Combining the Mannitol Test and FeNO in the Assessment of Poorly Controlled Asthma

Celeste Porsbjerg; Asger Sverrild; Vibeke Backer

doi:10.1016/j.jaip.2015.02.005

Combining the Mannitol Test and FeNO in the Assessment of Poorly Controlled Asthma

Celeste Porsbjerg, Asger Sverrild, Vibeke Backer

Department of Clinical Medicine

5 Citations (Scopus)

Abstract

BACKGROUND: International guidelines recommend up-titration of anti-inflammatory treatment in asthmatic patients with poor symptom control, but patients without eosinophilic airway inflammation are less likely to benefit from this. The mannitol bronchoprovocation test and fractional exhaled nitric oxide (FeNO) are increasingly used in the diagnostic assessment of asthma, but the utility of combining these tests has not been evaluated.

AIM: The aim of this study was to determine the value of combining FeNO and the mannitol test to assess patients with asthma referred for specialist assessment because of poor symptom control.

METHODS: All patients referred consecutively over a 12-month period for the assessment of asthma at the Respiratory Outpatient Clinic at Bispebjerg Hospital in Copenhagen were examined with bronchial provocation to mannitol, FeNO, and induced sputum.

RESULTS: Among asthmatic patients with partly controlled or uncontrolled symptoms according to Global Initiative for Asthma criteria, only 23% had sputum eosinophilia (eosinophils >2.99%). A positive mannitol test did not increase the likelihood of airway eosinophilia significantly (positive test: 32% vs negative test: 18%, P = .12). However, a positive mannitol test combined with a FeNO > 25 ppb indicated a high likelihood of airway eosinophilia (73%), compared with FeNO > 25 ppb and a negative mannitol test (29%) (P < .05). In contrast, in patients with FeNO < 25 ppb, a positive mannitol test was not associated with airway eosinophilia (sputum eosinophils > 2.99%: positive mannitol test: 0%, negative test: 11%, ns).

CONCLUSION: Combining the mannitol test and FeNO may aid in the differentiation between eosinophilic and noneosinophilic asthma in patients referred for specialist management because of poorly controlled asthma symptoms.

Original language	English
Journal	The Journal of Allergy and Clinical Immunology: In Practice
Volume	3
Issue number	4
Pages (from-to)	553-9
Number of pages	7
ISSN	2213-2198
DOIs	https://doi.org/10.1016/j.jaip.2015.02.005
Publication status	Published - 2015

Keywords

Administration, Inhalation
Adolescent
Adult
Asthma
Bronchial Provocation Tests
Eosinophilia
Female
Humans
Male
Mannitol
Middle Aged
Nitric Oxide
Skin Tests
Spirometry
Young Adult

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10.1016/j.jaip.2015.02.005

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@article{f284e9ccca2e4c01b7d8b98abc9b599d,

title = "Combining the Mannitol Test and FeNO in the Assessment of Poorly Controlled Asthma",

abstract = "BACKGROUND: International guidelines recommend up-titration of anti-inflammatory treatment in asthmatic patients with poor symptom control, but patients without eosinophilic airway inflammation are less likely to benefit from this. The mannitol bronchoprovocation test and fractional exhaled nitric oxide (FeNO) are increasingly used in the diagnostic assessment of asthma, but the utility of combining these tests has not been evaluated.AIM: The aim of this study was to determine the value of combining FeNO and the mannitol test to assess patients with asthma referred for specialist assessment because of poor symptom control.METHODS: All patients referred consecutively over a 12-month period for the assessment of asthma at the Respiratory Outpatient Clinic at Bispebjerg Hospital in Copenhagen were examined with bronchial provocation to mannitol, FeNO, and induced sputum.RESULTS: Among asthmatic patients with partly controlled or uncontrolled symptoms according to Global Initiative for Asthma criteria, only 23% had sputum eosinophilia (eosinophils >2.99%). A positive mannitol test did not increase the likelihood of airway eosinophilia significantly (positive test: 32% vs negative test: 18%, P = .12). However, a positive mannitol test combined with a FeNO > 25 ppb indicated a high likelihood of airway eosinophilia (73%), compared with FeNO > 25 ppb and a negative mannitol test (29%) (P < .05). In contrast, in patients with FeNO < 25 ppb, a positive mannitol test was not associated with airway eosinophilia (sputum eosinophils > 2.99%: positive mannitol test: 0%, negative test: 11%, ns).CONCLUSION: Combining the mannitol test and FeNO may aid in the differentiation between eosinophilic and noneosinophilic asthma in patients referred for specialist management because of poorly controlled asthma symptoms.",

keywords = "Administration, Inhalation, Adolescent, Adult, Asthma, Bronchial Provocation Tests, Eosinophilia, Female, Humans, Male, Mannitol, Middle Aged, Nitric Oxide, Skin Tests, Spirometry, Young Adult",

author = "Celeste Porsbjerg and Asger Sverrild and Vibeke Backer",

year = "2015",

doi = "10.1016/j.jaip.2015.02.005",

language = "English",

volume = "3",

pages = "553--9",

journal = "The Journal of Allergy and Clinical Immunology: In Practice",

issn = "2213-2198",

publisher = "Elsevier",

number = "4",

}

TY - JOUR

T1 - Combining the Mannitol Test and FeNO in the Assessment of Poorly Controlled Asthma

