Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism

Matthew D. Lynes; Farnaz Shamsi; Elahu Gosney Sustarsic; Luiz O. Leiria; Chih Hao Wang; Sheng Chiang Su; Tian Lian Huang; Fei Gao; Niven R. Narain; Emily Y. Chen; Aaron M. Cypess; Tim J. Schulz; Zachary Gerhart-Hines; Michael A. Kiebish; Yu Hua Tseng

doi:10.1016/j.celrep.2018.06.073

Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism

Matthew D. Lynes, Farnaz Shamsi, Elahu Gosney Sustarsic, Luiz O. Leiria, Chih Hao Wang, Sheng Chiang Su, Tian Lian Huang, Fei Gao, Niven R. Narain, Emily Y. Chen, Aaron M. Cypess, Tim J. Schulz, Zachary Gerhart-Hines, Michael A. Kiebish, Yu Hua Tseng^*

^*Corresponding author for this work

28 Citations (Scopus)

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Abstract

Thermogenic fat expends energy during cold for temperature homeostasis, and its activity regulates nutrient metabolism and insulin sensitivity. We measured cold-activated lipid landscapes in circulation and in adipose tissue by MS/MS^ALL shotgun lipidomics. We created an interactive online viewer to visualize the changes of specific lipid species in response to cold. In adipose tissue, among the approximately 1,600 lipid species profiled, we identified the biosynthetic pathway of the mitochondrial phospholipid cardiolipin as coordinately activated in brown and beige fat by cold in wild-type and transgenic mice with enhanced browning of white fat. Together, these data provide a comprehensive lipid bio-signature of thermogenic fat activation in circulation and tissue and suggest pathways regulated by cold exposure. In this resource, Lynes et al. use a sensitive MS/MS^ALL technique to profile over 1,000 lipid species in the blood and adipose tissue of humans and mice exposed to cold. Using the online viewer they created to view these data, pathways activated by cold exposure can be identified.

Original language	English
Journal	Cell Reports
Volume	24
Issue number	3
Pages (from-to)	781-790
Number of pages	10
ISSN	2211-1247
DOIs	https://doi.org/10.1016/j.celrep.2018.06.073
Publication status	Published - 2018

Keywords

brown adipose tissue
cardiolipin
lipidomics
thermogenesis
white adipose tissue

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Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic MetabolismFinal published version, 2.63 MBLicence: CC BY-NC-ND

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Lynes, M. D., Shamsi, F., Sustarsic, E. G., Leiria, L. O., Wang, C. H., Su, S. C., Huang, T. L., Gao, F., Narain, N. R., Chen, E. Y., Cypess, A. M., Schulz, T. J., Gerhart-Hines, Z., Kiebish, M. A., & Tseng, Y. H. (2018). Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism. Cell Reports, 24(3), 781-790. https://doi.org/10.1016/j.celrep.2018.06.073

Lynes, MD, Shamsi, F, Sustarsic, EG, Leiria, LO, Wang, CH, Su, SC, Huang, TL, Gao, F, Narain, NR, Chen, EY, Cypess, AM, Schulz, TJ, Gerhart-Hines, Z, Kiebish, MA & Tseng, YH 2018, 'Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism', Cell Reports, vol. 24, no. 3, pp. 781-790. https://doi.org/10.1016/j.celrep.2018.06.073

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title = "Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism",

abstract = "Thermogenic fat expends energy during cold for temperature homeostasis, and its activity regulates nutrient metabolism and insulin sensitivity. We measured cold-activated lipid landscapes in circulation and in adipose tissue by MS/MSALL shotgun lipidomics. We created an interactive online viewer to visualize the changes of specific lipid species in response to cold. In adipose tissue, among the approximately 1,600 lipid species profiled, we identified the biosynthetic pathway of the mitochondrial phospholipid cardiolipin as coordinately activated in brown and beige fat by cold in wild-type and transgenic mice with enhanced browning of white fat. Together, these data provide a comprehensive lipid bio-signature of thermogenic fat activation in circulation and tissue and suggest pathways regulated by cold exposure. In this resource, Lynes et al. use a sensitive MS/MSALL technique to profile over 1,000 lipid species in the blood and adipose tissue of humans and mice exposed to cold. Using the online viewer they created to view these data, pathways activated by cold exposure can be identified.",

