Clinical and neurocognitive markers of suicidality in young adults

Samuel R Chamberlain; Brian Lawrence Odlaug; Liana R N Schreiber; Jon E Grant

doi:10.1016/j.jpsychires.2012.12.016

Clinical and neurocognitive markers of suicidality in young adults

Samuel R Chamberlain, Brian Lawrence Odlaug, Liana R N Schreiber, Jon E Grant

Section of Environmental Health

17 Citations (Scopus)

Abstract

Background: Suicide represents a leading cause of death in young people, yet relatively little is known regarding the neurobiological sequelae of preceding suicidal thoughts and behaviours. Although some studies have reported cognitive deficits associated with suicidality, very few studies have been undertaken in young people, especially from non-clinical contexts. Aims: To quantify cognitive deficits associated with suicidality using a representative sample of young people, recruited from the general community using media advertisements. Method: 304 adults (18-29 years) undertook the Mini-International Neuropsychiatric Inventory (MINI) suicidality module, along with Cambridge Gamble and Stop-Signal tasks. Suicidality was defined as non-zero MINI scores (broad definition) and a past history of suicide attempt(s) (narrow definition). Clinical features and cognitive performance were compared between those with and those without suicidality, using analysis of variance/chi-square; findings were further explored using linear regression. Results: Suicidality was relatively common (broad definition: 14.8%; narrow definition: 5.3%) in young people and was associated with impaired decision-making on the Cambridge Gamble task (p < 0.05, Bonferroni corrected at the analysis level of each suicidality definition). Linear regression demonstrated that decision-making performance was associated with a significant incremental benefit with respect to predicting suicidality, over and above the utility of demographic and clinical variables considered (p < 0.05 uncorrected). Conclusions: Impaired decision-making exists in young people with suicidality, and may thereby predispose towards a range of suicidal thoughts and behaviours. Further work is needed to clarify the chain of progression from such thoughts/behaviours, which are relatively common, through to actual suicide, which is not.

Original language	English
Journal	Journal of Psychiatric Research
Volume	47
Issue number	5
Pages (from-to)	586-91
Number of pages	6
ISSN	0022-3956
DOIs	https://doi.org/10.1016/j.jpsychires.2012.12.016
Publication status	Published - May 2013

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10.1016/j.jpsychires.2012.12.016

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@article{425580b34d694acbb835585d286cc909,

title = "Clinical and neurocognitive markers of suicidality in young adults",

abstract = "Background: Suicide represents a leading cause of death in young people, yet relatively little is known regarding the neurobiological sequelae of preceding suicidal thoughts and behaviours. Although some studies have reported cognitive deficits associated with suicidality, very few studies have been undertaken in young people, especially from non-clinical contexts. Aims: To quantify cognitive deficits associated with suicidality using a representative sample of young people, recruited from the general community using media advertisements. Method: 304 adults (18-29 years) undertook the Mini-International Neuropsychiatric Inventory (MINI) suicidality module, along with Cambridge Gamble and Stop-Signal tasks. Suicidality was defined as non-zero MINI scores (broad definition) and a past history of suicide attempt(s) (narrow definition). Clinical features and cognitive performance were compared between those with and those without suicidality, using analysis of variance/chi-square; findings were further explored using linear regression. Results: Suicidality was relatively common (broad definition: 14.8%; narrow definition: 5.3%) in young people and was associated with impaired decision-making on the Cambridge Gamble task (p < 0.05, Bonferroni corrected at the analysis level of each suicidality definition). Linear regression demonstrated that decision-making performance was associated with a significant incremental benefit with respect to predicting suicidality, over and above the utility of demographic and clinical variables considered (p < 0.05 uncorrected). Conclusions: Impaired decision-making exists in young people with suicidality, and may thereby predispose towards a range of suicidal thoughts and behaviours. Further work is needed to clarify the chain of progression from such thoughts/behaviours, which are relatively common, through to actual suicide, which is not.",

author = "Chamberlain, {Samuel R} and Odlaug, {Brian Lawrence} and Schreiber, {Liana R N} and Grant, {Jon E}",

year = "2013",

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doi = "10.1016/j.jpsychires.2012.12.016",

language = "English",

volume = "47",

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journal = "Journal of Psychiatric Research",

