Collagenase in cranial morphogenesis

Kenn Holmbeck

doi:10.1159/000091377

Collagenase in cranial morphogenesis

4 Citations (Scopus)

Abstract

Collagen is the most abundant extracellular matrix protein in connective tissues of higher animals. The growth of connective tissues is intimately linked to the ability to model and remodel the collagen-rich matrices of the organism at critical points during development and growth to allow expansion and adaptation of tissue interfaces. The mammalian cranium is one such place where collagen remodeling is required for proper growth, and this review explores the consequences of abrogated collagen remodeling as they materialize in a mouse model deficient for the membrane type 1 matrix metalloproteinase.

Original language	English
Journal	Cells, Tissues, Organs
Volume	181
Issue number	3-4
Pages (from-to)	154-65
Number of pages	12
ISSN	1422-6405
DOIs	https://doi.org/10.1159/000091377
Publication status	Published - 2005

Keywords

Animals
Cartilage/metabolism
Collagen/metabolism
Collagenases/genetics
Matrix Metalloproteinases/genetics
Mice
Morphogenesis
Skull/enzymology
Tooth Eruption

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10.1159/000091377

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title = "Collagenase in cranial morphogenesis",

abstract = "Collagen is the most abundant extracellular matrix protein in connective tissues of higher animals. The growth of connective tissues is intimately linked to the ability to model and remodel the collagen-rich matrices of the organism at critical points during development and growth to allow expansion and adaptation of tissue interfaces. The mammalian cranium is one such place where collagen remodeling is required for proper growth, and this review explores the consequences of abrogated collagen remodeling as they materialize in a mouse model deficient for the membrane type 1 matrix metalloproteinase.",

keywords = "Animals, Cartilage/metabolism, Collagen/metabolism, Collagenases/genetics, Matrix Metalloproteinases/genetics, Mice, Morphogenesis, Skull/enzymology, Tooth Eruption",

author = "Kenn Holmbeck",

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AB - Collagen is the most abundant extracellular matrix protein in connective tissues of higher animals. The growth of connective tissues is intimately linked to the ability to model and remodel the collagen-rich matrices of the organism at critical points during development and growth to allow expansion and adaptation of tissue interfaces. The mammalian cranium is one such place where collagen remodeling is required for proper growth, and this review explores the consequences of abrogated collagen remodeling as they materialize in a mouse model deficient for the membrane type 1 matrix metalloproteinase.

KW - Animals

KW - Cartilage/metabolism

KW - Collagen/metabolism

KW - Collagenases/genetics

KW - Matrix Metalloproteinases/genetics

KW - Mice

KW - Morphogenesis

KW - Skull/enzymology

KW - Tooth Eruption

U2 - 10.1159/000091377

DO - 10.1159/000091377

M3 - Review

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SP - 154

EP - 165

JO - Cells Tissues Organs

JF - Cells Tissues Organs

IS - 3-4

ER -

Collagenase in cranial morphogenesis

Abstract

Keywords

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