Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies

Camilla Præstegaard; Allan Jensen; Signe M. Jensen; Thor S.S. Nielsen; Penelope M. Webb; Christina M. Nagle; Anna DeFazio; Estrid Høgdall; Mary Anne Rossing; Jennifer A. Doherty; Kristine G. Wicklund; Marc T. Goodman; Francesmary Modugno; Kirsten Moysich; Roberta B. Ness; Robert Edwards; Keitaro Matsuo; Satoyo Hosono; Ellen L. Goode; Stacey J. Winham; Brooke L. Fridley; Daniel W. Cramer; Kathryn L. Terry; Joellen M. Schildkraut; Andrew Berchuck; Elisa V. Bandera; Lisa E. Paddock; Leon F. Massuger; Nicolas Wentzensen; Paul Pharoah; Honglin Song; Alice Whittemore; Valerie McGuire; Weiva Sieh; Joseph Rothstein; Hoda Anton-Culver; Argyrios Ziogas; Usha Menon; Simon A. Gayther; Susan J. Ramus; Alexandra Gentry-Maharaj; Anna H. Wu; Celeste L. Pearce; Malcolm Pike; Alice W. Lee; Rebecca Sutphen; Jenny Chang-Claude; Harvey A. Risch; Susanne K. Kjaer; on behalf of the Ovarian Cancer Association Consortium

doi:10.1002/ijc.30600

Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies

Camilla Præstegaard, Allan Jensen^*, Signe M. Jensen, Thor S.S. Nielsen, Penelope M. Webb, Christina M. Nagle, Anna DeFazio, Estrid Høgdall, Mary Anne Rossing, Jennifer A. Doherty, Kristine G. Wicklund, Marc T. Goodman, Francesmary Modugno, Kirsten Moysich, Roberta B. Ness, Robert Edwards, Keitaro Matsuo, Satoyo Hosono, Ellen L. Goode, Stacey J. WinhamBrooke L. Fridley, Daniel W. Cramer, Kathryn L. Terry, Joellen M. Schildkraut, Andrew Berchuck, Elisa V. Bandera, Lisa E. Paddock, Leon F. Massuger, Nicolas Wentzensen, Paul Pharoah, Honglin Song, Alice Whittemore, Valerie McGuire, Weiva Sieh, Joseph Rothstein, Hoda Anton-Culver, Argyrios Ziogas, Usha Menon, Simon A. Gayther, Susan J. Ramus, Alexandra Gentry-Maharaj, Anna H. Wu, Celeste L. Pearce, Malcolm Pike, Alice W. Lee, Rebecca Sutphen, Jenny Chang-Claude, Harvey A. Risch, Susanne K. Kjaer, on behalf of the Ovarian Cancer Association Consortium

^*Corresponding author for this work

Department of Clinical Medicine

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Abstract

Cigarette smoking is associated with an increased risk of developing mucinous ovarian tumors but whether it is associated with ovarian cancer survival overall or for the different histotypes is unestablished. Furthermore, it is unknown whether the association between cigarette smoking and survival differs according to strata of ovarian cancer stage at diagnosis. In a large pooled analysis, we evaluated the association between various measures of cigarette smoking and survival among women with epithelial ovarian cancer. We obtained data from 19 case-control studies in the Ovarian Cancer Association Consortium (OCAC), including 9,114 women diagnosed with ovarian cancer. Cox regression models were used to estimate adjusted study-specific hazard ratios (HRs), which were combined into pooled hazard ratios (pHR) with corresponding 95% confidence intervals (CIs) under random effects models. Overall, 5,149 (57%) women died during a median follow-up period of 7.0 years. Among women diagnosed with ovarian cancer, both current (pHR = 1.17, 95% CI: 1.08–1.28) and former smokers (pHR = 1.10, 95% CI: 1.02–1.18) had worse survival compared with never smoking women. In histotype-stratified analyses, associations were observed for mucinous (current smoking: pHR = 1.91, 95% CI: 1.01–3.65) and serous histotypes (current smoking: pHR = 1.11, 95% CI: 1.00–1.23; former smoking: pHR = 1.12, 95% CI: 1.04–1.20). Further, our results suggested that current smoking has a greater impact on survival among women with localized than disseminated disease. The identification of cigarette smoking as a modifiable factor associated with survival has potential clinical importance as a focus area to improve ovarian cancer prognosis.

Original language	English
Journal	International Journal of Cancer
Volume	140
Issue number	11
Pages (from-to)	2422-2435
Number of pages	14
ISSN	0020-7136
DOIs	https://doi.org/10.1002/ijc.30600
Publication status	Published - 1 Jun 2017

Keywords

cigarette smoking
ovarian cancer
pooled analysis
survival

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Præstegaard, C., Jensen, A., Jensen, S. M., Nielsen, T. S. S., Webb, P. M., Nagle, C. M., DeFazio, A., Høgdall, E., Rossing, M. A., Doherty, J. A., Wicklund, K. G., Goodman, M. T., Modugno, F., Moysich, K., Ness, R. B., Edwards, R., Matsuo, K., Hosono, S., Goode, E. L., ... on behalf of the Ovarian Cancer Association Consortium (2017). Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies. International Journal of Cancer, 140(11), 2422-2435. https://doi.org/10.1002/ijc.30600

