Conditional beta1-integrin gene deletion in neural crest cells causes severe developmental alterations of the peripheral nervous system.

TY - JOUR

T1 - Conditional beta1-integrin gene deletion in neural crest cells causes severe developmental alterations of the peripheral nervous system.

AU - Pietri, Thomas

AU - Eder, Olivier

AU - Breau, Marie Anne

AU - Topilko, Piotr

AU - Blanche, Martine

AU - Brakebusch, Cord

AU - Fässler, Reinhard

AU - Thiery, Jean-Paul

AU - Dufour, Sylvie

N1 - Keywords: Animals; Antigens, CD29; Gene Deletion; Mice; Microscopy, Electron; Mutation; Neural Crest; Peripheral Nervous System; Sciatic Nerve

PY - 2004

Y1 - 2004

N2 - Integrins are transmembrane receptors that are known to interact with the extracellular matrix and to be required for migration, proliferation, differentiation and apoptosis. We have generated mice with a neural crest cell-specific deletion of the beta1-integrin gene to analyse the role of beta1-integrins in neural crest cell migration and differentiation. This targeted mutation caused death within a month of birth. The loss of beta1-integrins from the embryo delayed the migration of Schwann cells along axons and induced multiple defects in spinal nerve arborisation and morphology. There was an almost complete absence of Schwann cells and sensory axon segregation and defective maturation in neuromuscular synaptogenesis. Thus, beta1-integrins are important for the control of embryonic and postnatal peripheral nervous system development.

AB - Integrins are transmembrane receptors that are known to interact with the extracellular matrix and to be required for migration, proliferation, differentiation and apoptosis. We have generated mice with a neural crest cell-specific deletion of the beta1-integrin gene to analyse the role of beta1-integrins in neural crest cell migration and differentiation. This targeted mutation caused death within a month of birth. The loss of beta1-integrins from the embryo delayed the migration of Schwann cells along axons and induced multiple defects in spinal nerve arborisation and morphology. There was an almost complete absence of Schwann cells and sensory axon segregation and defective maturation in neuromuscular synaptogenesis. Thus, beta1-integrins are important for the control of embryonic and postnatal peripheral nervous system development.

U2 - 10.1242/dev.01264

DO - 10.1242/dev.01264

M3 - Journal article

C2 - 15253938

SN - 0950-1991

VL - 131

SP - 3871

EP - 3883

JO - Development

JF - Development

IS - 16

ER -