Abstract
Prediction of cumulative incidences is often a primary goal in clinical studies with several endpoints. We compare predictions among competing risks models with time-dependent covariates. For a series of landmark time points, we study the predictive accuracy of a multi-state regression model, where the time-dependent covariate represents an intermediate state, and two alternative landmark approaches. At each landmark time point, the prediction performance is measured as the t-year expected Brier score where pseudovalues are constructed in order to deal with right-censored event times. We apply the methods to data from a bone marrow transplant study where graft versus host disease is considered a time-dependent covariate for predicting relapse and death in remission.
| Original language | Undefined/Unknown |
|---|---|
| Journal | Statistics in Medicine |
| Volume | 32 |
| Issue number | 18 |
| Pages (from-to) | 3089-3101 |
| Number of pages | 13 |
| ISSN | 0277-6715 |
| Publication status | Published - 15 Aug 2013 |