TY - JOUR
T1 - Clinical Evaluation of Synthetic Aperture Harmonic Imaging for Scanning Focal Malignant Liver Lesions
AU - Brandt, Andreas Hjelm
AU - Hemmsen, Martin Christian
AU - Hansen, Peter Møller
AU - Madsen, Signe Sloth
AU - Krohn, Paul Suno
AU - Lange, Theis
AU - Hansen, Kristoffer Lindskov
AU - Jensen, Jørgen Arendt
AU - Nielsen, Michael Bachmann
N1 - Copyright © 2015 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - The purpose of the study was to perform a clinical comparison of synthetic aperture sequential beamforming tissue harmonic imaging (SASB-THI) sequences with a conventional imaging technique, dynamic receive focusing with THI (DRF-THI). Both techniques used pulse inversion and were recorded interleaved using a commercial ultrasound system (UltraView 800, BK Medical, Herlev, Denmark). Thirty-one patients with malignant focal liver lesions (confirmed by biopsy or computed tomography/magnetic resonance) were scanned. Detection of malignant focal liver lesions and preference of image quality were evaluated blinded off-line by eight radiologists. In total, 2,032 evaluations of 127 image sequences were completed. The sensitivity (77% SASB-THI, 76% DRF-THI, p = 0.54) and specificity (71% SASB-THI, 72% DRF-THI, p = 0.67) of detection of liver lesions and the evaluation of image quality (p = 0.63) did not differ between SASB-THI and DRF-THI. This study indicates the ability of SASB-THI in a true clinical setting.
AB - The purpose of the study was to perform a clinical comparison of synthetic aperture sequential beamforming tissue harmonic imaging (SASB-THI) sequences with a conventional imaging technique, dynamic receive focusing with THI (DRF-THI). Both techniques used pulse inversion and were recorded interleaved using a commercial ultrasound system (UltraView 800, BK Medical, Herlev, Denmark). Thirty-one patients with malignant focal liver lesions (confirmed by biopsy or computed tomography/magnetic resonance) were scanned. Detection of malignant focal liver lesions and preference of image quality were evaluated blinded off-line by eight radiologists. In total, 2,032 evaluations of 127 image sequences were completed. The sensitivity (77% SASB-THI, 76% DRF-THI, p = 0.54) and specificity (71% SASB-THI, 72% DRF-THI, p = 0.67) of detection of liver lesions and the evaluation of image quality (p = 0.63) did not differ between SASB-THI and DRF-THI. This study indicates the ability of SASB-THI in a true clinical setting.
U2 - 10.1016/j.ultrasmedbio.2015.05.008
DO - 10.1016/j.ultrasmedbio.2015.05.008
M3 - Journal article
C2 - 26095533
SN - 0301-5629
VL - 41
SP - 2368
EP - 2375
JO - Ultrasound in Medicine & Biology
JF - Ultrasound in Medicine & Biology
IS - 9
ER -