AU - Porsbjerg, Celeste

AU - Sverrild, Asger

AU - Backer, Vibeke

PY - 2015

Y1 - 2015

N2 - BACKGROUND: International guidelines recommend up-titration of anti-inflammatory treatment in asthmatic patients with poor symptom control, but patients without eosinophilic airway inflammation are less likely to benefit from this. The mannitol bronchoprovocation test and fractional exhaled nitric oxide (FeNO) are increasingly used in the diagnostic assessment of asthma, but the utility of combining these tests has not been evaluated.AIM: The aim of this study was to determine the value of combining FeNO and the mannitol test to assess patients with asthma referred for specialist assessment because of poor symptom control.METHODS: All patients referred consecutively over a 12-month period for the assessment of asthma at the Respiratory Outpatient Clinic at Bispebjerg Hospital in Copenhagen were examined with bronchial provocation to mannitol, FeNO, and induced sputum.RESULTS: Among asthmatic patients with partly controlled or uncontrolled symptoms according to Global Initiative for Asthma criteria, only 23% had sputum eosinophilia (eosinophils >2.99%). A positive mannitol test did not increase the likelihood of airway eosinophilia significantly (positive test: 32% vs negative test: 18%, P = .12). However, a positive mannitol test combined with a FeNO > 25 ppb indicated a high likelihood of airway eosinophilia (73%), compared with FeNO > 25 ppb and a negative mannitol test (29%) (P < .05). In contrast, in patients with FeNO < 25 ppb, a positive mannitol test was not associated with airway eosinophilia (sputum eosinophils > 2.99%: positive mannitol test: 0%, negative test: 11%, ns).CONCLUSION: Combining the mannitol test and FeNO may aid in the differentiation between eosinophilic and noneosinophilic asthma in patients referred for specialist management because of poorly controlled asthma symptoms.

AB - BACKGROUND: International guidelines recommend up-titration of anti-inflammatory treatment in asthmatic patients with poor symptom control, but patients without eosinophilic airway inflammation are less likely to benefit from this. The mannitol bronchoprovocation test and fractional exhaled nitric oxide (FeNO) are increasingly used in the diagnostic assessment of asthma, but the utility of combining these tests has not been evaluated.AIM: The aim of this study was to determine the value of combining FeNO and the mannitol test to assess patients with asthma referred for specialist assessment because of poor symptom control.METHODS: All patients referred consecutively over a 12-month period for the assessment of asthma at the Respiratory Outpatient Clinic at Bispebjerg Hospital in Copenhagen were examined with bronchial provocation to mannitol, FeNO, and induced sputum.RESULTS: Among asthmatic patients with partly controlled or uncontrolled symptoms according to Global Initiative for Asthma criteria, only 23% had sputum eosinophilia (eosinophils >2.99%). A positive mannitol test did not increase the likelihood of airway eosinophilia significantly (positive test: 32% vs negative test: 18%, P = .12). However, a positive mannitol test combined with a FeNO > 25 ppb indicated a high likelihood of airway eosinophilia (73%), compared with FeNO > 25 ppb and a negative mannitol test (29%) (P < .05). In contrast, in patients with FeNO < 25 ppb, a positive mannitol test was not associated with airway eosinophilia (sputum eosinophils > 2.99%: positive mannitol test: 0%, negative test: 11%, ns).CONCLUSION: Combining the mannitol test and FeNO may aid in the differentiation between eosinophilic and noneosinophilic asthma in patients referred for specialist management because of poorly controlled asthma symptoms.

KW - Administration, Inhalation

KW - Adolescent

KW - Adult

KW - Asthma

KW - Bronchial Provocation Tests

KW - Eosinophilia

KW - Female

KW - Humans

KW - Male

KW - Mannitol

KW - Middle Aged

KW - Nitric Oxide

KW - Skin Tests

KW - Spirometry

KW - Young Adult

U2 - 10.1016/j.jaip.2015.02.005

DO - 10.1016/j.jaip.2015.02.005

M3 - Journal article

C2 - 25824441

SN - 2213-2198

VL - 3

SP - 553

EP - 559

JO - The Journal of Allergy and Clinical Immunology: In Practice

JF - The Journal of Allergy and Clinical Immunology: In Practice

IS - 4

ER -

Combining the Mannitol Test and FeNO in the Assessment of Poorly Controlled Asthma

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Keywords

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