Combined heart rate- and accelerometer-assessed physical activity energy expenditure and associations with glucose homeostasis markers in a population at high risk of developing diabetes: the ADDITION-PRO study

Anne-Louise Smidt Hansen; Bendix Carstensen; Jørn Wulff Helge; Nanna B Johansen; Bibi Gram; Jens S Christiansen; Søren Brage; Torsten Lauritzen; Marit Eika Jørgensen; Mette Aadahl; Daniel R Witte; ADDITION-Denmark Steering Committee

doi:10.2337/dc12-2671

Combined heart rate- and accelerometer-assessed physical activity energy expenditure and associations with glucose homeostasis markers in a population at high risk of developing diabetes: the ADDITION-PRO study

Anne-Louise Smidt Hansen, Bendix Carstensen, Jørn Wulff Helge, Nanna B Johansen, Bibi Gram, Jens S Christiansen, Søren Brage, Torsten Lauritzen, Marit Eika Jørgensen, Mette Aadahl, Daniel R Witte, ADDITION-Denmark Steering Committee

24 Citations (Scopus)

Abstract

OBJECTIVE Regular physical activity (PA) reduces the risk of developing type 2 diabetes, and different subtypes of dysglycemia have shown different associations with PA. To better understand the associations of PAand glucose homeostasis,we examined the association of objectivelymeasured PA energy expenditure (PAEE) with detailed measures of glucose homeostasis. RESEARCH DESIGN AND METHODSdIn 1,531 men and women, with low to high risk of developing type 2 diabetes, we measured 7 days of PAEE using a combined accelerometry and heart rate monitor (ActiHeart). Measures and indices of glucose homeostasis were derived froma 3-point oral glucose tolerance test in addition tomeasures of long-term glycemia (glycated hemoglobin A1c and advanced glycation end products). Associations of PAEE with glucose homeostasis markers were examined using linear regression models. RESULTSdMedian age (IQR) was 66.6 years (62.1-71.6) (54%men) with amedian ActiHeart wear time of 6.9 days (6.0-7.1) and PAEE level of 33.0 kJ/kg/day (23.5-46.1). In fully adjusted models, we found higher levels of PAEE to be positively associated with insulin sensitivity and negatively with insulin 2 h after glucose load (P <0.05). CONCLUSIONSdEven in an elderly populationwith low levels of PA,we found higher objectively measured PAEE levels to be associated with a more beneficial glucose metabolic profile. Although our findings are cross-sectional, they indicate that evenwithout high-intensity exercise, increasing the overall level of PAEE slightly in an entire population at risk for developing type 2 diabetes may be a realistic and worthwhile goal to reach in order to achieve beneficial effect in terms of glucose metabolism.

Original language	English
Journal	Diabetes Care
Volume	36
Issue number	10
Pages (from-to)	3062-69
Number of pages	8
ISSN	0149-5992
DOIs	https://doi.org/10.2337/dc12-2671
Publication status	Published - Oct 2013

Keywords

Accelerometry
Aged
Blood Glucose
Diabetes Mellitus, Type 2
Energy Metabolism
Female
Heart Rate
Humans
Male
Middle Aged
Motor Activity

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Hansen, A.-L. S., Carstensen, B., Helge, J. W., Johansen, N. B., Gram, B., Christiansen, J. S., Brage, S., Lauritzen, T., Jørgensen, M. E., Aadahl, M., Witte, D. R., & ADDITION-Denmark Steering Committee (2013). Combined heart rate- and accelerometer-assessed physical activity energy expenditure and associations with glucose homeostasis markers in a population at high risk of developing diabetes: the ADDITION-PRO study. Diabetes Care, 36(10), 3062-69. https://doi.org/10.2337/dc12-2671

Combined heart rate- and accelerometer-assessed physical activity energy expenditure and associations with glucose homeostasis markers in a population at high risk of developing diabetes: the ADDITION-PRO study. / Hansen, Anne-Louise Smidt; Carstensen, Bendix ; Helge, Jørn Wulff et al.
In: Diabetes Care, Vol. 36, No. 10, 10.2013, p. 3062-69.

