Constitutive expression of inducible nitric oxide synthase in the normal human colonic epithelium

TY - JOUR

T1 - Constitutive expression of inducible nitric oxide synthase in the normal human colonic epithelium

AU - Perner, A

AU - Andresen, Lars

AU - Normark, M

AU - Rask-Madsen, J

PY - 2002

Y1 - 2002

N2 - Inducible nitric oxide synthase (iNOS) in the human colon is considered expressed only in inflammatory states such as ulcerative or collagenous colitis. As subtle iNOS labelling was previously observed in some colonic mucosal biopsies from a heterogeneous group of controls with non-inflamed bowel, we studied whether bowel preparation with bisacodyl or polyethylene glycol prior to sigmoidoscopy might induce iNOS expression.

AB - Inducible nitric oxide synthase (iNOS) in the human colon is considered expressed only in inflammatory states such as ulcerative or collagenous colitis. As subtle iNOS labelling was previously observed in some colonic mucosal biopsies from a heterogeneous group of controls with non-inflamed bowel, we studied whether bowel preparation with bisacodyl or polyethylene glycol prior to sigmoidoscopy might induce iNOS expression.

KW - Adult

KW - Bisacodyl

KW - Blotting, Western

KW - Cathartics

KW - Colon

KW - Humans

KW - Immunohistochemistry

KW - Intestinal Mucosa

KW - Male

KW - Nitric Oxide Synthase

KW - Nitric Oxide Synthase Type II

KW - Polyethylene Glycols

M3 - Journal article

C2 - 12229970

SN - 0036-5521

VL - 37

SP - 944

EP - 948

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

IS - 8

ER -