Concanavalin-A-activated suppressor cells in patients with juvenile rheumatoid arthritis

L B Astrup; N Morling; L P Ryder; J Friis; F K Pedersen; A Svejgaard

Concanavalin-A-activated suppressor cells in patients with juvenile rheumatoid arthritis

L B Astrup, N Morling, L P Ryder, J Friis, F K Pedersen, A Svejgaard

7 Citations (Scopus)

Abstract

Concanavalin-A-induced suppressor cell activity was investigated in 63 patients with a definite diagnosis of juvenile rheumatoid arthritis. Peripheral blood lymphoid cells from these patients did not have the same ability as cells from normal individuals to suppress the proliferative response of autologous cells, responding to phytohaemaglutinin, Candida albicans antigen, or allogeneic cells. No correlation was found between suppressor activity, disease activity, or number of joints involved. Nor was there any significant association between decreased suppressor cell activity and HLA-A, -B, -C, -D antigens, although there was a tendency towards association between decreased suppressor cell activity and HLA-B27.

Original language	English
Journal	Scandinavian Journal of Immunology
Volume	16
Issue number	5
Pages (from-to)	361-7
Number of pages	6
ISSN	0300-9475
Publication status	Published - 1982
Externally published	Yes

Cite this

@article{a3316a70328811df8ed1000ea68e967b,

title = "Concanavalin-A-activated suppressor cells in patients with juvenile rheumatoid arthritis",

abstract = "Concanavalin-A-induced suppressor cell activity was investigated in 63 patients with a definite diagnosis of juvenile rheumatoid arthritis. Peripheral blood lymphoid cells from these patients did not have the same ability as cells from normal individuals to suppress the proliferative response of autologous cells, responding to phytohaemaglutinin, Candida albicans antigen, or allogeneic cells. No correlation was found between suppressor activity, disease activity, or number of joints involved. Nor was there any significant association between decreased suppressor cell activity and HLA-A, -B, -C, -D antigens, although there was a tendency towards association between decreased suppressor cell activity and HLA-B27.",

author = "Astrup, {L B} and N Morling and Ryder, {L P} and J Friis and Pedersen, {F K} and A Svejgaard",

note = "Keywords: Adolescent; Adult; Arthritis, Juvenile Rheumatoid; Child; Child, Preschool; Concanavalin A; Dose-Response Relationship, Immunologic; Female; Genes, MHC Class II; HLA Antigens; HLA-B Antigens; HLA-C Antigens; HLA-DR Antigens; Humans; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Male; Middle Aged; Phytohemagglutinins; T-Lymphocytes, Regulatory",

year = "1982",

language = "English",

volume = "16",

pages = "361--7",

journal = "Scandinavian Journal of Immunology, Supplement",

issn = "0301-6323",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Concanavalin-A-activated suppressor cells in patients with juvenile rheumatoid arthritis

AU - Astrup, L B

AU - Morling, N

AU - Ryder, L P

AU - Friis, J

AU - Pedersen, F K

AU - Svejgaard, A

N1 - Keywords: Adolescent; Adult; Arthritis, Juvenile Rheumatoid; Child; Child, Preschool; Concanavalin A; Dose-Response Relationship, Immunologic; Female; Genes, MHC Class II; HLA Antigens; HLA-B Antigens; HLA-C Antigens; HLA-DR Antigens; Humans; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Male; Middle Aged; Phytohemagglutinins; T-Lymphocytes, Regulatory

PY - 1982

Y1 - 1982

N2 - Concanavalin-A-induced suppressor cell activity was investigated in 63 patients with a definite diagnosis of juvenile rheumatoid arthritis. Peripheral blood lymphoid cells from these patients did not have the same ability as cells from normal individuals to suppress the proliferative response of autologous cells, responding to phytohaemaglutinin, Candida albicans antigen, or allogeneic cells. No correlation was found between suppressor activity, disease activity, or number of joints involved. Nor was there any significant association between decreased suppressor cell activity and HLA-A, -B, -C, -D antigens, although there was a tendency towards association between decreased suppressor cell activity and HLA-B27.

AB - Concanavalin-A-induced suppressor cell activity was investigated in 63 patients with a definite diagnosis of juvenile rheumatoid arthritis. Peripheral blood lymphoid cells from these patients did not have the same ability as cells from normal individuals to suppress the proliferative response of autologous cells, responding to phytohaemaglutinin, Candida albicans antigen, or allogeneic cells. No correlation was found between suppressor activity, disease activity, or number of joints involved. Nor was there any significant association between decreased suppressor cell activity and HLA-A, -B, -C, -D antigens, although there was a tendency towards association between decreased suppressor cell activity and HLA-B27.

M3 - Journal article

C2 - 6217541

SN - 0301-6323

VL - 16

SP - 361

EP - 367

JO - Scandinavian Journal of Immunology, Supplement

JF - Scandinavian Journal of Immunology, Supplement

IS - 5

ER -

Concanavalin-A-activated suppressor cells in patients with juvenile rheumatoid arthritis

Abstract

Fingerprint

Cite this