Comparison of serum amyloid A and C-reactive protein as diagnostic markers of systemic inflammation in dogs

Michelle Brønniche Christensen; Rebecca Langhorn; Amelia Goddard; Eva Bartholin Andreasen; Elena Moldal; Asta Tvarijonaviciute; Jolle Kirpensteijn; Sabrina Jakobsen; Frida Persson; Mads Kjelgaard-Hansen

Comparison of serum amyloid A and C-reactive protein as diagnostic markers of systemic inflammation in dogs

Michelle Brønniche Christensen, Rebecca Langhorn, Amelia Goddard, Eva Bartholin Andreasen, Elena Moldal, Asta Tvarijonaviciute, Jolle Kirpensteijn, Sabrina Jakobsen, Frida Persson, Mads Kjelgaard-Hansen

39 Citations (Scopus)

Abstract

The diagnostic performance of canine serum amyloid A (SAA) was compared with that of C-reactive protein (CRP) in the detection of systemic inflammation in dogs. Sera from 500 dogs were retrospectively included in the study. C-reactive protein and SAA were measured using validated automated assays. The overlap performance, clinical decision limits, overall diagnostic performance, correlations, and agreement in the clinical classification between these 2 diagnostic markers were compared. Significantly higher concentrations of both proteins were detected in dogs with systemic inflammation (SAA range: 48.75 to > 2700 mg/L; CRP range: 0.4 to 907.4 mg/L) compared to dogs without systemic inflammation (SAA range: 1.06 to 56.4 mg/L; CRP range: 0.07 to 24.7 mg/L). Both proteins were shown to be sensitive and specific markers of systemic inflammation in dogs. Significant correlations and excellent diagnostic agreement were observed between the 2 markers. However, SAA showed a wider range of concentrations and a significantly superior overall diagnostic performance compared with CRP.

Original language	English
Journal	Canadian Veterinary Journal
Volume	55
Issue number	2
Pages (from-to)	161-168
Number of pages	8
ISSN	0008-5286
Publication status	Published - Feb 2014

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title = "Comparison of serum amyloid A and C-reactive protein as diagnostic markers of systemic inflammation in dogs",

abstract = "The diagnostic performance of canine serum amyloid A (SAA) was compared with that of C-reactive protein (CRP) in the detection of systemic inflammation in dogs. Sera from 500 dogs were retrospectively included in the study. C-reactive protein and SAA were measured using validated automated assays. The overlap performance, clinical decision limits, overall diagnostic performance, correlations, and agreement in the clinical classification between these 2 diagnostic markers were compared. Significantly higher concentrations of both proteins were detected in dogs with systemic inflammation (SAA range: 48.75 to > 2700 mg/L; CRP range: 0.4 to 907.4 mg/L) compared to dogs without systemic inflammation (SAA range: 1.06 to 56.4 mg/L; CRP range: 0.07 to 24.7 mg/L). Both proteins were shown to be sensitive and specific markers of systemic inflammation in dogs. Significant correlations and excellent diagnostic agreement were observed between the 2 markers. However, SAA showed a wider range of concentrations and a significantly superior overall diagnostic performance compared with CRP.",

author = "Christensen, {Michelle Br{\o}nniche} and Rebecca Langhorn and Amelia Goddard and Andreasen, {Eva Bartholin} and Elena Moldal and Asta Tvarijonaviciute and Jolle Kirpensteijn and Sabrina Jakobsen and Frida Persson and Mads Kjelgaard-Hansen",

year = "2014",

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language = "English",

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journal = "Canadian Veterinary Journal",

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T1 - Comparison of serum amyloid A and C-reactive protein as diagnostic markers of systemic inflammation in dogs

AU - Christensen, Michelle Brønniche

AU - Langhorn, Rebecca

AU - Goddard, Amelia

AU - Andreasen, Eva Bartholin

AU - Moldal, Elena

AU - Tvarijonaviciute, Asta

AU - Kirpensteijn, Jolle

AU - Jakobsen, Sabrina

AU - Persson, Frida

AU - Kjelgaard-Hansen, Mads

PY - 2014/2

Y1 - 2014/2

N2 - The diagnostic performance of canine serum amyloid A (SAA) was compared with that of C-reactive protein (CRP) in the detection of systemic inflammation in dogs. Sera from 500 dogs were retrospectively included in the study. C-reactive protein and SAA were measured using validated automated assays. The overlap performance, clinical decision limits, overall diagnostic performance, correlations, and agreement in the clinical classification between these 2 diagnostic markers were compared. Significantly higher concentrations of both proteins were detected in dogs with systemic inflammation (SAA range: 48.75 to > 2700 mg/L; CRP range: 0.4 to 907.4 mg/L) compared to dogs without systemic inflammation (SAA range: 1.06 to 56.4 mg/L; CRP range: 0.07 to 24.7 mg/L). Both proteins were shown to be sensitive and specific markers of systemic inflammation in dogs. Significant correlations and excellent diagnostic agreement were observed between the 2 markers. However, SAA showed a wider range of concentrations and a significantly superior overall diagnostic performance compared with CRP.

AB - The diagnostic performance of canine serum amyloid A (SAA) was compared with that of C-reactive protein (CRP) in the detection of systemic inflammation in dogs. Sera from 500 dogs were retrospectively included in the study. C-reactive protein and SAA were measured using validated automated assays. The overlap performance, clinical decision limits, overall diagnostic performance, correlations, and agreement in the clinical classification between these 2 diagnostic markers were compared. Significantly higher concentrations of both proteins were detected in dogs with systemic inflammation (SAA range: 48.75 to > 2700 mg/L; CRP range: 0.4 to 907.4 mg/L) compared to dogs without systemic inflammation (SAA range: 1.06 to 56.4 mg/L; CRP range: 0.07 to 24.7 mg/L). Both proteins were shown to be sensitive and specific markers of systemic inflammation in dogs. Significant correlations and excellent diagnostic agreement were observed between the 2 markers. However, SAA showed a wider range of concentrations and a significantly superior overall diagnostic performance compared with CRP.

M3 - Journal article

C2 - 24489396

SN - 0008-5286

VL - 55

SP - 161

EP - 168

JO - Canadian Veterinary Journal

JF - Canadian Veterinary Journal

IS - 2

ER -

Comparison of serum amyloid A and C-reactive protein as diagnostic markers of systemic inflammation in dogs

Abstract

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