Clustering of autoimmune diseases in patients with rosacea

Alexander Egeberg; Peter Riis Hansen; Gunnar Hilmar Gislason; Jacob Pontoppidan Thyssen

doi:10.1016/j.jaad.2015.11.004

Clustering of autoimmune diseases in patients with rosacea

Alexander Egeberg, Peter Riis Hansen, Gunnar Hilmar Gislason, Jacob Pontoppidan Thyssen

Department of Clinical Medicine

37 Citations (Scopus)

Abstract

BACKGROUND: Rosacea is a common inflammatory skin condition that shares genetic risk loci with autoimmune diseases such as type 1 diabetes mellitus (T1DM) and celiac disease. A recent genomewide association study identified 90 genetic regions associated with T1DM, celiac disease, multiple sclerosis, and/or rheumatoid arthritis, respectively. However, a possible association with rosacea was not investigated.

OBJECTIVE: We evaluated the association between rosacea and T1DM, celiac disease, multiple sclerosis, and rheumatoid arthritis, respectively.

METHODS: We performed a population-based case-control study. A total of 6759 patients with rosacea were identified and matched with 33,795 control subjects on age, sex, and calendar time. We used conditional logistic regression to calculate crude and adjusted odds ratios (ORs) with 95% confidence intervals (CIs).

RESULTS: After adjustment for smoking and socioeconomic status, patients with rosacea had significantly increased ORs for T1DM (OR 2.59, 95% CI 1.41-4.73), celiac disease (OR 2.03, 95% CI 1.35-3.07), multiple sclerosis (OR 1.65, 95% CI 1.20-2.28), and rheumatoid arthritis (OR 2.14, 95% CI 1.82-2.52). The association was mainly observed in women.

LIMITATIONS: We were unable to distinguish between the different subtypes and severities of rosacea.

CONCLUSIONS: Rosacea is associated with T1DM, celiac disease, multiple sclerosis, and rheumatoid arthritis, respectively, in women, whereas the association in men only reached statistical significance for rheumatoid arthritis.

Original language	English
Journal	Journal of the American Academy of Dermatology
Volume	74
Issue number	4
Pages (from-to)	667-72.e1
Number of pages	7
ISSN	0190-9622
DOIs	https://doi.org/10.1016/j.jaad.2015.11.004
Publication status	Published - 1 Apr 2016

Keywords

Adult
Age Distribution
Autoimmune Diseases
Case-Control Studies
Celiac Disease
Cluster Analysis
Comorbidity
Confidence Intervals
Databases, Factual
Denmark
Diabetes Mellitus, Type 1
Female
Genome-Wide Association Study
Humans
Incidence
Logistic Models
Male
Middle Aged
Odds Ratio
Retrospective Studies
Rheumatic Fever
Risk Assessment
Rosacea
Sex Distribution
Young Adult
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jaad.2015.11.004

http://www.jaad.org/article/S0190962215024652/pdf

Cite this

@article{bcafd3bda4e640879c8bdf76833bfcd7,

title = "Clustering of autoimmune diseases in patients with rosacea",

abstract = "BACKGROUND: Rosacea is a common inflammatory skin condition that shares genetic risk loci with autoimmune diseases such as type 1 diabetes mellitus (T1DM) and celiac disease. A recent genomewide association study identified 90 genetic regions associated with T1DM, celiac disease, multiple sclerosis, and/or rheumatoid arthritis, respectively. However, a possible association with rosacea was not investigated.OBJECTIVE: We evaluated the association between rosacea and T1DM, celiac disease, multiple sclerosis, and rheumatoid arthritis, respectively.METHODS: We performed a population-based case-control study. A total of 6759 patients with rosacea were identified and matched with 33,795 control subjects on age, sex, and calendar time. We used conditional logistic regression to calculate crude and adjusted odds ratios (ORs) with 95% confidence intervals (CIs).RESULTS: After adjustment for smoking and socioeconomic status, patients with rosacea had significantly increased ORs for T1DM (OR 2.59, 95% CI 1.41-4.73), celiac disease (OR 2.03, 95% CI 1.35-3.07), multiple sclerosis (OR 1.65, 95% CI 1.20-2.28), and rheumatoid arthritis (OR 2.14, 95% CI 1.82-2.52). The association was mainly observed in women.LIMITATIONS: We were unable to distinguish between the different subtypes and severities of rosacea.CONCLUSIONS: Rosacea is associated with T1DM, celiac disease, multiple sclerosis, and rheumatoid arthritis, respectively, in women, whereas the association in men only reached statistical significance for rheumatoid arthritis.",

keywords = "Adult, Age Distribution, Autoimmune Diseases, Case-Control Studies, Celiac Disease, Cluster Analysis, Comorbidity, Confidence Intervals, Databases, Factual, Denmark, Diabetes Mellitus, Type 1, Female, Genome-Wide Association Study, Humans, Incidence, Logistic Models, Male, Middle Aged, Odds Ratio, Retrospective Studies, Rheumatic Fever, Risk Assessment, Rosacea, Sex Distribution, Young Adult, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't",