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T1 - Clinical and neurocognitive markers of suicidality in young adults

AU - Chamberlain, Samuel R

AU - Odlaug, Brian Lawrence

AU - Schreiber, Liana R N

AU - Grant, Jon E

PY - 2013/5

Y1 - 2013/5

N2 - Background: Suicide represents a leading cause of death in young people, yet relatively little is known regarding the neurobiological sequelae of preceding suicidal thoughts and behaviours. Although some studies have reported cognitive deficits associated with suicidality, very few studies have been undertaken in young people, especially from non-clinical contexts. Aims: To quantify cognitive deficits associated with suicidality using a representative sample of young people, recruited from the general community using media advertisements. Method: 304 adults (18-29 years) undertook the Mini-International Neuropsychiatric Inventory (MINI) suicidality module, along with Cambridge Gamble and Stop-Signal tasks. Suicidality was defined as non-zero MINI scores (broad definition) and a past history of suicide attempt(s) (narrow definition). Clinical features and cognitive performance were compared between those with and those without suicidality, using analysis of variance/chi-square; findings were further explored using linear regression. Results: Suicidality was relatively common (broad definition: 14.8%; narrow definition: 5.3%) in young people and was associated with impaired decision-making on the Cambridge Gamble task (p < 0.05, Bonferroni corrected at the analysis level of each suicidality definition). Linear regression demonstrated that decision-making performance was associated with a significant incremental benefit with respect to predicting suicidality, over and above the utility of demographic and clinical variables considered (p < 0.05 uncorrected). Conclusions: Impaired decision-making exists in young people with suicidality, and may thereby predispose towards a range of suicidal thoughts and behaviours. Further work is needed to clarify the chain of progression from such thoughts/behaviours, which are relatively common, through to actual suicide, which is not.

AB - Background: Suicide represents a leading cause of death in young people, yet relatively little is known regarding the neurobiological sequelae of preceding suicidal thoughts and behaviours. Although some studies have reported cognitive deficits associated with suicidality, very few studies have been undertaken in young people, especially from non-clinical contexts. Aims: To quantify cognitive deficits associated with suicidality using a representative sample of young people, recruited from the general community using media advertisements. Method: 304 adults (18-29 years) undertook the Mini-International Neuropsychiatric Inventory (MINI) suicidality module, along with Cambridge Gamble and Stop-Signal tasks. Suicidality was defined as non-zero MINI scores (broad definition) and a past history of suicide attempt(s) (narrow definition). Clinical features and cognitive performance were compared between those with and those without suicidality, using analysis of variance/chi-square; findings were further explored using linear regression. Results: Suicidality was relatively common (broad definition: 14.8%; narrow definition: 5.3%) in young people and was associated with impaired decision-making on the Cambridge Gamble task (p < 0.05, Bonferroni corrected at the analysis level of each suicidality definition). Linear regression demonstrated that decision-making performance was associated with a significant incremental benefit with respect to predicting suicidality, over and above the utility of demographic and clinical variables considered (p < 0.05 uncorrected). Conclusions: Impaired decision-making exists in young people with suicidality, and may thereby predispose towards a range of suicidal thoughts and behaviours. Further work is needed to clarify the chain of progression from such thoughts/behaviours, which are relatively common, through to actual suicide, which is not.

U2 - 10.1016/j.jpsychires.2012.12.016

DO - 10.1016/j.jpsychires.2012.12.016

M3 - Journal article

C2 - 23357208

SN - 0022-3956

VL - 47

SP - 586

EP - 591

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

IS - 5

ER -

Clinical and neurocognitive markers of suicidality in young adults

Abstract

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