Præstegaard, C, Jensen, A, Jensen, SM, Nielsen, TSS, Webb, PM, Nagle, CM, DeFazio, A, Høgdall, E, Rossing, MA, Doherty, JA, Wicklund, KG, Goodman, MT, Modugno, F, Moysich, K, Ness, RB, Edwards, R, Matsuo, K, Hosono, S, Goode, EL, Winham, SJ, Fridley, BL, Cramer, DW, Terry, KL, Schildkraut, JM, Berchuck, A, Bandera, EV, Paddock, LE, Massuger, LF, Wentzensen, N, Pharoah, P, Song, H, Whittemore, A, McGuire, V, Sieh, W, Rothstein, J, Anton-Culver, H, Ziogas, A, Menon, U, Gayther, SA, Ramus, SJ, Gentry-Maharaj, A, Wu, AH, Pearce, CL, Pike, M, Lee, AW, Sutphen, R, Chang-Claude, J, Risch, HA, Kjaer, SK & on behalf of the Ovarian Cancer Association Consortium 2017, 'Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies', International Journal of Cancer, vol. 140, no. 11, pp. 2422-2435. https://doi.org/10.1002/ijc.30600

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title = "Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies",

abstract = "Cigarette smoking is associated with an increased risk of developing mucinous ovarian tumors but whether it is associated with ovarian cancer survival overall or for the different histotypes is unestablished. Furthermore, it is unknown whether the association between cigarette smoking and survival differs according to strata of ovarian cancer stage at diagnosis. In a large pooled analysis, we evaluated the association between various measures of cigarette smoking and survival among women with epithelial ovarian cancer. We obtained data from 19 case-control studies in the Ovarian Cancer Association Consortium (OCAC), including 9,114 women diagnosed with ovarian cancer. Cox regression models were used to estimate adjusted study-specific hazard ratios (HRs), which were combined into pooled hazard ratios (pHR) with corresponding 95% confidence intervals (CIs) under random effects models. Overall, 5,149 (57%) women died during a median follow-up period of 7.0 years. Among women diagnosed with ovarian cancer, both current (pHR = 1.17, 95% CI: 1.08–1.28) and former smokers (pHR = 1.10, 95% CI: 1.02–1.18) had worse survival compared with never smoking women. In histotype-stratified analyses, associations were observed for mucinous (current smoking: pHR = 1.91, 95% CI: 1.01–3.65) and serous histotypes (current smoking: pHR = 1.11, 95% CI: 1.00–1.23; former smoking: pHR = 1.12, 95% CI: 1.04–1.20). Further, our results suggested that current smoking has a greater impact on survival among women with localized than disseminated disease. The identification of cigarette smoking as a modifiable factor associated with survival has potential clinical importance as a focus area to improve ovarian cancer prognosis.",

keywords = "cigarette smoking, ovarian cancer, pooled analysis, survival",

author = "Camilla Pr{\ae}stegaard and Allan Jensen and Jensen, {Signe M.} and Nielsen, {Thor S.S.} and Webb, {Penelope M.} and Nagle, {Christina M.} and Anna DeFazio and Estrid H{\o}gdall and Rossing, {Mary Anne} and Doherty, {Jennifer A.} and Wicklund, {Kristine G.} and Goodman, {Marc T.} and Francesmary Modugno and Kirsten Moysich and Ness, {Roberta B.} and Robert Edwards and Keitaro Matsuo and Satoyo Hosono and Goode, {Ellen L.} and Winham, {Stacey J.} and Fridley, {Brooke L.} and Cramer, {Daniel W.} and Terry, {Kathryn L.} and Schildkraut, {Joellen M.} and Andrew Berchuck and Bandera, {Elisa V.} and Paddock, {Lisa E.} and Massuger, {Leon F.} and Nicolas Wentzensen and Paul Pharoah and Honglin Song and Alice Whittemore and Valerie McGuire and Weiva Sieh and Joseph Rothstein and Hoda Anton-Culver and Argyrios Ziogas and Usha Menon and Gayther, {Simon A.} and Ramus, {Susan J.} and Alexandra Gentry-Maharaj and Wu, {Anna H.} and Pearce, {Celeste L.} and Malcolm Pike and Lee, {Alice W.} and Rebecca Sutphen and Jenny Chang-Claude and Risch, {Harvey A.} and Kjaer, {Susanne K.} and {on behalf of the Ovarian Cancer Association Consortium}",

year = "2017",

month = jun,

day = "1",

doi = "10.1002/ijc.30600",

language = "English",

volume = "140",

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T1 - Cigarette smoking is associated with adverse survival among women with ovarian cancer

T2 - Results from a pooled analysis of 19 studies

AU - Præstegaard, Camilla

AU - Jensen, Allan

AU - Jensen, Signe M.

AU - Nielsen, Thor S.S.

AU - Webb, Penelope M.

AU - Nagle, Christina M.

AU - DeFazio, Anna

AU - Høgdall, Estrid

AU - Rossing, Mary Anne

AU - Doherty, Jennifer A.

