Coarse and fine particles but not ultrafine particles in urban air trigger hospital admission for asthma in children

Amne Iskandar; Zorana Jovanovic Andersen; Klaus Bønnelykke; Thomas Ellermann; Klaus Kaae Andersen; Hans Bisgaard

doi:10.1136/thoraxjnl-2011-200324

Coarse and fine particles but not ultrafine particles in urban air trigger hospital admission for asthma in children

Amne Iskandar, Zorana Jovanovic Andersen, Klaus Bønnelykke, Thomas Ellermann, Klaus Kaae Andersen, Hans Bisgaard

108 Citations (Scopus)

Abstract

BackgroundShort-term exposure to air pollution can trigger hospital admissions for asthma in children, but it is not known which components of air pollution are most important. There are no available studies on the particular effect of ultrafine particles (UFPs) on paediatric admissions for asthma.AimTo study whether short-term exposure to air pollution is associated with hospital admissions for asthma in children. It is hypothesised that (1) the association between asthma admissions and air pollution is stronger with UFPs than with coarse (PM(10)) and fine (PM(2.5)) particles, nitrogen oxides (NO(x)) or nitrogen dioxide (NO(2)); and (2) infants are more susceptible to the effects of exposure to air pollution than older children.MethodDaily counts of admissions for asthma in children aged 0-18 years to hospitals located within a 15 km radius of the central fixed background urban air pollution measurement station in Copenhagen between 2001 and 2008 were extracted from the Danish National Patient Registry. A time-stratified case crossover design was applied and data were analysed using conditional logistic regression to estimate the effect of air pollution on asthma admissions.ResultsA significant association was found between hospital admissions for asthma in children aged 0-18 years and NO(x) (OR 1.11; 95% CI 1.05 to 1.17), NO(2) (1.10; 95% CI 1.04 to 1.16), PM(10) (1.07; 95% CI 1.03 to 1.12) and PM(2.5) (1.09; 95% CI 1.04 to 1.13); there was no association with UFPs. The association was stronger in infants than in older children for all pollutants, but no statistically significant interaction was detected.ConclusionShort-term exposure to air pollution can trigger hospital admission for asthma in children, with infants possibly being most susceptible. These effects seemed to be mediated by larger particles and traffic-related gases, whereas UFPs showed no effect.

Original language	English
Journal	Thorax
Volume	67
Issue number	3
Pages (from-to)	252-7
Number of pages	6
ISSN	0040-6376
DOIs	https://doi.org/10.1136/thoraxjnl-2011-200324
Publication status	Published - Mar 2012

Keywords

Adolescent
Age Factors
Asthma
Child
Child, Preschool
Cross-Over Studies
Denmark
Environmental Monitoring
Epidemiological Monitoring
Hospitalization
Humans
Infant
Infant, Newborn
Nitrogen Dioxide
Nitrogen Oxides
Particle Size
Particulate Matter
Sex Factors
Urban Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1136/thoraxjnl-2011-200324

Cite this

@article{6bf4d62282224962aab3c424a54558ca,

title = "Coarse and fine particles but not ultrafine particles in urban air trigger hospital admission for asthma in children",

abstract = "BackgroundShort-term exposure to air pollution can trigger hospital admissions for asthma in children, but it is not known which components of air pollution are most important. There are no available studies on the particular effect of ultrafine particles (UFPs) on paediatric admissions for asthma.AimTo study whether short-term exposure to air pollution is associated with hospital admissions for asthma in children. It is hypothesised that (1) the association between asthma admissions and air pollution is stronger with UFPs than with coarse (PM(10)) and fine (PM(2.5)) particles, nitrogen oxides (NO(x)) or nitrogen dioxide (NO(2)); and (2) infants are more susceptible to the effects of exposure to air pollution than older children.MethodDaily counts of admissions for asthma in children aged 0-18 years to hospitals located within a 15 km radius of the central fixed background urban air pollution measurement station in Copenhagen between 2001 and 2008 were extracted from the Danish National Patient Registry. A time-stratified case crossover design was applied and data were analysed using conditional logistic regression to estimate the effect of air pollution on asthma admissions.ResultsA significant association was found between hospital admissions for asthma in children aged 0-18 years and NO(x) (OR 1.11; 95% CI 1.05 to 1.17), NO(2) (1.10; 95% CI 1.04 to 1.16), PM(10) (1.07; 95% CI 1.03 to 1.12) and PM(2.5) (1.09; 95% CI 1.04 to 1.13); there was no association with UFPs. The association was stronger in infants than in older children for all pollutants, but no statistically significant interaction was detected.ConclusionShort-term exposure to air pollution can trigger hospital admission for asthma in children, with infants possibly being most susceptible. These effects seemed to be mediated by larger particles and traffic-related gases, whereas UFPs showed no effect.",

keywords = "Adolescent, Age Factors, Asthma, Child, Child, Preschool, Cross-Over Studies, Denmark, Environmental Monitoring, Epidemiological Monitoring, Hospitalization, Humans, Infant, Infant, Newborn, Nitrogen Dioxide, Nitrogen Oxides, Particle Size, Particulate Matter, Sex Factors, Urban Health",

author = "Amne Iskandar and Andersen, {Zorana Jovanovic} and Klaus B{\o}nnelykke and Thomas Ellermann and Andersen, {Klaus Kaae} and Hans Bisgaard",

year = "2012",

month = mar,

doi = "10.1136/thoraxjnl-2011-200324",

language = "English",

volume = "67",

pages = "252--7",

journal = "Thorax",

issn = "0040-6376",

publisher = "B M J Group",

number = "3",

}

TY - JOUR

T1 - Coarse and fine particles but not ultrafine particles in urban air trigger hospital admission for asthma in children

