Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity

Guojie Zhang; Christopher Cowled; Zhengli Shi; Zhiyong Huang; Kimberly A. Bishop-Lilly; Xiaodong Fang; James W. Wynne; Zhiqiang Xiong; Michelle L. Baker; Wei Zhao; Mary Tachedjian; Yabing Zhu; Peng Zhou; Xuanting Jiang; Justin Ng; Lan Yang; Lijun Wu; Jin Xiao; Yue Feng; Yuanxin Chen; Xiaoqing Sun; Yong Zhang; Glenn A. Marsh; Gary Crameri; Christopher C. Broder; Kenneth G. Frey; Lin-Fa Wang; Jun Wang

doi:10.1126/science.1230835

Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity

Guojie Zhang, Christopher Cowled, Zhengli Shi, Zhiyong Huang, Kimberly A. Bishop-Lilly, Xiaodong Fang, James W. Wynne, Zhiqiang Xiong, Michelle L. Baker, Wei Zhao, Mary Tachedjian, Yabing Zhu, Peng Zhou, Xuanting Jiang, Justin Ng, Lan Yang, Lijun Wu, Jin Xiao, Yue Feng, Yuanxin ChenXiaoqing Sun, Yong Zhang, Glenn A. Marsh, Gary Crameri, Christopher C. Broder, Kenneth G. Frey, Lin-Fa Wang, Jun Wang

Ecology and Evolution

322 Citations (Scopus)

Abstract

Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for some of the world's most highly pathogenic viruses, including Nipah, Hendra, Ebola, and severe acute respiratory syndrome (SARS). To identify genetic changes associated with the development of bat-specific traits, we performed whole-genome sequencing and comparative analyses of two distantly related species, fruit bat Pteropus alecto and insectivorous bat Myotis davidii. We discovered an unexpected concentration of positively selected genes in the DNA damage checkpoint and nuclear factor kB pathways that may be related to the origin of flight, as well as expansion and contraction of important gene families. Comparison of bat genomes with other mammalian species has provided new insights into bat biology and evolution.

Original language	English
Journal	Science (New York, N.Y.)
Volume	339
Issue number	6118
DOIs	https://doi.org/10.1126/science.1230835
Publication status	Published - 25 Jan 2013

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Zhang, G., Cowled, C., Shi, Z., Huang, Z., Bishop-Lilly, K. A., Fang, X., Wynne, J. W., Xiong, Z., Baker, M. L., Zhao, W., Tachedjian, M., Zhu, Y., Zhou, P., Jiang, X., Ng, J., Yang, L., Wu, L., Xiao, J., Feng, Y., ... Wang, J. (2013). Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity. Science (New York, N.Y.), 339(6118). https://doi.org/10.1126/science.1230835

Zhang, G, Cowled, C, Shi, Z, Huang, Z, Bishop-Lilly, KA, Fang, X, Wynne, JW, Xiong, Z, Baker, ML, Zhao, W, Tachedjian, M, Zhu, Y, Zhou, P, Jiang, X, Ng, J, Yang, L, Wu, L, Xiao, J, Feng, Y, Chen, Y, Sun, X, Zhang, Y, Marsh, GA, Crameri, G, Broder, CC, Frey, KG, Wang, L-F & Wang, J 2013, 'Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity', Science (New York, N.Y.), vol. 339, no. 6118. https://doi.org/10.1126/science.1230835

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title = "Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity",

abstract = "Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for some of the world's most highly pathogenic viruses, including Nipah, Hendra, Ebola, and severe acute respiratory syndrome (SARS). To identify genetic changes associated with the development of bat-specific traits, we performed whole-genome sequencing and comparative analyses of two distantly related species, fruit bat Pteropus alecto and insectivorous bat Myotis davidii. We discovered an unexpected concentration of positively selected genes in the DNA damage checkpoint and nuclear factor kB pathways that may be related to the origin of flight, as well as expansion and contraction of important gene families. Comparison of bat genomes with other mammalian species has provided new insights into bat biology and evolution.",

author = "Guojie Zhang and Christopher Cowled and Zhengli Shi and Zhiyong Huang and Bishop-Lilly, {Kimberly A.} and Xiaodong Fang and Wynne, {James W.} and Zhiqiang Xiong and Baker, {Michelle L.} and Wei Zhao and Mary Tachedjian and Yabing Zhu and Peng Zhou and Xuanting Jiang and Justin Ng and Lan Yang and Lijun Wu and Jin Xiao and Yue Feng and Yuanxin Chen and Xiaoqing Sun and Yong Zhang and Marsh, {Glenn A.} and Gary Crameri and Broder, {Christopher C.} and Frey, {Kenneth G.} and Lin-Fa Wang and Jun Wang",

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AU - Zhang, Guojie

AU - Cowled, Christopher

AU - Shi, Zhengli

AU - Huang, Zhiyong

AU - Bishop-Lilly, Kimberly A.

AU - Fang, Xiaodong

AU - Wynne, James W.

AU - Xiong, Zhiqiang

AU - Baker, Michelle L.

AU - Zhao, Wei

AU - Tachedjian, Mary

AU - Zhu, Yabing

AU - Zhou, Peng

AU - Jiang, Xuanting

AU - Ng, Justin

AU - Yang, Lan

AU - Wu, Lijun

AU - Xiao, Jin

AU - Feng, Yue

AU - Chen, Yuanxin

AU - Sun, Xiaoqing

AU - Zhang, Yong

AU - Marsh, Glenn A.

AU - Crameri, Gary

AU - Broder, Christopher C.

AU - Frey, Kenneth G.

AU - Wang, Lin-Fa

AU - Wang, Jun

PY - 2013/1/25

Y1 - 2013/1/25

N2 - Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for some of the world's most highly pathogenic viruses, including Nipah, Hendra, Ebola, and severe acute respiratory syndrome (SARS). To identify genetic changes associated with the development of bat-specific traits, we performed whole-genome sequencing and comparative analyses of two distantly related species, fruit bat Pteropus alecto and insectivorous bat Myotis davidii. We discovered an unexpected concentration of positively selected genes in the DNA damage checkpoint and nuclear factor kB pathways that may be related to the origin of flight, as well as expansion and contraction of important gene families. Comparison of bat genomes with other mammalian species has provided new insights into bat biology and evolution.

AB - Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for some of the world's most highly pathogenic viruses, including Nipah, Hendra, Ebola, and severe acute respiratory syndrome (SARS). To identify genetic changes associated with the development of bat-specific traits, we performed whole-genome sequencing and comparative analyses of two distantly related species, fruit bat Pteropus alecto and insectivorous bat Myotis davidii. We discovered an unexpected concentration of positively selected genes in the DNA damage checkpoint and nuclear factor kB pathways that may be related to the origin of flight, as well as expansion and contraction of important gene families. Comparison of bat genomes with other mammalian species has provided new insights into bat biology and evolution.

U2 - 10.1126/science.1230835

DO - 10.1126/science.1230835

M3 - Journal article

C2 - 23258410

SN - 0036-8075

VL - 339

JO - Science

JF - Science

IS - 6118

ER -

Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity

Abstract

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