Continuous Flow Nucleophilic Aromatic Substitution with Dimethylamine Generated in Situ by Decomposition of DMF

Trine P Petersen; Anders Foller Larsen; Andreas Ritzén; Trond Ulven

doi:10.1021/jo400390t

Continuous Flow Nucleophilic Aromatic Substitution with Dimethylamine Generated in Situ by Decomposition of DMF

Trine P Petersen, Anders Foller Larsen, Andreas Ritzén, Trond Ulven

33 Citations (Scopus)

Abstract

A safe, practical, and scalable continuous flow protocol for the in situ generation of dimethylamine from DMF followed by nucleophilic aromatic substitution of a broad range of aromatic and heteroaromatic halides is reported.

Original language	English
Journal	Journal of Organic Chemistry
Volume	78
Issue number	8
Pages (from-to)	4190-4195
Number of pages	6
ISSN	0022-3263
DOIs	https://doi.org/10.1021/jo400390t
Publication status	Published - 19 Apr 2013

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title = "Continuous Flow Nucleophilic Aromatic Substitution with Dimethylamine Generated in Situ by Decomposition of DMF",

abstract = "A safe, practical, and scalable continuous flow protocol for the in situ generation of dimethylamine from DMF followed by nucleophilic aromatic substitution of a broad range of aromatic and heteroaromatic halides is reported.",

author = "Petersen, {Trine P} and Larsen, {Anders Foller} and Andreas Ritz{\'e}n and Trond Ulven",

year = "2013",

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doi = "10.1021/jo400390t",

language = "English",

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T1 - Continuous Flow Nucleophilic Aromatic Substitution with Dimethylamine Generated in Situ by Decomposition of DMF

AU - Petersen, Trine P

AU - Larsen, Anders Foller

AU - Ritzén, Andreas

AU - Ulven, Trond

PY - 2013/4/19

Y1 - 2013/4/19

N2 - A safe, practical, and scalable continuous flow protocol for the in situ generation of dimethylamine from DMF followed by nucleophilic aromatic substitution of a broad range of aromatic and heteroaromatic halides is reported.

AB - A safe, practical, and scalable continuous flow protocol for the in situ generation of dimethylamine from DMF followed by nucleophilic aromatic substitution of a broad range of aromatic and heteroaromatic halides is reported.

U2 - 10.1021/jo400390t

DO - 10.1021/jo400390t

M3 - Journal article

SN - 0022-3263

VL - 78

SP - 4190

EP - 4195

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 8

ER -

Continuous Flow Nucleophilic Aromatic Substitution with Dimethylamine Generated in Situ by Decomposition of DMF

Abstract

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