Cigarette smoking and risk of Hodgkin lymphoma and its subtypes: a pooled analysis from the International Lymphoma Epidemiology Consortium (InterLymph)

Mads Kamper-Jørgensen; K Rostgaard; S L Glaser; S H Zahm; W Cozen; K E Smedby; S Sanjosé; E T Chang; T Zheng; C La Vecchia; D Serraino; A Monnereau; E V Kane; L Miligi; P Vineis; J J Spinelli; J R McLaughlin; P Pahwa; J A Dosman; M Vornanen; L Foretova; M Maynadie; A Staines; N Becker; A Nieters; P Brennan; P Boffetta; P Cocco; H Hjalgrim

doi:10.1093/annonc/mdt218

Cigarette smoking and risk of Hodgkin lymphoma and its subtypes: a pooled analysis from the International Lymphoma Epidemiology Consortium (InterLymph)

Mads Kamper-Jørgensen, K Rostgaard, S L Glaser, S H Zahm, W Cozen, K E Smedby, S Sanjosé, E T Chang, T Zheng, C La Vecchia, D Serraino, A Monnereau, E V Kane, L Miligi, P Vineis, J J Spinelli, J R McLaughlin, P Pahwa, J A Dosman, M VornanenL Foretova, M Maynadie, A Staines, N Becker, A Nieters, P Brennan, P Boffetta, P Cocco, H Hjalgrim

Section of Social Medicine

37 Citations (Scopus)

Abstract

Background: The etiology of Hodgkin lymphoma (HL) remains incompletely characterized. Studies of the association between smoking and HL have yielded ambiguous results, possibly due to differences between HL subtypes. Patients and methods: Through the InterLymph Consortium, 12 case-control studies regarding cigarette smoking and HL were identified. Pooled analyses on the association between smoking and HL stratified by tumor histology and Epstein-Barr virus (EBV) status were conducted using random effects models adjusted for confounders. Analyses included 3335 HL cases and 14 278 controls. Results: Overall, 54.5% of cases and 57.4% of controls were ever cigarette smokers. Compared with never smokers, ever smokers had an odds ratio (OR) of HL of 1.10 [95% confidence interval (CI) 1.01-1.21]. This increased risk reflected associations with mixed cellularity cHL (OR = 1.60, 95% CI 1.29-1.99) and EBV-positive cHL (OR = 1.81, 95% CI 1.27-2.56) among current smokers, whereas risk of nodular sclerosis (OR = 1.09, 95% CI 0.90-1.32) and EBV-negative HL (OR = 1.02, 95% CI 0.72-1.44) was not increased. Conclusion: These results support the notion of etiologic heterogeneity between HL subtypes, highlighting the need for HL stratification in future studies. Even if not relevant to all subtypes, our study emphasizes that cigarette smoking should be added to the few modifiable HL risk factors identified.

Original language	English
Journal	Annals of oncology : official journal of the European Society for Medical Oncology / ESMO
ISSN	0923-7534
DOIs	https://doi.org/10.1093/annonc/mdt218
Publication status	Published - Sept 2013

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Kamper-Jørgensen, M., Rostgaard, K., Glaser, S. L., Zahm, S. H., Cozen, W., Smedby, K. E., Sanjosé, S., Chang, E. T., Zheng, T., La Vecchia, C., Serraino, D., Monnereau, A., Kane, E. V., Miligi, L., Vineis, P., Spinelli, J. J., McLaughlin, J. R., Pahwa, P., Dosman, J. A., ... Hjalgrim, H. (2013). Cigarette smoking and risk of Hodgkin lymphoma and its subtypes: a pooled analysis from the International Lymphoma Epidemiology Consortium (InterLymph). Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. https://doi.org/10.1093/annonc/mdt218

Cigarette smoking and risk of Hodgkin lymphoma and its subtypes: a pooled analysis from the International Lymphoma Epidemiology Consortium (InterLymph). / Kamper-Jørgensen, Mads; Rostgaard, K; Glaser, S L et al.
In: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO, 09.2013.

Research output: Contribution to journal › Journal article › Research › peer-review

Kamper-Jørgensen, M, Rostgaard, K, Glaser, SL, Zahm, SH, Cozen, W, Smedby, KE, Sanjosé, S, Chang, ET, Zheng, T, La Vecchia, C, Serraino, D, Monnereau, A, Kane, EV, Miligi, L, Vineis, P, Spinelli, JJ, McLaughlin, JR, Pahwa, P, Dosman, JA, Vornanen, M, Foretova, L, Maynadie, M, Staines, A, Becker, N, Nieters, A, Brennan, P, Boffetta, P, Cocco, P & Hjalgrim, H 2013, 'Cigarette smoking and risk of Hodgkin lymphoma and its subtypes: a pooled analysis from the International Lymphoma Epidemiology Consortium (InterLymph)', Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. https://doi.org/10.1093/annonc/mdt218

