Comparison of the manual and computer-aided techniques for evaluation of wrist synovitis using dynamic contrast-enhanced MRI on a dedicated scanner

Mikael Boesen; Olga Kubassova; Massimiliano Parodi; Henning Bliddal; Stefania Innocenti; Giacomo Garlaschi; Marco A Cimmino

doi:10.1016/j.ejrad.2010.09.041

Comparison of the manual and computer-aided techniques for evaluation of wrist synovitis using dynamic contrast-enhanced MRI on a dedicated scanner

Mikael Boesen, Olga Kubassova, Massimiliano Parodi, Henning Bliddal, Stefania Innocenti, Giacomo Garlaschi, Marco A Cimmino

22 Citations (Scopus)

Abstract

Objective: Traditional methods for assessment of synovial inflammation in rheumatoid arthritis such as clinical examination, immunohistology of bioptic samples, scintigraphy, and radiography have several limitations, including lack of sensitivity, need of invasive techniques, and administration of radioactive material. MRI lacks on standardisation and the data are often analysed using laborious, relatively rigid scoring methods. Materials and methods: This study introduces a standardized computer-aided method for quantitative analysis of MRI of the wrist on a dedicated scanner. Assessment of the synovial inflammation was performed using a semi-automated model-based method in conjunction with patient motion reduction algorithms. Further, the new method was compared with the traditional user-dependent ROI-based technique. Results: The computer-aided technique generated robust and reproducible results. Application of motion reduction algorithms allowed for significant improvements of the signal to noise ratio, which is especially important in the datasets acquired with low-field scanners. Conclusion: The use of the computer software can be beneficial for diagnostic decision in cross sectional as well as longitudinal MRI examinations of the wrist in rheumatoid arthritis.

Original language	English
Journal	European Journal of Radiology
Volume	77
Issue number	2
Pages (from-to)	202-6
Number of pages	5
ISSN	0720-048X
DOIs	https://doi.org/10.1016/j.ejrad.2010.09.041
Publication status	Published - 2011

Access to Document

10.1016/j.ejrad.2010.09.041

Cite this

@article{35daf142fd2c4449a56e0531ae9ef9a2,

title = "Comparison of the manual and computer-aided techniques for evaluation of wrist synovitis using dynamic contrast-enhanced MRI on a dedicated scanner",

abstract = "Objective: Traditional methods for assessment of synovial inflammation in rheumatoid arthritis such as clinical examination, immunohistology of bioptic samples, scintigraphy, and radiography have several limitations, including lack of sensitivity, need of invasive techniques, and administration of radioactive material. MRI lacks on standardisation and the data are often analysed using laborious, relatively rigid scoring methods. Materials and methods: This study introduces a standardized computer-aided method for quantitative analysis of MRI of the wrist on a dedicated scanner. Assessment of the synovial inflammation was performed using a semi-automated model-based method in conjunction with patient motion reduction algorithms. Further, the new method was compared with the traditional user-dependent ROI-based technique. Results: The computer-aided technique generated robust and reproducible results. Application of motion reduction algorithms allowed for significant improvements of the signal to noise ratio, which is especially important in the datasets acquired with low-field scanners. Conclusion: The use of the computer software can be beneficial for diagnostic decision in cross sectional as well as longitudinal MRI examinations of the wrist in rheumatoid arthritis.",

author = "Mikael Boesen and Olga Kubassova and Massimiliano Parodi and Henning Bliddal and Stefania Innocenti and Giacomo Garlaschi and Cimmino, {Marco A}",

year = "2011",

doi = "10.1016/j.ejrad.2010.09.041",

language = "English",

volume = "77",

pages = "202--6",

journal = "European Journal of Radiology",

issn = "0720-048X",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Comparison of the manual and computer-aided techniques for evaluation of wrist synovitis using dynamic contrast-enhanced MRI on a dedicated scanner

AU - Boesen, Mikael

AU - Kubassova, Olga

AU - Parodi, Massimiliano

AU - Bliddal, Henning

AU - Innocenti, Stefania

AU - Garlaschi, Giacomo

AU - Cimmino, Marco A

PY - 2011

Y1 - 2011

N2 - Objective: Traditional methods for assessment of synovial inflammation in rheumatoid arthritis such as clinical examination, immunohistology of bioptic samples, scintigraphy, and radiography have several limitations, including lack of sensitivity, need of invasive techniques, and administration of radioactive material. MRI lacks on standardisation and the data are often analysed using laborious, relatively rigid scoring methods. Materials and methods: This study introduces a standardized computer-aided method for quantitative analysis of MRI of the wrist on a dedicated scanner. Assessment of the synovial inflammation was performed using a semi-automated model-based method in conjunction with patient motion reduction algorithms. Further, the new method was compared with the traditional user-dependent ROI-based technique. Results: The computer-aided technique generated robust and reproducible results. Application of motion reduction algorithms allowed for significant improvements of the signal to noise ratio, which is especially important in the datasets acquired with low-field scanners. Conclusion: The use of the computer software can be beneficial for diagnostic decision in cross sectional as well as longitudinal MRI examinations of the wrist in rheumatoid arthritis.

AB - Objective: Traditional methods for assessment of synovial inflammation in rheumatoid arthritis such as clinical examination, immunohistology of bioptic samples, scintigraphy, and radiography have several limitations, including lack of sensitivity, need of invasive techniques, and administration of radioactive material. MRI lacks on standardisation and the data are often analysed using laborious, relatively rigid scoring methods. Materials and methods: This study introduces a standardized computer-aided method for quantitative analysis of MRI of the wrist on a dedicated scanner. Assessment of the synovial inflammation was performed using a semi-automated model-based method in conjunction with patient motion reduction algorithms. Further, the new method was compared with the traditional user-dependent ROI-based technique. Results: The computer-aided technique generated robust and reproducible results. Application of motion reduction algorithms allowed for significant improvements of the signal to noise ratio, which is especially important in the datasets acquired with low-field scanners. Conclusion: The use of the computer software can be beneficial for diagnostic decision in cross sectional as well as longitudinal MRI examinations of the wrist in rheumatoid arthritis.

U2 - 10.1016/j.ejrad.2010.09.041

DO - 10.1016/j.ejrad.2010.09.041

M3 - Journal article

SN - 0720-048X

VL - 77

SP - 202

EP - 206

JO - European Journal of Radiology

JF - European Journal of Radiology

IS - 2

ER -

Comparison of the manual and computer-aided techniques for evaluation of wrist synovitis using dynamic contrast-enhanced MRI on a dedicated scanner

Abstract

Access to Document

Fingerprint

Cite this