Competing to destroy: a fight between two RNA-degradation systems

Genevieve Thon

doi:10.1038/nsmb1008-1001

Competing to destroy: a fight between two RNA-degradation systems

Functional Genomics

Abstract

The Argonaute-1 (Ago1) protein bound to small interfering RNAs (siRNAs) directs heterochromatin formation in fission yeast. A high-throughput sequencing approach reveals that the composition of the Ago1-bound siRNA population is sensitive to the noncanonical poly(A) polymerase Cid14, indicating that the RNA-interference and Cid14-TRAMP RNA-degradation pathways compete for substrates in fission yeast.

Original language	English
Journal	Nature Structural and Molecular Biology
Volume	15
Issue number	10
Pages (from-to)	1001-2
Number of pages	2
ISSN	1545-9993
DOIs	https://doi.org/10.1038/nsmb1008-1001
Publication status	Published - 2008

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title = "Competing to destroy: a fight between two RNA-degradation systems",

abstract = "The Argonaute-1 (Ago1) protein bound to small interfering RNAs (siRNAs) directs heterochromatin formation in fission yeast. A high-throughput sequencing approach reveals that the composition of the Ago1-bound siRNA population is sensitive to the noncanonical poly(A) polymerase Cid14, indicating that the RNA-interference and Cid14-TRAMP RNA-degradation pathways compete for substrates in fission yeast.",

author = "Genevieve Thon",

note = "KEYWORDS: Protein Binding; RNA Stability; RNA, Small Interfering; Schizosaccharomyces",

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AB - The Argonaute-1 (Ago1) protein bound to small interfering RNAs (siRNAs) directs heterochromatin formation in fission yeast. A high-throughput sequencing approach reveals that the composition of the Ago1-bound siRNA population is sensitive to the noncanonical poly(A) polymerase Cid14, indicating that the RNA-interference and Cid14-TRAMP RNA-degradation pathways compete for substrates in fission yeast.

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DO - 10.1038/nsmb1008-1001

M3 - Journal article

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SP - 1001

EP - 1002

JO - Nature Structural and Molecular Biology

JF - Nature Structural and Molecular Biology

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Competing to destroy: a fight between two RNA-degradation systems

Abstract

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