TY - JOUR
T1 - Continuation of growth hormone therapy versus placebo in transition-phase patients with growth hormone deficiency
T2 - impact on body composition, insulin sensitivity, and thyroid function
AU - Jørgensen, Jens
AU - Nørrelund, Helene
AU - Vahl, Nina
AU - Juul, Anders
AU - Skakkebaek, Niels E
AU - Christiansen, Jens Sandahl
PY - 2002
Y1 - 2002
N2 - In a placebo-controlled, parallel study of 18 patients with a mean age of 20 years who had confirmed growth hormone (GH) deficiency, we evaluated body composition, insulin sensitivity, and glucose turnover at baseline (when all were receiving GH replacement); after 12 months of continued GH therapy or placebo; and after a 12-month open phase of GH therapy. In the placebo group, insulin sensitivity and fat mass increased and lipid oxidation decreased, whereas glucose oxidation increased (p
AB - In a placebo-controlled, parallel study of 18 patients with a mean age of 20 years who had confirmed growth hormone (GH) deficiency, we evaluated body composition, insulin sensitivity, and glucose turnover at baseline (when all were receiving GH replacement); after 12 months of continued GH therapy or placebo; and after a 12-month open phase of GH therapy. In the placebo group, insulin sensitivity and fat mass increased and lipid oxidation decreased, whereas glucose oxidation increased (p
M3 - Journal article
SN - 0334-018X
VL - 15 Suppl 5
SP - 1355
EP - 1360
JO - Journal of Pediatric Endocrinology and Metabolism
JF - Journal of Pediatric Endocrinology and Metabolism
ER -