Circulating angiogenic cytokines and stem cells in patients with severe chronic ischemic heart disease--indicators of myocardial ischemic burden?

Rasmus Sejersten Ripa, Yongzhong Wang, Jens Peter Goetze, Erik Jørgensen, Hans E Johnsen, Kristina Tägil, Birger Hesse, Jens Kastrup

12 Citations (Scopus)

Abstract

Angiogenic growth factors and stem cell therapies have demonstrated varying results in patients with chronic coronary artery disease. A reason could be that these mechanisms are already up-regulated due to reduced blood supply to the myocardium. The objective of this study was to examine if plasma concentrations of circulating stem cells and angiogenic cytokines in patients with severe stable chronic coronary artery disease were correlated to the clinical severity of the disease.
Original languageEnglish
JournalInternational Journal of Cardiology
Volume120
Issue number2
Pages (from-to)181-7
Number of pages7
ISSN0167-5273
DOIs
Publication statusPublished - 21 Aug 2007
Externally publishedYes

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, CD34
  • Antigens, CD45
  • Biological Markers
  • Chronic Disease
  • Cytokines
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Flow Cytometry
  • Follow-Up Studies
  • Humans
  • Male
  • Mesenchymal Stromal Cells
  • Middle Aged
  • Myocardial Ischemia
  • Prospective Studies
  • Radioimmunoassay
  • Severity of Illness Index
  • Stem Cells

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