Concise synthesis of new bridged-nicotine analogues

François Crestey; Geert  Hooyberghs; Jesper Langgaard Kristensen

doi:10.1016/j.tet.2011.12.029

Concise synthesis of new bridged-nicotine analogues

François Crestey, Geert Hooyberghs, Jesper Langgaard Kristensen

7 Citations (Scopus)

Abstract

This study describes a very efficient strategy for the synthesis of two new bridged-nicotine analogues. Starting from either 4- or 3-chloropyridine the desired tricyclic ring systems are accessed in just three steps in 23% and 40% overall yield, respectively.

Original language	English
Journal	Tetrahedron
Volume	68
Issue number	5
Pages (from-to)	1417-1421
ISSN	0040-4020
DOIs	https://doi.org/10.1016/j.tet.2011.12.029
Publication status	Published - 4 Feb 2012

Keywords

Former Faculty of Pharmaceutical Sciences

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10.1016/j.tet.2011.12.029

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title = "Concise synthesis of new bridged-nicotine analogues",

abstract = "This study describes a very efficient strategy for the synthesis of two new bridged-nicotine analogues. Starting from either 4- or 3-chloropyridine the desired tricyclic ring systems are accessed in just three steps in 23% and 40% overall yield, respectively.",

keywords = "Former Faculty of Pharmaceutical Sciences",

author = "Fran{\c c}ois Crestey and Geert Hooyberghs and Kristensen, {Jesper Langgaard}",

note = "Keywords: Pyridine metallation; Bridged-nicotine analogue; Suzukie-Miyaura cross-coupling reaction; Nicotinic acetylcholine receptor; Intramolecular reductive amination",

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AU - Crestey, François

AU - Hooyberghs, Geert

AU - Kristensen, Jesper Langgaard

N1 - Keywords: Pyridine metallation; Bridged-nicotine analogue; Suzukie-Miyaura cross-coupling reaction; Nicotinic acetylcholine receptor; Intramolecular reductive amination

PY - 2012/2/4

Y1 - 2012/2/4

N2 - This study describes a very efficient strategy for the synthesis of two new bridged-nicotine analogues. Starting from either 4- or 3-chloropyridine the desired tricyclic ring systems are accessed in just three steps in 23% and 40% overall yield, respectively.

AB - This study describes a very efficient strategy for the synthesis of two new bridged-nicotine analogues. Starting from either 4- or 3-chloropyridine the desired tricyclic ring systems are accessed in just three steps in 23% and 40% overall yield, respectively.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1016/j.tet.2011.12.029

DO - 10.1016/j.tet.2011.12.029

M3 - Journal article

SN - 0040-4020

VL - 68

SP - 1417

EP - 1421

JO - Tetrahedron

JF - Tetrahedron

IS - 5

ER -

Concise synthesis of new bridged-nicotine analogues

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