Common variants of inflammatory cytokine genes are associated with risk of nephropathy in type 2 diabetes among Asian Indians.

Tarun Veer Singh Ahluwalia; Madhu Khullar; Monica Ahuja; Harbir Singh Kohli; Anil Bhansali; Viswanathan Mohan; Radha Venkatesan; Taranjit Singh Rai; Kamal Sud; Pawan K Singal

doi:10.1371/journal.pone.0005168

Common variants of inflammatory cytokine genes are associated with risk of nephropathy in type 2 diabetes among Asian Indians.

Tarun Veer Singh Ahluwalia, Madhu Khullar, Monica Ahuja, Harbir Singh Kohli, Anil Bhansali, Viswanathan Mohan, Radha Venkatesan, Taranjit Singh Rai, Kamal Sud, Pawan K Singal

53 Citations (Scopus)

Abstract

Inflammatory cytokine genes have been proposed as good candidate genes for conferring susceptibility to diabetic nephropathy. In the present study, we examined the combined effect of multiple alleles of pro inflammatory cytokine genes for determining the risk of nephropathy in type 2 diabetic patients.

Original language	English
Journal	PLOS ONE
Volume	4
Issue number	4
Pages (from-to)	e5168
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0005168
Publication status	Published - 2009

Keywords

Adult
Aged
C-Reactive Protein
Chemokine CCL2
Cytokines
Diabetes Mellitus, Type 2
Diabetic Nephropathies
Ethnic Groups
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
India
Interleukin-8
Male
Matrix Metalloproteinase 9
Middle Aged
Odds Ratio
Polymorphism, Single Nucleotide
Receptors, CCR5
Regression Analysis
Risk Factors
Transforming Growth Factor beta1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pone.0005168

http://www.ncbi.nlm.nih.gov/pubmed/19357773

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title = "Common variants of inflammatory cytokine genes are associated with risk of nephropathy in type 2 diabetes among Asian Indians.",

abstract = "Inflammatory cytokine genes have been proposed as good candidate genes for conferring susceptibility to diabetic nephropathy. In the present study, we examined the combined effect of multiple alleles of pro inflammatory cytokine genes for determining the risk of nephropathy in type 2 diabetic patients.",

keywords = "Adult, Aged, C-Reactive Protein, Chemokine CCL2, Cytokines, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Ethnic Groups, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, India, Interleukin-8, Male, Matrix Metalloproteinase 9, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide, Receptors, CCR5, Regression Analysis, Risk Factors, Transforming Growth Factor beta1",

author = "Ahluwalia, {Tarun Veer Singh} and Madhu Khullar and Monica Ahuja and Kohli, {Harbir Singh} and Anil Bhansali and Viswanathan Mohan and Radha Venkatesan and Rai, {Taranjit Singh} and Kamal Sud and Singal, {Pawan K}",

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doi = "10.1371/journal.pone.0005168",

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volume = "4",

pages = "e5168",

journal = "PLoS Computational Biology",

issn = "1932-6203",

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T1 - Common variants of inflammatory cytokine genes are associated with risk of nephropathy in type 2 diabetes among Asian Indians.

AU - Ahluwalia, Tarun Veer Singh

AU - Khullar, Madhu

AU - Ahuja, Monica

AU - Kohli, Harbir Singh

AU - Bhansali, Anil

AU - Mohan, Viswanathan

AU - Venkatesan, Radha

AU - Rai, Taranjit Singh

AU - Sud, Kamal

AU - Singal, Pawan K

PY - 2009

Y1 - 2009

N2 - Inflammatory cytokine genes have been proposed as good candidate genes for conferring susceptibility to diabetic nephropathy. In the present study, we examined the combined effect of multiple alleles of pro inflammatory cytokine genes for determining the risk of nephropathy in type 2 diabetic patients.

AB - Inflammatory cytokine genes have been proposed as good candidate genes for conferring susceptibility to diabetic nephropathy. In the present study, we examined the combined effect of multiple alleles of pro inflammatory cytokine genes for determining the risk of nephropathy in type 2 diabetic patients.

KW - Adult

KW - Aged

KW - C-Reactive Protein

KW - Chemokine CCL2

KW - Cytokines

KW - Diabetes Mellitus, Type 2

KW - Diabetic Nephropathies

KW - Ethnic Groups

KW - Female

KW - Gene Frequency

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - India

KW - Interleukin-8

KW - Male

KW - Matrix Metalloproteinase 9

KW - Middle Aged

KW - Odds Ratio

KW - Polymorphism, Single Nucleotide

KW - Receptors, CCR5

KW - Regression Analysis

KW - Risk Factors

KW - Transforming Growth Factor beta1

U2 - 10.1371/journal.pone.0005168

DO - 10.1371/journal.pone.0005168

M3 - Journal article

C2 - 19357773

SN - 1932-6203

VL - 4

SP - e5168

JO - PLoS Computational Biology

JF - PLoS Computational Biology

IS - 4

ER -

Common variants of inflammatory cytokine genes are associated with risk of nephropathy in type 2 diabetes among Asian Indians.

Abstract

Keywords

UN SDGs

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