Common variants at 19p13 are associated with susceptibility to ovarian cancer

Kelly L Bolton; Jonathan Tyrer; Honglin Song; Susan J Ramus; Maria Notaridou; Chris Jones; Tanya Sher; Aleksandra Gentry-Maharaj; Eva Wozniak; Ya-Yu Tsai; Joanne Weidhaas; Daniel Paik; David J Van Den Berg; Daniel O Stram; Celeste Leigh Pearce; Anna H Wu; Wendy Brewster; Hoda Anton-Culver; Argyrios Ziogas; Steven A Narod; Douglas A Levine; Stanley B Kaye; Robert Brown; Jim Paul; James Flanagan; Weiva Sieh; Valerie McGuire; Alice S Whittemore; Ian Campbell; Martin E Gore; Jolanta Lissowska; Hanna P Yang; Krzysztof Medrek; Jacek Gronwald; Jan Lubinski; Anna Jakubowska; Nhu D Le; Linda S Cook; Linda E Kelemen; Angela Brook-Wilson; Leon F A G Massuger; Lambertus A Kiemeney; Katja K H Aben; Anne M van Altena; Richard Houlston; Ian Tomlinson; Rachel T Palmieri; Patricia G Moorman; Estrid Vilma Solyom Høgdall; Claus Hogdall; Australian Ovarian Cancer Study Group

doi:http://dx.doi.org/10.1038/ng.666

Common variants at 19p13 are associated with susceptibility to ovarian cancer

Kelly L Bolton, Jonathan Tyrer, Honglin Song, Susan J Ramus, Maria Notaridou, Chris Jones, Tanya Sher, Aleksandra Gentry-Maharaj, Eva Wozniak, Ya-Yu Tsai, Joanne Weidhaas, Daniel Paik, David J Van Den Berg, Daniel O Stram, Celeste Leigh Pearce, Anna H Wu, Wendy Brewster, Hoda Anton-Culver, Argyrios Ziogas, Steven A NarodDouglas A Levine, Stanley B Kaye, Robert Brown, Jim Paul, James Flanagan, Weiva Sieh, Valerie McGuire, Alice S Whittemore, Ian Campbell, Martin E Gore, Jolanta Lissowska, Hanna P Yang, Krzysztof Medrek, Jacek Gronwald, Jan Lubinski, Anna Jakubowska, Nhu D Le, Linda S Cook, Linda E Kelemen, Angela Brook-Wilson, Leon F A G Massuger, Lambertus A Kiemeney, Katja K H Aben, Anne M van Altena, Richard Houlston, Ian Tomlinson, Rachel T Palmieri, Patricia G Moorman, Estrid Vilma Solyom Høgdall, Claus Hogdall, Australian Ovarian Cancer Study Group

Faculty of Health and Medical Sciences

199 Citations (Scopus)

Abstract

Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5×10^-4 and P = 6×10^-4, respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3×10^-9 and P = 4×10^-11, respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development.

Original language	English
Journal	Nature Genetics
Volume	42
Issue number	10
Pages (from-to)	880-4
Number of pages	5
ISSN	1061-4036
DOIs	https://doi.org/10.1038/ng.666
Publication status	Published - 1 Oct 2010

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Bolton, K. L., Tyrer, J., Song, H., Ramus, S. J., Notaridou, M., Jones, C., Sher, T., Gentry-Maharaj, A., Wozniak, E., Tsai, Y-Y., Weidhaas, J., Paik, D., Van Den Berg, D. J., Stram, D. O., Pearce, C. L., Wu, A. H., Brewster, W., Anton-Culver, H., Ziogas, A., ... Australian Ovarian Cancer Study Group (2010). Common variants at 19p13 are associated with susceptibility to ovarian cancer. Nature Genetics, 42(10), 880-4. https://doi.org/10.1038/ng.666

