Comparison of propofol and thiopental as anesthetic agents for electroconvulsive therapy: a randomized, blinded comparison of seizure duration, stimulus charge, clinical effect, and cognitive side effects

Jeanett Bauer; Ida Hageman; Henrik Dam; Armando Báez; Tom Bolwig; Jakob Roed; Niels Olsen; Martin Jørgensen; Jeanett Bauer; Ida Hageman; Henrik Dam; Armando Báez; Tom Bolwig; Jakob Roed; Niels Vidiendal Olsen; Martin Balslev Jørgensen

doi:10.1097/YCT.0b013e31818a0203

Comparison of propofol and thiopental as anesthetic agents for electroconvulsive therapy: a randomized, blinded comparison of seizure duration, stimulus charge, clinical effect, and cognitive side effects

Jeanett Bauer, Ida Hageman, Henrik Dam, Armando Báez, Tom Bolwig, Jakob Roed, Niels Olsen, Martin Jørgensen, Jeanett Bauer, Ida Hageman, Henrik Dam, Armando Báez, Tom Bolwig, Jakob Roed, Niels Vidiendal Olsen, Martin Balslev Jørgensen

51 Citations (Scopus)

Abstract

OBJECTIVES:: To compare propofol and thiopental as anesthetic agents for electroconvulsive therapy (ECT) with respect to seizure duration, stimulus charge, clinical effect, and cognitive side effects. METHODS:: Randomized, blinded study of 62 depressed patients treated with bilateral ECT. Algorithm-based charge dosing was used. RESULTS:: The mean seizure duration of the patients in the thiopental group was 36.3 seconds versus 25.7 seconds in the propofol group (P = 0.001). The charge per treatment was 79.5 mC in the thiopental group versus 109.8 mC in the propofol group (P = 0.026). Sixteen patients in the propofol group (52%) reached the highest electrical dose versus 8 patients (26%) in the thiopental group (P = 0.014). No difference in response to treatment or number of treatments was observed. The mean score on Mini-Mental State Examination (MMSE) was 28.9 in the thiopental group versus 26.8 in the propofol group (P = 0.014). However, age distribution of patients completing the study differed between the groups. CONCLUSIONS:: Propofol significantly decreases seizure duration without significant difference in the clinical outcome. Using the employed treatment algorithm, patients anesthetised with propofol received higher electrical charge. Mini-Mental State Examination scores suggest that this results in more severe cognitive side effects. Results, however, might be confounded by the differences in age distribution in the groups.

Original language	English
Journal	Journal of ECT
Volume	25
Issue number	2
Pages (from-to)	85-90
Number of pages	5
ISSN	1095-0680
DOIs	https://doi.org/10.1097/YCT.0b013e31818a0203 https://doi.org/10.1097/YCT.0b013e31818a0203
Publication status	Published - 2009

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Bauer, J., Hageman, I., Dam, H., Báez, A., Bolwig, T., Roed, J., Olsen, N., Jørgensen, M., Bauer, J., Hageman, I., Dam, H., Báez, A., Bolwig, T., Roed, J., Olsen, N. V., & Jørgensen, M. B. (2009). Comparison of propofol and thiopental as anesthetic agents for electroconvulsive therapy: a randomized, blinded comparison of seizure duration, stimulus charge, clinical effect, and cognitive side effects. Journal of ECT, 25(2), 85-90. https://doi.org/10.1097/YCT.0b013e31818a0203, https://doi.org/10.1097/YCT.0b013e31818a0203

Comparison of propofol and thiopental as anesthetic agents for electroconvulsive therapy: a randomized, blinded comparison of seizure duration, stimulus charge, clinical effect, and cognitive side effects. / Bauer, Jeanett; Hageman, Ida; Dam, Henrik et al.

In: Journal of ECT, Vol. 25, No. 2, 2009, p. 85-90.

