

AU - Ruggiero, Rosanna

AU - Di Mauro, Gabriella

AU - Cappabianca, Salvatore

AU - Grassi, Roberto

AU - Sportiello, Liberata

AU - Rafaniello, Concetta

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AB - The aim of this study was to investigate the scientific contribution of Italian clinical research for contrast media-induced nonrenal adverse drug reactions over the last three decades. Ovid Embase, Ovid MEDLINE, Web of Science, and Cochrane Methodology Register were used as data sources to identify Italian descriptive studies, observational studies, meta-analyses, and clinical trials assessing contrast media-induced nonrenal adverse drug reactions as a safety outcome. The population of interest was men and women exposed to a contrast medium. Between 1990 and 2017, 24 original articles investigating contrast-induced nonrenal adverse drug reactions were identified. The cohort study was the most representative study design (10/24; 41.7%). The 24 studies were conducted mainly as monocenter studies (14/24; 58.3%) and without receiving funding (17/24; 70.8%). Seventeen out of 24 studies provided a level of evidence ranging from III-2 (11/24; 45.8%) to IV (6/24; 25.0%) on a Merlin scale. In total, 14 of 24 (58.3%) studies were published in a scientific journal ranked in the first quartile of their subject area. The 24 original articles mainly focused on adverse drug reactions already observed during clinical trials (i.e., idiosyncratic systemic reactions). In conclusion, during the last three decades and a burst was not observed in the Italian clinical research investigating contrast-induced nonrenal adverse drug reactions. High-quality clinical research is needed especially for procedures to prevent the onset of the aforementioned events, to identify risk factors, to minimize the risk of their occurrence, and to optimize their related prognosis.

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Contribution of Italian clinical research for contrast media-induced nonrenal adverse drug reactions over the last three decades: A systematic review

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