Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition

Mireia Obon-Santacana; Leila Lujan-Barroso; Heinz Freisling; Sabine Naudin; Marie-Christine Boutron-Ruault; Francesca Romana Mancini; Vinciane Rebours; Tilman Kuehn; Verena Katzke; Heiner Boeing; Anne Tjønneland; Anja Olsen; Kim Overvad; Cristina Lasheras; Miguel Rodriguez-Barranco; Pilar Amiano; Carmen Santiuste; Eva Ardanaz; Kay-Thee Khaw; Nicholas J. Wareham; Julie A. Schmidt; Dagfinn Aune; Antonia Trichopoulou; Paschalis Thriskos; Eleni Peppa; Giovanna Masala; Sara Grioni; Rosario Tumino; Salvatore Panico; Bas Bueno-de-Mesquita; Veronica Sciannameo; Roel Vermeulen; Emily Sonestedt; Malin Sund; Elisabete Weiderpass; Guri Skeie; Carlos A. Gonzalez; Elio Riboli; Eric J. Duell

doi:10.1002/ijc.32415

Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition

Mireia Obon-Santacana, Leila Lujan-Barroso, Heinz Freisling, Sabine Naudin, Marie-Christine Boutron-Ruault, Francesca Romana Mancini, Vinciane Rebours, Tilman Kuehn, Verena Katzke, Heiner Boeing, Anne Tjønneland, Anja Olsen, Kim Overvad, Cristina Lasheras, Miguel Rodriguez-Barranco, Pilar Amiano, Carmen Santiuste, Eva Ardanaz, Kay-Thee Khaw, Nicholas J. WarehamJulie A. Schmidt, Dagfinn Aune, Antonia Trichopoulou, Paschalis Thriskos, Eleni Peppa, Giovanna Masala, Sara Grioni, Rosario Tumino, Salvatore Panico, Bas Bueno-de-Mesquita, Veronica Sciannameo, Roel Vermeulen, Emily Sonestedt, Malin Sund, Elisabete Weiderpass, Guri Skeie, Carlos A. Gonzalez, Elio Riboli, Eric J. Duell

Section of Environmental Health

5 Citations (Scopus)

Abstract

Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72–1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.

Original language	English
Journal	International Journal of Cancer
Volume	146
Issue number	1
Pages (from-to)	76-84
Number of pages	9
ISSN	0020-7136
DOIs	https://doi.org/10.1002/ijc.32415
Publication status	Published - 1 Jan 2020

Keywords

pancreatic cancer
nuts
seeds
diet
intake
EPIC
prospective cohort study

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ijc.32415

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Obon-Santacana, M., Lujan-Barroso, L., Freisling, H., Naudin, S., Boutron-Ruault, M-C., Mancini, F. R., Rebours, V., Kuehn, T., Katzke, V., Boeing, H., Tjønneland, A., Olsen, A., Overvad, K., Lasheras, C., Rodriguez-Barranco, M., Amiano, P., Santiuste, C., Ardanaz, E., Khaw, K-T., ... Duell, E. J. (2020). Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer, 146(1), 76-84. https://doi.org/10.1002/ijc.32415

Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition. / Obon-Santacana, Mireia; Lujan-Barroso, Leila; Freisling, Heinz et al.

In: International Journal of Cancer, Vol. 146, No. 1, 01.01.2020, p. 76-84.

Research output: Contribution to journal › Journal article › Research › peer-review

Obon-Santacana, M, Lujan-Barroso, L, Freisling, H, Naudin, S, Boutron-Ruault, M-C, Mancini, FR, Rebours, V, Kuehn, T, Katzke, V, Boeing, H, Tjønneland, A, Olsen, A, Overvad, K, Lasheras, C, Rodriguez-Barranco, M, Amiano, P, Santiuste, C, Ardanaz, E, Khaw, K-T, Wareham, NJ, Schmidt, JA, Aune, D, Trichopoulou, A, Thriskos, P, Peppa, E, Masala, G, Grioni, S, Tumino, R, Panico, S, Bueno-de-Mesquita, B, Sciannameo, V, Vermeulen, R, Sonestedt, E, Sund, M, Weiderpass, E, Skeie, G, Gonzalez, CA, Riboli, E & Duell, EJ 2020, 'Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition', International Journal of Cancer, vol. 146, no. 1, pp. 76-84. https://doi.org/10.1002/ijc.32415

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title = "Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition",

abstract = "Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72–1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.",

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author = "Mireia Obon-Santacana and Leila Lujan-Barroso and Heinz Freisling and Sabine Naudin and Marie-Christine Boutron-Ruault and Mancini, {Francesca Romana} and Vinciane Rebours and Tilman Kuehn and Verena Katzke and Heiner Boeing and Anne Tj{\o}nneland and Anja Olsen and Kim Overvad and Cristina Lasheras and Miguel Rodriguez-Barranco and Pilar Amiano and Carmen Santiuste and Eva Ardanaz and Kay-Thee Khaw and Wareham, {Nicholas J.} and Schmidt, {Julie A.} and Dagfinn Aune and Antonia Trichopoulou and Paschalis Thriskos and Eleni Peppa and Giovanna Masala and Sara Grioni and Rosario Tumino and Salvatore Panico and Bas Bueno-de-Mesquita and Veronica Sciannameo and Roel Vermeulen and Emily Sonestedt and Malin Sund and Elisabete Weiderpass and Guri Skeie and Gonzalez, {Carlos A.} and Elio Riboli and Duell, {Eric J.}",

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AU - Obon-Santacana, Mireia

AU - Lujan-Barroso, Leila

AU - Freisling, Heinz

AU - Naudin, Sabine

AU - Boutron-Ruault, Marie-Christine

AU - Mancini, Francesca Romana

AU - Rebours, Vinciane

AU - Kuehn, Tilman

AU - Katzke, Verena

AU - Boeing, Heiner

AU - Tjønneland, Anne

AU - Olsen, Anja

AU - Overvad, Kim

AU - Lasheras, Cristina

AU - Rodriguez-Barranco, Miguel

AU - Amiano, Pilar

AU - Santiuste, Carmen

AU - Ardanaz, Eva

AU - Khaw, Kay-Thee

AU - Wareham, Nicholas J.

AU - Schmidt, Julie A.

AU - Aune, Dagfinn

AU - Trichopoulou, Antonia

AU - Thriskos, Paschalis

AU - Peppa, Eleni

AU - Masala, Giovanna

AU - Grioni, Sara

AU - Tumino, Rosario

AU - Panico, Salvatore

AU - Bueno-de-Mesquita, Bas

AU - Sciannameo, Veronica

AU - Vermeulen, Roel

AU - Sonestedt, Emily

AU - Sund, Malin

AU - Weiderpass, Elisabete

AU - Skeie, Guri

AU - Gonzalez, Carlos A.

AU - Riboli, Elio

AU - Duell, Eric J.

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72–1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.

AB - Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72–1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.

KW - pancreatic cancer

KW - nuts

KW - seeds

KW - diet

KW - intake

KW - EPIC

KW - prospective cohort study

U2 - 10.1002/ijc.32415

DO - 10.1002/ijc.32415

M3 - Journal article

C2 - 31107546

SN - 0020-7136

VL - 146

SP - 76

EP - 84

JO - Radiation Oncology Investigations

JF - Radiation Oncology Investigations

IS - 1

ER -

Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition

Abstract

Keywords

UN SDGs

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