Bolton, KL, Tyrer, J, Song, H, Ramus, SJ, Notaridou, M, Jones, C, Sher, T, Gentry-Maharaj, A, Wozniak, E, Tsai, Y-Y, Weidhaas, J, Paik, D, Van Den Berg, DJ, Stram, DO, Pearce, CL, Wu, AH, Brewster, W, Anton-Culver, H, Ziogas, A, Narod, SA, Levine, DA, Kaye, SB, Brown, R, Paul, J, Flanagan, J, Sieh, W, McGuire, V, Whittemore, AS, Campbell, I, Gore, ME, Lissowska, J, Yang, HP, Medrek, K, Gronwald, J, Lubinski, J, Jakubowska, A, Le, ND, Cook, LS, Kelemen, LE, Brook-Wilson, A, Massuger, LFAG, Kiemeney, LA, Aben, KKH, van Altena, AM, Houlston, R, Tomlinson, I, Palmieri, RT, Moorman, PG, Høgdall, EVS , Hogdall, C & Australian Ovarian Cancer Study Group 2010, 'Common variants at 19p13 are associated with susceptibility to ovarian cancer', Nature Genetics, vol. 42, no. 10, pp. 880-4. https://doi.org/10.1038/ng.666

@article{94ee158a82f74c27a48d545766b69ea0,

title = "Common variants at 19p13 are associated with susceptibility to ovarian cancer",

abstract = "Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5×10-4 and P = 6×10-4, respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3×10-9 and P = 4×10-11, respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development.",

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T1 - Common variants at 19p13 are associated with susceptibility to ovarian cancer

AU - Bolton, Kelly L

AU - Tyrer, Jonathan

AU - Song, Honglin

AU - Ramus, Susan J

AU - Notaridou, Maria

AU - Jones, Chris

AU - Sher, Tanya

AU - Gentry-Maharaj, Aleksandra

AU - Wozniak, Eva

AU - Tsai, Ya-Yu

AU - Weidhaas, Joanne

AU - Paik, Daniel

AU - Van Den Berg, David J

AU - Stram, Daniel O

AU - Pearce, Celeste Leigh

AU - Wu, Anna H

AU - Brewster, Wendy

AU - Anton-Culver, Hoda

AU - Ziogas, Argyrios

AU - Narod, Steven A

AU - Levine, Douglas A

AU - Kaye, Stanley B

AU - Brown, Robert

AU - Paul, Jim

AU - Flanagan, James

AU - Sieh, Weiva

AU - McGuire, Valerie

AU - Whittemore, Alice S

AU - Campbell, Ian

AU - Gore, Martin E

AU - Lissowska, Jolanta

AU - Yang, Hanna P

AU - Medrek, Krzysztof

AU - Gronwald, Jacek

AU - Lubinski, Jan

AU - Jakubowska, Anna

AU - Le, Nhu D

AU - Cook, Linda S

AU - Kelemen, Linda E

AU - Brook-Wilson, Angela

AU - Massuger, Leon F A G

AU - Kiemeney, Lambertus A

AU - Aben, Katja K H

AU - van Altena, Anne M

AU - Houlston, Richard

AU - Tomlinson, Ian

AU - Palmieri, Rachel T

AU - Moorman, Patricia G

AU - Høgdall, Estrid Vilma Solyom

AU - Hogdall, Claus

AU - Australian Ovarian Cancer Study Group

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5×10-4 and P = 6×10-4, respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3×10-9 and P = 4×10-11, respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development.

AB - Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5×10-4 and P = 6×10-4, respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3×10-9 and P = 4×10-11, respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development.

U2 - http://dx.doi.org/10.1038/ng.666

DO - http://dx.doi.org/10.1038/ng.666

M3 - Journal article

SN - 1061-4036

VL - 42

SP - 880

EP - 884

JO - Nature: New biology

JF - Nature: New biology

IS - 10

ER -

Common variants at 19p13 are associated with susceptibility to ovarian cancer

Abstract

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