Abstract
The inhibitory capacity of calcium antagonists on basophil histamine release was examined in allergic patients and in controls. All dihydropyridines tested (nifedipine, nimodipine, nitrendipine, nicardipine, felodipine) dose-dependently inhibited anti-IgE- and A23187-induced release with an order of potency of felodipine greater than nicardipine greater than nifedipine = nimodipine = nitrendipine. Only the inhibition induced by felodipine and nicardipine on anti-IgE-induced release could be counteracted by increasing extracellular calcium. Diltiazem, not belonging to the dihydropyridines, was a weak inhibitor. A combination of felodipine and verapamil in low concentrations exerted a synergistic inhibitory effect on histamine release, whereas this was not the case with other combinations of antagonists. The results suggest differences in the mode of action of the 1.4-dihydropyridines. This might be of significance in the search for calcium antagonists suitable in the treatment of allergic diseases.
| Original language | English |
|---|---|
| Journal | Allergy: European Journal of Allergy and Clinical Immunology |
| Volume | 42 |
| Issue number | 6 |
| Pages (from-to) | 441-6 |
| Number of pages | 6 |
| ISSN | 0105-4538 |
| Publication status | Published - 1987 |
| Externally published | Yes |
Keywords
- Antibodies, Anti-Idiotypic
- Basophils
- Calcium Channel Blockers
- Histamine Release
- Humans
- Hypersensitivity
- Immunoglobulin E
- Ion Channels