Concentration compared with total urinary excretion of 11,17-DOA in cynomolgus monkey urine

Jann Hau, F Royo

    Abstract

    Strees sensitive molecules exhibit great variation in concentration in the circulation and it may often be advantageous to quantify these in urine or feces rather than in serum or plasma. We advocate that all urine-or feces-should be collected, and that excretion of stress sensitive molecules should be expressed as amounts excreted per time unit per kg body-weight, rather than being expressed as concentrations in samples. Urine and feces excretion varies significantly within and between animals over time, which may render simple concentration measures of molecules of little biological relevance.
    Original languageEnglish
    JournalJournal of Medical Primatology
    Volume38
    Issue number4
    Pages (from-to)290-1
    Number of pages1
    ISSN0047-2565
    DOIs
    Publication statusPublished - 2008

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