keywords = "brown adipose tissue, cardiolipin, lipidomics, thermogenesis, white adipose tissue",

author = "Lynes, {Matthew D.} and Farnaz Shamsi and Sustarsic, {Elahu Gosney} and Leiria, {Luiz O.} and Wang, {Chih Hao} and Su, {Sheng Chiang} and Huang, {Tian Lian} and Fei Gao and Narain, {Niven R.} and Chen, {Emily Y.} and Cypess, {Aaron M.} and Schulz, {Tim J.} and Zachary Gerhart-Hines and Kiebish, {Michael A.} and Tseng, {Yu Hua}",

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AU - Lynes, Matthew D.

AU - Shamsi, Farnaz

AU - Sustarsic, Elahu Gosney

AU - Leiria, Luiz O.

AU - Wang, Chih Hao

AU - Su, Sheng Chiang

AU - Huang, Tian Lian

AU - Gao, Fei

AU - Narain, Niven R.

AU - Chen, Emily Y.

AU - Cypess, Aaron M.

AU - Schulz, Tim J.

AU - Gerhart-Hines, Zachary

AU - Kiebish, Michael A.

AU - Tseng, Yu Hua

PY - 2018

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N2 - Thermogenic fat expends energy during cold for temperature homeostasis, and its activity regulates nutrient metabolism and insulin sensitivity. We measured cold-activated lipid landscapes in circulation and in adipose tissue by MS/MSALL shotgun lipidomics. We created an interactive online viewer to visualize the changes of specific lipid species in response to cold. In adipose tissue, among the approximately 1,600 lipid species profiled, we identified the biosynthetic pathway of the mitochondrial phospholipid cardiolipin as coordinately activated in brown and beige fat by cold in wild-type and transgenic mice with enhanced browning of white fat. Together, these data provide a comprehensive lipid bio-signature of thermogenic fat activation in circulation and tissue and suggest pathways regulated by cold exposure. In this resource, Lynes et al. use a sensitive MS/MSALL technique to profile over 1,000 lipid species in the blood and adipose tissue of humans and mice exposed to cold. Using the online viewer they created to view these data, pathways activated by cold exposure can be identified.

AB - Thermogenic fat expends energy during cold for temperature homeostasis, and its activity regulates nutrient metabolism and insulin sensitivity. We measured cold-activated lipid landscapes in circulation and in adipose tissue by MS/MSALL shotgun lipidomics. We created an interactive online viewer to visualize the changes of specific lipid species in response to cold. In adipose tissue, among the approximately 1,600 lipid species profiled, we identified the biosynthetic pathway of the mitochondrial phospholipid cardiolipin as coordinately activated in brown and beige fat by cold in wild-type and transgenic mice with enhanced browning of white fat. Together, these data provide a comprehensive lipid bio-signature of thermogenic fat activation in circulation and tissue and suggest pathways regulated by cold exposure. In this resource, Lynes et al. use a sensitive MS/MSALL technique to profile over 1,000 lipid species in the blood and adipose tissue of humans and mice exposed to cold. Using the online viewer they created to view these data, pathways activated by cold exposure can be identified.

KW - brown adipose tissue

KW - cardiolipin

KW - lipidomics

KW - thermogenesis

KW - white adipose tissue

U2 - 10.1016/j.celrep.2018.06.073

DO - 10.1016/j.celrep.2018.06.073

M3 - Journal article

C2 - 30021173

AN - SCOPUS:85049754305

SN - 2639-1856

VL - 24

SP - 781

EP - 790

JO - Cell Reports

JF - Cell Reports

IS - 3

ER -

Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism

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Keywords

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