Contribution of animal models to the understanding of the metabolic syndrome: a systematic overview

O. Varga; M. Harangi; A.S. Olsson; Axel Jacob Kornerup Hansen

doi:10.1111/j.1467-789x.2009.00667.x

Contribution of animal models to the understanding of the metabolic syndrome: a systematic overview

O. Varga, M. Harangi, A.S. Olsson, Axel Jacob Kornerup Hansen

48 Citations (Scopus)

Abstract

The metabolic syndrome (MetS) is one of the most important challenges to public health and biomedical research. Animal models of MetS, such as leptin-deficient obese mice, obese spontaneously hypertensive rats, JCR: LA-cp rats and the Ossabaw and Göttingen minipigs, have contributed to our understanding of the pathophysiological basis and the development of novel therapies. For a complex disease syndrome, no animal model can be expected to serve all needs of research. Although each animal model has limitations and strengths, used together in a complementary fashion, they are essential for research on the MetS and for rapid progress in understanding the aetiology and pathogenesis towards a cure. The purpose of this review is to assess how current animal models contributed to our knowledge of the human MetS, and to systematically evaluate the strengths and weaknesses of the currently available 78 animal models from 11 species.

Original language	English
Journal	Obesity Reviews
Volume	11
Issue number	11
Pages (from-to)	792-807
Number of pages	16
ISSN	1467-7881
DOIs	https://doi.org/10.1111/j.1467-789x.2009.00667.x
Publication status	Published - Nov 2010

Keywords

.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1467-789x.2009.00667.x

Cite this

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Contribution of animal models to the understanding of the metabolic syndrome: a systematic overview

Abstract

Keywords

UN SDGs

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