author = "Alexander Egeberg and Hansen, {Peter Riis} and Gislason, {Gunnar Hilmar} and Thyssen, {Jacob Pontoppidan}",

year = "2016",

month = apr,

day = "1",

doi = "10.1016/j.jaad.2015.11.004",

language = "English",

volume = "74",

pages = "667--72.e1",

journal = "Journal of the American Academy of Dermatology",

issn = "0190-9622",

publisher = "Mosby Inc.",

number = "4",

}

TY - JOUR

T1 - Clustering of autoimmune diseases in patients with rosacea

AU - Egeberg, Alexander

AU - Hansen, Peter Riis

AU - Gislason, Gunnar Hilmar

AU - Thyssen, Jacob Pontoppidan

PY - 2016/4/1

Y1 - 2016/4/1

N2 - BACKGROUND: Rosacea is a common inflammatory skin condition that shares genetic risk loci with autoimmune diseases such as type 1 diabetes mellitus (T1DM) and celiac disease. A recent genomewide association study identified 90 genetic regions associated with T1DM, celiac disease, multiple sclerosis, and/or rheumatoid arthritis, respectively. However, a possible association with rosacea was not investigated.OBJECTIVE: We evaluated the association between rosacea and T1DM, celiac disease, multiple sclerosis, and rheumatoid arthritis, respectively.METHODS: We performed a population-based case-control study. A total of 6759 patients with rosacea were identified and matched with 33,795 control subjects on age, sex, and calendar time. We used conditional logistic regression to calculate crude and adjusted odds ratios (ORs) with 95% confidence intervals (CIs).RESULTS: After adjustment for smoking and socioeconomic status, patients with rosacea had significantly increased ORs for T1DM (OR 2.59, 95% CI 1.41-4.73), celiac disease (OR 2.03, 95% CI 1.35-3.07), multiple sclerosis (OR 1.65, 95% CI 1.20-2.28), and rheumatoid arthritis (OR 2.14, 95% CI 1.82-2.52). The association was mainly observed in women.LIMITATIONS: We were unable to distinguish between the different subtypes and severities of rosacea.CONCLUSIONS: Rosacea is associated with T1DM, celiac disease, multiple sclerosis, and rheumatoid arthritis, respectively, in women, whereas the association in men only reached statistical significance for rheumatoid arthritis.

AB - BACKGROUND: Rosacea is a common inflammatory skin condition that shares genetic risk loci with autoimmune diseases such as type 1 diabetes mellitus (T1DM) and celiac disease. A recent genomewide association study identified 90 genetic regions associated with T1DM, celiac disease, multiple sclerosis, and/or rheumatoid arthritis, respectively. However, a possible association with rosacea was not investigated.OBJECTIVE: We evaluated the association between rosacea and T1DM, celiac disease, multiple sclerosis, and rheumatoid arthritis, respectively.METHODS: We performed a population-based case-control study. A total of 6759 patients with rosacea were identified and matched with 33,795 control subjects on age, sex, and calendar time. We used conditional logistic regression to calculate crude and adjusted odds ratios (ORs) with 95% confidence intervals (CIs).RESULTS: After adjustment for smoking and socioeconomic status, patients with rosacea had significantly increased ORs for T1DM (OR 2.59, 95% CI 1.41-4.73), celiac disease (OR 2.03, 95% CI 1.35-3.07), multiple sclerosis (OR 1.65, 95% CI 1.20-2.28), and rheumatoid arthritis (OR 2.14, 95% CI 1.82-2.52). The association was mainly observed in women.LIMITATIONS: We were unable to distinguish between the different subtypes and severities of rosacea.CONCLUSIONS: Rosacea is associated with T1DM, celiac disease, multiple sclerosis, and rheumatoid arthritis, respectively, in women, whereas the association in men only reached statistical significance for rheumatoid arthritis.

KW - Adult

KW - Age Distribution

KW - Autoimmune Diseases

KW - Case-Control Studies

KW - Celiac Disease

KW - Cluster Analysis

KW - Comorbidity

KW - Confidence Intervals

KW - Databases, Factual

KW - Denmark

KW - Diabetes Mellitus, Type 1

KW - Female

KW - Genome-Wide Association Study

KW - Humans

KW - Incidence

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Odds Ratio

KW - Retrospective Studies

KW - Rheumatic Fever

KW - Risk Assessment

KW - Rosacea

KW - Sex Distribution

KW - Young Adult

KW - Comparative Study

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.jaad.2015.11.004

DO - 10.1016/j.jaad.2015.11.004

M3 - Journal article

C2 - 26830864

SN - 0190-9622

VL - 74

SP - 667-72.e1

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

IS - 4

ER -

Clustering of autoimmune diseases in patients with rosacea

Abstract

Keywords

UN SDGs

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