Research output: Contribution to journal › Journal article › Research › peer-review

Bauer, J, Hageman, I, Dam, H, Báez, A, Bolwig, T, Roed, J, Olsen, N, Jørgensen, M, Bauer, J, Hageman, I, Dam, H, Báez, A, Bolwig, T, Roed, J, Olsen, NV & Jørgensen, MB 2009, 'Comparison of propofol and thiopental as anesthetic agents for electroconvulsive therapy: a randomized, blinded comparison of seizure duration, stimulus charge, clinical effect, and cognitive side effects', Journal of ECT, vol. 25, no. 2, pp. 85-90. https://doi.org/10.1097/YCT.0b013e31818a0203, https://doi.org/10.1097/YCT.0b013e31818a0203

Bauer J, Hageman I, Dam H, Báez A, Bolwig T, Roed J et al. Comparison of propofol and thiopental as anesthetic agents for electroconvulsive therapy: a randomized, blinded comparison of seizure duration, stimulus charge, clinical effect, and cognitive side effects. Journal of ECT. 2009;25(2):85-90. doi: 10.1097/YCT.0b013e31818a0203, http://dx.doi.org/10.1097/YCT.0b013e31818a0203

@article{aed08630f90f11ddb219000ea68e967b,

title = "Comparison of propofol and thiopental as anesthetic agents for electroconvulsive therapy: a randomized, blinded comparison of seizure duration, stimulus charge, clinical effect, and cognitive side effects",

abstract = "OBJECTIVES:: To compare propofol and thiopental as anesthetic agents for electroconvulsive therapy (ECT) with respect to seizure duration, stimulus charge, clinical effect, and cognitive side effects. METHODS:: Randomized, blinded study of 62 depressed patients treated with bilateral ECT. Algorithm-based charge dosing was used. RESULTS:: The mean seizure duration of the patients in the thiopental group was 36.3 seconds versus 25.7 seconds in the propofol group (P = 0.001). The charge per treatment was 79.5 mC in the thiopental group versus 109.8 mC in the propofol group (P = 0.026). Sixteen patients in the propofol group (52%) reached the highest electrical dose versus 8 patients (26%) in the thiopental group (P = 0.014). No difference in response to treatment or number of treatments was observed. The mean score on Mini-Mental State Examination (MMSE) was 28.9 in the thiopental group versus 26.8 in the propofol group (P = 0.014). However, age distribution of patients completing the study differed between the groups. CONCLUSIONS:: Propofol significantly decreases seizure duration without significant difference in the clinical outcome. Using the employed treatment algorithm, patients anesthetised with propofol received higher electrical charge. Mini-Mental State Examination scores suggest that this results in more severe cognitive side effects. Results, however, might be confounded by the differences in age distribution in the groups.",

author = "Jeanett Bauer and Ida Hageman and Henrik Dam and Armando B{\'a}ez and Tom Bolwig and Jakob Roed and Niels Olsen and Martin J{\o}rgensen and Jeanett Bauer and Ida Hageman and Henrik Dam and Armando B{\'a}ez and Tom Bolwig and Jakob Roed and Olsen, {Niels Vidiendal} and J{\o}rgensen, {Martin Balslev}",

note = "Keywords: Adult; Aged; Algorithms; Anesthesia, Intravenous; Anesthetics, Intravenous; Cognition Disorders; Double-Blind Method; Electroconvulsive Therapy; Female; Humans; Male; Middle Aged; Monitoring, Physiologic; Neuropsychological Tests; Propofol; Seizures; Thiopental; Young Adult",

year = "2009",

doi = "10.1097/YCT.0b013e31818a0203",

language = "English",

volume = "25",

pages = "85--90",

journal = "Journal of Electroconvulsive Therapy",

issn = "1095-0680",

publisher = "Lippincott Williams & Wilkins",

number = "2",

}

TY - JOUR

T1 - Comparison of propofol and thiopental as anesthetic agents for electroconvulsive therapy: a randomized, blinded comparison of seizure duration, stimulus charge, clinical effect, and cognitive side effects