Research output: Contribution to journal › Journal article › Research › peer-review

Hansen, A-LS, Carstensen, B , Helge, JW, Johansen, NB, Gram, B, Christiansen, JS, Brage, S, Lauritzen, T, Jørgensen, ME, Aadahl, M, Witte, DR & ADDITION-Denmark Steering Committee 2013, 'Combined heart rate- and accelerometer-assessed physical activity energy expenditure and associations with glucose homeostasis markers in a population at high risk of developing diabetes: the ADDITION-PRO study', Diabetes Care, vol. 36, no. 10, pp. 3062-69. https://doi.org/10.2337/dc12-2671

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title = "Combined heart rate- and accelerometer-assessed physical activity energy expenditure and associations with glucose homeostasis markers in a population at high risk of developing diabetes: the ADDITION-PRO study",

abstract = "OBJECTIVE Regular physical activity (PA) reduces the risk of developing type 2 diabetes, and different subtypes of dysglycemia have shown different associations with PA. To better understand the associations of PAand glucose homeostasis,we examined the association of objectivelymeasured PA energy expenditure (PAEE) with detailed measures of glucose homeostasis. RESEARCH DESIGN AND METHODSdIn 1,531 men and women, with low to high risk of developing type 2 diabetes, we measured 7 days of PAEE using a combined accelerometry and heart rate monitor (ActiHeart). Measures and indices of glucose homeostasis were derived froma 3-point oral glucose tolerance test in addition tomeasures of long-term glycemia (glycated hemoglobin A1c and advanced glycation end products). Associations of PAEE with glucose homeostasis markers were examined using linear regression models. RESULTSdMedian age (IQR) was 66.6 years (62.1-71.6) (54%men) with amedian ActiHeart wear time of 6.9 days (6.0-7.1) and PAEE level of 33.0 kJ/kg/day (23.5-46.1). In fully adjusted models, we found higher levels of PAEE to be positively associated with insulin sensitivity and negatively with insulin 2 h after glucose load (P <0.05). CONCLUSIONSdEven in an elderly populationwith low levels of PA,we found higher objectively measured PAEE levels to be associated with a more beneficial glucose metabolic profile. Although our findings are cross-sectional, they indicate that evenwithout high-intensity exercise, increasing the overall level of PAEE slightly in an entire population at risk for developing type 2 diabetes may be a realistic and worthwhile goal to reach in order to achieve beneficial effect in terms of glucose metabolism.",

keywords = "Accelerometry, Aged, Blood Glucose, Diabetes Mellitus, Type 2, Energy Metabolism, Female, Heart Rate, Humans, Male, Middle Aged, Motor Activity",

author = "Hansen, {Anne-Louise Smidt} and Bendix Carstensen and Helge, {J{\o}rn Wulff} and Johansen, {Nanna B} and Bibi Gram and Christiansen, {Jens S} and S{\o}ren Brage and Torsten Lauritzen and J{\o}rgensen, {Marit Eika} and Mette Aadahl and Witte, {Daniel R} and {ADDITION-Denmark Steering Committee}",

year = "2013",

month = oct,

doi = "10.2337/dc12-2671",

language = "English",

volume = "36",

pages = "3062--69",

journal = "Diabetes Care",

issn = "0149-5992",

publisher = "American Diabetes Association",

number = "10",

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TY - JOUR

T1 - Combined heart rate- and accelerometer-assessed physical activity energy expenditure and associations with glucose homeostasis markers in a population at high risk of developing diabetes