AU - Wicklund, Kristine G.

AU - Goodman, Marc T.

AU - Modugno, Francesmary

AU - Moysich, Kirsten

AU - Ness, Roberta B.

AU - Edwards, Robert

AU - Matsuo, Keitaro

AU - Hosono, Satoyo

AU - Goode, Ellen L.

AU - Winham, Stacey J.

AU - Fridley, Brooke L.

AU - Cramer, Daniel W.

AU - Terry, Kathryn L.

AU - Schildkraut, Joellen M.

AU - Berchuck, Andrew

AU - Bandera, Elisa V.

AU - Paddock, Lisa E.

AU - Massuger, Leon F.

AU - Wentzensen, Nicolas

AU - Pharoah, Paul

AU - Song, Honglin

AU - Whittemore, Alice

AU - McGuire, Valerie

AU - Sieh, Weiva

AU - Rothstein, Joseph

AU - Anton-Culver, Hoda

AU - Ziogas, Argyrios

AU - Menon, Usha

AU - Gayther, Simon A.

AU - Ramus, Susan J.

AU - Gentry-Maharaj, Alexandra

AU - Wu, Anna H.

AU - Pearce, Celeste L.

AU - Pike, Malcolm

AU - Lee, Alice W.

AU - Sutphen, Rebecca

AU - Chang-Claude, Jenny

AU - Risch, Harvey A.

AU - Kjaer, Susanne K.

AU - on behalf of the Ovarian Cancer Association Consortium

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Cigarette smoking is associated with an increased risk of developing mucinous ovarian tumors but whether it is associated with ovarian cancer survival overall or for the different histotypes is unestablished. Furthermore, it is unknown whether the association between cigarette smoking and survival differs according to strata of ovarian cancer stage at diagnosis. In a large pooled analysis, we evaluated the association between various measures of cigarette smoking and survival among women with epithelial ovarian cancer. We obtained data from 19 case-control studies in the Ovarian Cancer Association Consortium (OCAC), including 9,114 women diagnosed with ovarian cancer. Cox regression models were used to estimate adjusted study-specific hazard ratios (HRs), which were combined into pooled hazard ratios (pHR) with corresponding 95% confidence intervals (CIs) under random effects models. Overall, 5,149 (57%) women died during a median follow-up period of 7.0 years. Among women diagnosed with ovarian cancer, both current (pHR = 1.17, 95% CI: 1.08–1.28) and former smokers (pHR = 1.10, 95% CI: 1.02–1.18) had worse survival compared with never smoking women. In histotype-stratified analyses, associations were observed for mucinous (current smoking: pHR = 1.91, 95% CI: 1.01–3.65) and serous histotypes (current smoking: pHR = 1.11, 95% CI: 1.00–1.23; former smoking: pHR = 1.12, 95% CI: 1.04–1.20). Further, our results suggested that current smoking has a greater impact on survival among women with localized than disseminated disease. The identification of cigarette smoking as a modifiable factor associated with survival has potential clinical importance as a focus area to improve ovarian cancer prognosis.

AB - Cigarette smoking is associated with an increased risk of developing mucinous ovarian tumors but whether it is associated with ovarian cancer survival overall or for the different histotypes is unestablished. Furthermore, it is unknown whether the association between cigarette smoking and survival differs according to strata of ovarian cancer stage at diagnosis. In a large pooled analysis, we evaluated the association between various measures of cigarette smoking and survival among women with epithelial ovarian cancer. We obtained data from 19 case-control studies in the Ovarian Cancer Association Consortium (OCAC), including 9,114 women diagnosed with ovarian cancer. Cox regression models were used to estimate adjusted study-specific hazard ratios (HRs), which were combined into pooled hazard ratios (pHR) with corresponding 95% confidence intervals (CIs) under random effects models. Overall, 5,149 (57%) women died during a median follow-up period of 7.0 years. Among women diagnosed with ovarian cancer, both current (pHR = 1.17, 95% CI: 1.08–1.28) and former smokers (pHR = 1.10, 95% CI: 1.02–1.18) had worse survival compared with never smoking women. In histotype-stratified analyses, associations were observed for mucinous (current smoking: pHR = 1.91, 95% CI: 1.01–3.65) and serous histotypes (current smoking: pHR = 1.11, 95% CI: 1.00–1.23; former smoking: pHR = 1.12, 95% CI: 1.04–1.20). Further, our results suggested that current smoking has a greater impact on survival among women with localized than disseminated disease. The identification of cigarette smoking as a modifiable factor associated with survival has potential clinical importance as a focus area to improve ovarian cancer prognosis.

KW - cigarette smoking

KW - ovarian cancer

KW - pooled analysis

KW - survival

U2 - 10.1002/ijc.30600

DO - 10.1002/ijc.30600

M3 - Journal article

C2 - 28063166

AN - SCOPUS:85017196416

SN - 0020-7136

VL - 140

SP - 2422

EP - 2435

JO - Radiation Oncology Investigations

JF - Radiation Oncology Investigations

IS - 11

ER -

Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies

Abstract

Keywords

UN SDGs

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