Common genomic signaling among initial DNA damage and radiation-induced apoptosis in peripheral blood lymphocytes from locally advanced breast cancer patients

Luis Alberto Henríquez-Hernández; Beatriz Pinar; Ruth Carmona-Vigo; Elisa Bordón; Carlos Rodríguez-Gallego; Amilcar Flores Morales; Pedro C Lara

doi:10.1016/j.breast.2012.05.005

Common genomic signaling among initial DNA damage and radiation-induced apoptosis in peripheral blood lymphocytes from locally advanced breast cancer patients

Luis Alberto Henríquez-Hernández, Beatriz Pinar, Ruth Carmona-Vigo, Elisa Bordón, Carlos Rodríguez-Gallego, Amilcar Flores Morales, Pedro C Lara

Novo Nordisk Foundation Center for Protein Research

7 Citations (Scopus)

Abstract

PURPOSE: To investigate the genomic signaling that defines sensitive lymphocytes to radiation and if such molecular profiles are consistent with clinical toxicity; trying to disclose the radiobiology mechanisms behind these cellular processes. PATIENTS AND METHODS: Twelve consecutive patients suffering from locally advanced breast cancer and treated with high-dose hyperfractionated radiotherapy were recruited. Initial DNA damage was measured by pulsed-field gel electrophoresis and radiation-induced apoptosis was measured by flow cytometry. Gene expression was assessed by DNA microarray. RESULTS: Thirty-four constitutive genes segregated patients with lower DNA-double strand break from those patients with higher DNA-double strand break (p

Original language	English
Journal	Breast (Edinburgh, Scotland)
Volume	22
Issue number	1
Pages (from-to)	28-33
Number of pages	6
DOIs	https://doi.org/10.1016/j.breast.2012.05.005
Publication status	Published - Feb 2013

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Henríquez-Hernández, L. A., Pinar, B., Carmona-Vigo, R., Bordón, E., Rodríguez-Gallego, C., Flores Morales, A., & Lara, P. C. (2013). Common genomic signaling among initial DNA damage and radiation-induced apoptosis in peripheral blood lymphocytes from locally advanced breast cancer patients. Breast (Edinburgh, Scotland), 22(1), 28-33. https://doi.org/10.1016/j.breast.2012.05.005

Common genomic signaling among initial DNA damage and radiation-induced apoptosis in peripheral blood lymphocytes from locally advanced breast cancer patients. / Henríquez-Hernández, Luis Alberto; Pinar, Beatriz; Carmona-Vigo, Ruth et al.

In: Breast (Edinburgh, Scotland), Vol. 22, No. 1, 02.2013, p. 28-33.

Research output: Contribution to journal › Journal article › Research › peer-review

Henríquez-Hernández, LA, Pinar, B, Carmona-Vigo, R, Bordón, E, Rodríguez-Gallego, C, Flores Morales, A & Lara, PC 2013, 'Common genomic signaling among initial DNA damage and radiation-induced apoptosis in peripheral blood lymphocytes from locally advanced breast cancer patients', Breast (Edinburgh, Scotland), vol. 22, no. 1, pp. 28-33. https://doi.org/10.1016/j.breast.2012.05.005

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abstract = "PURPOSE: To investigate the genomic signaling that defines sensitive lymphocytes to radiation and if such molecular profiles are consistent with clinical toxicity; trying to disclose the radiobiology mechanisms behind these cellular processes. PATIENTS AND METHODS: Twelve consecutive patients suffering from locally advanced breast cancer and treated with high-dose hyperfractionated radiotherapy were recruited. Initial DNA damage was measured by pulsed-field gel electrophoresis and radiation-induced apoptosis was measured by flow cytometry. Gene expression was assessed by DNA microarray. RESULTS: Thirty-four constitutive genes segregated patients with lower DNA-double strand break from those patients with higher DNA-double strand break (p ",

author = "Henr{\'i}quez-Hern{\'a}ndez, {Luis Alberto} and Beatriz Pinar and Ruth Carmona-Vigo and Elisa Bord{\'o}n and Carlos Rodr{\'i}guez-Gallego and {Flores Morales}, Amilcar and Lara, {Pedro C}",

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AU - Henríquez-Hernández, Luis Alberto

AU - Pinar, Beatriz

AU - Carmona-Vigo, Ruth

AU - Bordón, Elisa

AU - Rodríguez-Gallego, Carlos

AU - Flores Morales, Amilcar

AU - Lara, Pedro C

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N2 - PURPOSE: To investigate the genomic signaling that defines sensitive lymphocytes to radiation and if such molecular profiles are consistent with clinical toxicity; trying to disclose the radiobiology mechanisms behind these cellular processes. PATIENTS AND METHODS: Twelve consecutive patients suffering from locally advanced breast cancer and treated with high-dose hyperfractionated radiotherapy were recruited. Initial DNA damage was measured by pulsed-field gel electrophoresis and radiation-induced apoptosis was measured by flow cytometry. Gene expression was assessed by DNA microarray. RESULTS: Thirty-four constitutive genes segregated patients with lower DNA-double strand break from those patients with higher DNA-double strand break (p

AB - PURPOSE: To investigate the genomic signaling that defines sensitive lymphocytes to radiation and if such molecular profiles are consistent with clinical toxicity; trying to disclose the radiobiology mechanisms behind these cellular processes. PATIENTS AND METHODS: Twelve consecutive patients suffering from locally advanced breast cancer and treated with high-dose hyperfractionated radiotherapy were recruited. Initial DNA damage was measured by pulsed-field gel electrophoresis and radiation-induced apoptosis was measured by flow cytometry. Gene expression was assessed by DNA microarray. RESULTS: Thirty-four constitutive genes segregated patients with lower DNA-double strand break from those patients with higher DNA-double strand break (p

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Common genomic signaling among initial DNA damage and radiation-induced apoptosis in peripheral blood lymphocytes from locally advanced breast cancer patients

Abstract

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