Comparison of chloroquine with artesunate in the treatment of cerebral malaria in Ghanaian children

B Q Goka; V Adabayeri; E Ofori-Adjei; B Quarshie; G Asare-Odei; B D Akanmori; J Kurtzhals; D Ofori-Adjei; J Neequaye

Comparison of chloroquine with artesunate in the treatment of cerebral malaria in Ghanaian children

B Q Goka, V Adabayeri, E Ofori-Adjei, B Quarshie, G Asare-Odei, B D Akanmori, J Kurtzhals, D Ofori-Adjei, J Neequaye

1 Citation (Scopus)

Abstract

Despite previously reported chloroquine-resistant forms of PF falciparum in Ghana, chloroquine remains the drug of choice in severe malaria. Artemisinin derivatives have been shown to be effective against chloroquine-resistant strains in other endemic areas. This open randomized study was conducted to compare the efficacy of chloroquine and artesunate in the treatment of childhood cerebral malaria. Out of 82 subjects that fulfilled the inclusion criteria, 36 were randomized to receive chloroquine and 46 to receive artemisinin. Blantyre coma scores, temperature and parasitaemia were monitored. Mortality and neurological deficits were documented. There was no difference in mortality rates (chloroquine, 16.7 per cent; artesunate, 21.7 per cent; p = 0.6), neurological deficit at day 14 (chloroquine, 0 per cent; artesunate, 4.3 per cent; p = 0.3), resolution of fever (p = 0.55), and coma recovery time (p = 0.8), between the two groups. The results suggest that syrup chloroquine and intramuscular/oral artesunate currently give comparable clinical responses in the treatment of cerebral malaria in Ghana. Possible reasons for this are discussed, and suggestions are made for future antimalarial drug policy.

Original language	English
Journal	Journal of Tropical Pediatrics
Volume	47
Issue number	3
Pages (from-to)	165-9
Number of pages	4
ISSN	0142-6338
Publication status	Published - 2001

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@article{ed1f94600ce811df825d000ea68e967b,

title = "Comparison of chloroquine with artesunate in the treatment of cerebral malaria in Ghanaian children",

abstract = "Despite previously reported chloroquine-resistant forms of PF falciparum in Ghana, chloroquine remains the drug of choice in severe malaria. Artemisinin derivatives have been shown to be effective against chloroquine-resistant strains in other endemic areas. This open randomized study was conducted to compare the efficacy of chloroquine and artesunate in the treatment of childhood cerebral malaria. Out of 82 subjects that fulfilled the inclusion criteria, 36 were randomized to receive chloroquine and 46 to receive artemisinin. Blantyre coma scores, temperature and parasitaemia were monitored. Mortality and neurological deficits were documented. There was no difference in mortality rates (chloroquine, 16.7 per cent; artesunate, 21.7 per cent; p = 0.6), neurological deficit at day 14 (chloroquine, 0 per cent; artesunate, 4.3 per cent; p = 0.3), resolution of fever (p = 0.55), and coma recovery time (p = 0.8), between the two groups. The results suggest that syrup chloroquine and intramuscular/oral artesunate currently give comparable clinical responses in the treatment of cerebral malaria in Ghana. Possible reasons for this are discussed, and suggestions are made for future antimalarial drug policy.",

author = "Goka, {B Q} and V Adabayeri and E Ofori-Adjei and B Quarshie and G Asare-Odei and Akanmori, {B D} and J Kurtzhals and D Ofori-Adjei and J Neequaye",

note = "Keywords: Animals; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Female; Ghana; Humans; Malaria, Cerebral; Male; Plasmodium falciparum; Sesquiterpenes",

year = "2001",

language = "English",

volume = "47",

pages = "165--9",

journal = "Journal of Tropical Pediatrics",

issn = "0142-6338",

publisher = "Oxford University Press",

number = "3",

}

TY - JOUR

T1 - Comparison of chloroquine with artesunate in the treatment of cerebral malaria in Ghanaian children

AU - Goka, B Q

AU - Adabayeri, V

AU - Ofori-Adjei, E

AU - Quarshie, B

AU - Asare-Odei, G

AU - Akanmori, B D

AU - Kurtzhals, J

AU - Ofori-Adjei, D

AU - Neequaye, J

N1 - Keywords: Animals; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Female; Ghana; Humans; Malaria, Cerebral; Male; Plasmodium falciparum; Sesquiterpenes

PY - 2001

Y1 - 2001

N2 - Despite previously reported chloroquine-resistant forms of PF falciparum in Ghana, chloroquine remains the drug of choice in severe malaria. Artemisinin derivatives have been shown to be effective against chloroquine-resistant strains in other endemic areas. This open randomized study was conducted to compare the efficacy of chloroquine and artesunate in the treatment of childhood cerebral malaria. Out of 82 subjects that fulfilled the inclusion criteria, 36 were randomized to receive chloroquine and 46 to receive artemisinin. Blantyre coma scores, temperature and parasitaemia were monitored. Mortality and neurological deficits were documented. There was no difference in mortality rates (chloroquine, 16.7 per cent; artesunate, 21.7 per cent; p = 0.6), neurological deficit at day 14 (chloroquine, 0 per cent; artesunate, 4.3 per cent; p = 0.3), resolution of fever (p = 0.55), and coma recovery time (p = 0.8), between the two groups. The results suggest that syrup chloroquine and intramuscular/oral artesunate currently give comparable clinical responses in the treatment of cerebral malaria in Ghana. Possible reasons for this are discussed, and suggestions are made for future antimalarial drug policy.

AB - Despite previously reported chloroquine-resistant forms of PF falciparum in Ghana, chloroquine remains the drug of choice in severe malaria. Artemisinin derivatives have been shown to be effective against chloroquine-resistant strains in other endemic areas. This open randomized study was conducted to compare the efficacy of chloroquine and artesunate in the treatment of childhood cerebral malaria. Out of 82 subjects that fulfilled the inclusion criteria, 36 were randomized to receive chloroquine and 46 to receive artemisinin. Blantyre coma scores, temperature and parasitaemia were monitored. Mortality and neurological deficits were documented. There was no difference in mortality rates (chloroquine, 16.7 per cent; artesunate, 21.7 per cent; p = 0.6), neurological deficit at day 14 (chloroquine, 0 per cent; artesunate, 4.3 per cent; p = 0.3), resolution of fever (p = 0.55), and coma recovery time (p = 0.8), between the two groups. The results suggest that syrup chloroquine and intramuscular/oral artesunate currently give comparable clinical responses in the treatment of cerebral malaria in Ghana. Possible reasons for this are discussed, and suggestions are made for future antimalarial drug policy.

M3 - Journal article

C2 - 11419681

SN - 0142-6338

VL - 47

SP - 165

EP - 169

JO - Journal of Tropical Pediatrics

JF - Journal of Tropical Pediatrics

IS - 3

ER -

Comparison of chloroquine with artesunate in the treatment of cerebral malaria in Ghanaian children

Abstract

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