AU - Bauer, Jeanett

AU - Hageman, Ida

AU - Dam, Henrik

AU - Báez, Armando

AU - Bolwig, Tom

AU - Roed, Jakob

AU - Olsen, Niels

AU - Jørgensen, Martin

AU - Bauer, Jeanett

AU - Hageman, Ida

AU - Dam, Henrik

AU - Báez, Armando

AU - Bolwig, Tom

AU - Roed, Jakob

AU - Olsen, Niels Vidiendal

AU - Jørgensen, Martin Balslev

N1 - Keywords: Adult; Aged; Algorithms; Anesthesia, Intravenous; Anesthetics, Intravenous; Cognition Disorders; Double-Blind Method; Electroconvulsive Therapy; Female; Humans; Male; Middle Aged; Monitoring, Physiologic; Neuropsychological Tests; Propofol; Seizures; Thiopental; Young Adult

PY - 2009

Y1 - 2009

N2 - OBJECTIVES:: To compare propofol and thiopental as anesthetic agents for electroconvulsive therapy (ECT) with respect to seizure duration, stimulus charge, clinical effect, and cognitive side effects. METHODS:: Randomized, blinded study of 62 depressed patients treated with bilateral ECT. Algorithm-based charge dosing was used. RESULTS:: The mean seizure duration of the patients in the thiopental group was 36.3 seconds versus 25.7 seconds in the propofol group (P = 0.001). The charge per treatment was 79.5 mC in the thiopental group versus 109.8 mC in the propofol group (P = 0.026). Sixteen patients in the propofol group (52%) reached the highest electrical dose versus 8 patients (26%) in the thiopental group (P = 0.014). No difference in response to treatment or number of treatments was observed. The mean score on Mini-Mental State Examination (MMSE) was 28.9 in the thiopental group versus 26.8 in the propofol group (P = 0.014). However, age distribution of patients completing the study differed between the groups. CONCLUSIONS:: Propofol significantly decreases seizure duration without significant difference in the clinical outcome. Using the employed treatment algorithm, patients anesthetised with propofol received higher electrical charge. Mini-Mental State Examination scores suggest that this results in more severe cognitive side effects. Results, however, might be confounded by the differences in age distribution in the groups.

AB - OBJECTIVES:: To compare propofol and thiopental as anesthetic agents for electroconvulsive therapy (ECT) with respect to seizure duration, stimulus charge, clinical effect, and cognitive side effects. METHODS:: Randomized, blinded study of 62 depressed patients treated with bilateral ECT. Algorithm-based charge dosing was used. RESULTS:: The mean seizure duration of the patients in the thiopental group was 36.3 seconds versus 25.7 seconds in the propofol group (P = 0.001). The charge per treatment was 79.5 mC in the thiopental group versus 109.8 mC in the propofol group (P = 0.026). Sixteen patients in the propofol group (52%) reached the highest electrical dose versus 8 patients (26%) in the thiopental group (P = 0.014). No difference in response to treatment or number of treatments was observed. The mean score on Mini-Mental State Examination (MMSE) was 28.9 in the thiopental group versus 26.8 in the propofol group (P = 0.014). However, age distribution of patients completing the study differed between the groups. CONCLUSIONS:: Propofol significantly decreases seizure duration without significant difference in the clinical outcome. Using the employed treatment algorithm, patients anesthetised with propofol received higher electrical charge. Mini-Mental State Examination scores suggest that this results in more severe cognitive side effects. Results, however, might be confounded by the differences in age distribution in the groups.

U2 - 10.1097/YCT.0b013e31818a0203

DO - 10.1097/YCT.0b013e31818a0203

M3 - Journal article

C2 - 19092676

SN - 1095-0680

VL - 25

SP - 85

EP - 90

JO - Journal of Electroconvulsive Therapy

JF - Journal of Electroconvulsive Therapy

IS - 2

ER -