T2 - the ADDITION-PRO study

AU - Hansen, Anne-Louise Smidt

AU - Carstensen, Bendix

AU - Helge, Jørn Wulff

AU - Johansen, Nanna B

AU - Gram, Bibi

AU - Christiansen, Jens S

AU - Brage, Søren

AU - Lauritzen, Torsten

AU - Jørgensen, Marit Eika

AU - Aadahl, Mette

AU - Witte, Daniel R

AU - ADDITION-Denmark Steering Committee

PY - 2013/10

Y1 - 2013/10

N2 - OBJECTIVE Regular physical activity (PA) reduces the risk of developing type 2 diabetes, and different subtypes of dysglycemia have shown different associations with PA. To better understand the associations of PAand glucose homeostasis,we examined the association of objectivelymeasured PA energy expenditure (PAEE) with detailed measures of glucose homeostasis. RESEARCH DESIGN AND METHODSdIn 1,531 men and women, with low to high risk of developing type 2 diabetes, we measured 7 days of PAEE using a combined accelerometry and heart rate monitor (ActiHeart). Measures and indices of glucose homeostasis were derived froma 3-point oral glucose tolerance test in addition tomeasures of long-term glycemia (glycated hemoglobin A1c and advanced glycation end products). Associations of PAEE with glucose homeostasis markers were examined using linear regression models. RESULTSdMedian age (IQR) was 66.6 years (62.1-71.6) (54%men) with amedian ActiHeart wear time of 6.9 days (6.0-7.1) and PAEE level of 33.0 kJ/kg/day (23.5-46.1). In fully adjusted models, we found higher levels of PAEE to be positively associated with insulin sensitivity and negatively with insulin 2 h after glucose load (P <0.05). CONCLUSIONSdEven in an elderly populationwith low levels of PA,we found higher objectively measured PAEE levels to be associated with a more beneficial glucose metabolic profile. Although our findings are cross-sectional, they indicate that evenwithout high-intensity exercise, increasing the overall level of PAEE slightly in an entire population at risk for developing type 2 diabetes may be a realistic and worthwhile goal to reach in order to achieve beneficial effect in terms of glucose metabolism.

AB - OBJECTIVE Regular physical activity (PA) reduces the risk of developing type 2 diabetes, and different subtypes of dysglycemia have shown different associations with PA. To better understand the associations of PAand glucose homeostasis,we examined the association of objectivelymeasured PA energy expenditure (PAEE) with detailed measures of glucose homeostasis. RESEARCH DESIGN AND METHODSdIn 1,531 men and women, with low to high risk of developing type 2 diabetes, we measured 7 days of PAEE using a combined accelerometry and heart rate monitor (ActiHeart). Measures and indices of glucose homeostasis were derived froma 3-point oral glucose tolerance test in addition tomeasures of long-term glycemia (glycated hemoglobin A1c and advanced glycation end products). Associations of PAEE with glucose homeostasis markers were examined using linear regression models. RESULTSdMedian age (IQR) was 66.6 years (62.1-71.6) (54%men) with amedian ActiHeart wear time of 6.9 days (6.0-7.1) and PAEE level of 33.0 kJ/kg/day (23.5-46.1). In fully adjusted models, we found higher levels of PAEE to be positively associated with insulin sensitivity and negatively with insulin 2 h after glucose load (P <0.05). CONCLUSIONSdEven in an elderly populationwith low levels of PA,we found higher objectively measured PAEE levels to be associated with a more beneficial glucose metabolic profile. Although our findings are cross-sectional, they indicate that evenwithout high-intensity exercise, increasing the overall level of PAEE slightly in an entire population at risk for developing type 2 diabetes may be a realistic and worthwhile goal to reach in order to achieve beneficial effect in terms of glucose metabolism.

KW - Accelerometry

KW - Aged

KW - Blood Glucose

KW - Diabetes Mellitus, Type 2

KW - Energy Metabolism

KW - Female

KW - Heart Rate

KW - Humans

KW - Male

KW - Middle Aged

KW - Motor Activity

U2 - 10.2337/dc12-2671

DO - 10.2337/dc12-2671

M3 - Journal article

C2 - 23757430

SN - 0149-5992

VL - 36

SP - 3062

EP - 3069

JO - Diabetes Care

JF - Diabetes Care

IS - 10

ER -