Abstract
Heterotopic bone formation in the abdominal muscle of 45 male 8-week-old Wistar rats induced by implantation of 5, 10, or 15 mg demineralized bone (DBM) powder was evaluated at 4 weeks by 85Sr uptake of the implants and area histomorphometry of the induced bone. Two indices of 85Sr uptake were calculated: the osteogenic index [(counts/min/mg implant)/(counts/min/mg os ilium)] and an index that we have called the osteoquantum index in which the weight of the implant is disregarded [(counts/min implant)/(counts/min/mg os ilium)]. The osteoquantum index showed a linear relationship to the area of the induced bone with a correlation coefficient (r) of 0.90. Only weak linear relationships were found between the osteogenic index and the area of the bone (r = 0.32) and between the osteogenic index and the osteoquantum index (r = 0.33). The osteoquantum index and the area of the induced bone both increased with increasing mass of implanted DBM, whereas the osteogenic index did not change.
| Original language | English |
|---|---|
| Journal | Acta Orthopaedica Scandinavica |
| Volume | 63 |
| Issue number | 3 |
| Pages (from-to) | 334-8 |
| Number of pages | 5 |
| ISSN | 0001-6470 |
| Publication status | Published - 1 Jun 1992 |
Keywords
- Analysis of Variance
- Animals
- Bone Matrix
- Male
- Ossification, Heterotopic
- Rats
- Rats, Inbred Strains
- Regression Analysis
- Strontium Radioisotopes