AU - Iskandar, Amne

AU - Andersen, Zorana Jovanovic

AU - Bønnelykke, Klaus

AU - Ellermann, Thomas

AU - Andersen, Klaus Kaae

AU - Bisgaard, Hans

PY - 2012/3

Y1 - 2012/3

N2 - BackgroundShort-term exposure to air pollution can trigger hospital admissions for asthma in children, but it is not known which components of air pollution are most important. There are no available studies on the particular effect of ultrafine particles (UFPs) on paediatric admissions for asthma.AimTo study whether short-term exposure to air pollution is associated with hospital admissions for asthma in children. It is hypothesised that (1) the association between asthma admissions and air pollution is stronger with UFPs than with coarse (PM(10)) and fine (PM(2.5)) particles, nitrogen oxides (NO(x)) or nitrogen dioxide (NO(2)); and (2) infants are more susceptible to the effects of exposure to air pollution than older children.MethodDaily counts of admissions for asthma in children aged 0-18 years to hospitals located within a 15 km radius of the central fixed background urban air pollution measurement station in Copenhagen between 2001 and 2008 were extracted from the Danish National Patient Registry. A time-stratified case crossover design was applied and data were analysed using conditional logistic regression to estimate the effect of air pollution on asthma admissions.ResultsA significant association was found between hospital admissions for asthma in children aged 0-18 years and NO(x) (OR 1.11; 95% CI 1.05 to 1.17), NO(2) (1.10; 95% CI 1.04 to 1.16), PM(10) (1.07; 95% CI 1.03 to 1.12) and PM(2.5) (1.09; 95% CI 1.04 to 1.13); there was no association with UFPs. The association was stronger in infants than in older children for all pollutants, but no statistically significant interaction was detected.ConclusionShort-term exposure to air pollution can trigger hospital admission for asthma in children, with infants possibly being most susceptible. These effects seemed to be mediated by larger particles and traffic-related gases, whereas UFPs showed no effect.

AB - BackgroundShort-term exposure to air pollution can trigger hospital admissions for asthma in children, but it is not known which components of air pollution are most important. There are no available studies on the particular effect of ultrafine particles (UFPs) on paediatric admissions for asthma.AimTo study whether short-term exposure to air pollution is associated with hospital admissions for asthma in children. It is hypothesised that (1) the association between asthma admissions and air pollution is stronger with UFPs than with coarse (PM(10)) and fine (PM(2.5)) particles, nitrogen oxides (NO(x)) or nitrogen dioxide (NO(2)); and (2) infants are more susceptible to the effects of exposure to air pollution than older children.MethodDaily counts of admissions for asthma in children aged 0-18 years to hospitals located within a 15 km radius of the central fixed background urban air pollution measurement station in Copenhagen between 2001 and 2008 were extracted from the Danish National Patient Registry. A time-stratified case crossover design was applied and data were analysed using conditional logistic regression to estimate the effect of air pollution on asthma admissions.ResultsA significant association was found between hospital admissions for asthma in children aged 0-18 years and NO(x) (OR 1.11; 95% CI 1.05 to 1.17), NO(2) (1.10; 95% CI 1.04 to 1.16), PM(10) (1.07; 95% CI 1.03 to 1.12) and PM(2.5) (1.09; 95% CI 1.04 to 1.13); there was no association with UFPs. The association was stronger in infants than in older children for all pollutants, but no statistically significant interaction was detected.ConclusionShort-term exposure to air pollution can trigger hospital admission for asthma in children, with infants possibly being most susceptible. These effects seemed to be mediated by larger particles and traffic-related gases, whereas UFPs showed no effect.

KW - Adolescent

KW - Age Factors

KW - Asthma

KW - Child

KW - Child, Preschool

KW - Cross-Over Studies

KW - Denmark

KW - Environmental Monitoring

KW - Epidemiological Monitoring

KW - Hospitalization

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Nitrogen Dioxide

KW - Nitrogen Oxides

KW - Particle Size

KW - Particulate Matter

KW - Sex Factors

KW - Urban Health

U2 - 10.1136/thoraxjnl-2011-200324

DO - 10.1136/thoraxjnl-2011-200324

M3 - Journal article

C2 - 22156960

SN - 0040-6376

VL - 67

SP - 252

EP - 257

JO - Thorax

JF - Thorax

IS - 3

ER -

Coarse and fine particles but not ultrafine particles in urban air trigger hospital admission for asthma in children

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this