@article{ce5fae5e7bab454f967bfa5dabdec08c,

title = "Cigarette smoking and risk of Hodgkin lymphoma and its subtypes: a pooled analysis from the International Lymphoma Epidemiology Consortium (InterLymph)",

abstract = "Background: The etiology of Hodgkin lymphoma (HL) remains incompletely characterized. Studies of the association between smoking and HL have yielded ambiguous results, possibly due to differences between HL subtypes. Patients and methods: Through the InterLymph Consortium, 12 case-control studies regarding cigarette smoking and HL were identified. Pooled analyses on the association between smoking and HL stratified by tumor histology and Epstein-Barr virus (EBV) status were conducted using random effects models adjusted for confounders. Analyses included 3335 HL cases and 14 278 controls. Results: Overall, 54.5% of cases and 57.4% of controls were ever cigarette smokers. Compared with never smokers, ever smokers had an odds ratio (OR) of HL of 1.10 [95% confidence interval (CI) 1.01-1.21]. This increased risk reflected associations with mixed cellularity cHL (OR = 1.60, 95% CI 1.29-1.99) and EBV-positive cHL (OR = 1.81, 95% CI 1.27-2.56) among current smokers, whereas risk of nodular sclerosis (OR = 1.09, 95% CI 0.90-1.32) and EBV-negative HL (OR = 1.02, 95% CI 0.72-1.44) was not increased. Conclusion: These results support the notion of etiologic heterogeneity between HL subtypes, highlighting the need for HL stratification in future studies. Even if not relevant to all subtypes, our study emphasizes that cigarette smoking should be added to the few modifiable HL risk factors identified.",

author = "Mads Kamper-J{\o}rgensen and K Rostgaard and Glaser, {S L} and Zahm, {S H} and W Cozen and Smedby, {K E} and S Sanjos{\'e} and Chang, {E T} and T Zheng and {La Vecchia}, C and D Serraino and A Monnereau and Kane, {E V} and L Miligi and P Vineis and Spinelli, {J J} and McLaughlin, {J R} and P Pahwa and Dosman, {J A} and M Vornanen and L Foretova and M Maynadie and A Staines and N Becker and A Nieters and P Brennan and P Boffetta and P Cocco and H Hjalgrim",

year = "2013",

month = sep,

doi = "10.1093/annonc/mdt218",

language = "English",

journal = "Annals of oncology : official journal of the European Society for Medical Oncology / ESMO",

issn = "0923-7534",

publisher = "Oxford University Press",

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TY - JOUR

T1 - Cigarette smoking and risk of Hodgkin lymphoma and its subtypes

T2 - a pooled analysis from the International Lymphoma Epidemiology Consortium (InterLymph)

AU - Kamper-Jørgensen, Mads

AU - Rostgaard, K

AU - Glaser, S L

AU - Zahm, S H

AU - Cozen, W

AU - Smedby, K E

AU - Sanjosé, S

AU - Chang, E T

AU - Zheng, T

AU - La Vecchia, C

AU - Serraino, D

AU - Monnereau, A

AU - Kane, E V

AU - Miligi, L

AU - Vineis, P

AU - Spinelli, J J

AU - McLaughlin, J R

AU - Pahwa, P

AU - Dosman, J A

AU - Vornanen, M

AU - Foretova, L

AU - Maynadie, M

AU - Staines, A

AU - Becker, N

AU - Nieters, A

AU - Brennan, P

AU - Boffetta, P

AU - Cocco, P

AU - Hjalgrim, H

PY - 2013/9

Y1 - 2013/9

N2 - Background: The etiology of Hodgkin lymphoma (HL) remains incompletely characterized. Studies of the association between smoking and HL have yielded ambiguous results, possibly due to differences between HL subtypes. Patients and methods: Through the InterLymph Consortium, 12 case-control studies regarding cigarette smoking and HL were identified. Pooled analyses on the association between smoking and HL stratified by tumor histology and Epstein-Barr virus (EBV) status were conducted using random effects models adjusted for confounders. Analyses included 3335 HL cases and 14 278 controls. Results: Overall, 54.5% of cases and 57.4% of controls were ever cigarette smokers. Compared with never smokers, ever smokers had an odds ratio (OR) of HL of 1.10 [95% confidence interval (CI) 1.01-1.21]. This increased risk reflected associations with mixed cellularity cHL (OR = 1.60, 95% CI 1.29-1.99) and EBV-positive cHL (OR = 1.81, 95% CI 1.27-2.56) among current smokers, whereas risk of nodular sclerosis (OR = 1.09, 95% CI 0.90-1.32) and EBV-negative HL (OR = 1.02, 95% CI 0.72-1.44) was not increased. Conclusion: These results support the notion of etiologic heterogeneity between HL subtypes, highlighting the need for HL stratification in future studies. Even if not relevant to all subtypes, our study emphasizes that cigarette smoking should be added to the few modifiable HL risk factors identified.

AB - Background: The etiology of Hodgkin lymphoma (HL) remains incompletely characterized. Studies of the association between smoking and HL have yielded ambiguous results, possibly due to differences between HL subtypes. Patients and methods: Through the InterLymph Consortium, 12 case-control studies regarding cigarette smoking and HL were identified. Pooled analyses on the association between smoking and HL stratified by tumor histology and Epstein-Barr virus (EBV) status were conducted using random effects models adjusted for confounders. Analyses included 3335 HL cases and 14 278 controls. Results: Overall, 54.5% of cases and 57.4% of controls were ever cigarette smokers. Compared with never smokers, ever smokers had an odds ratio (OR) of HL of 1.10 [95% confidence interval (CI) 1.01-1.21]. This increased risk reflected associations with mixed cellularity cHL (OR = 1.60, 95% CI 1.29-1.99) and EBV-positive cHL (OR = 1.81, 95% CI 1.27-2.56) among current smokers, whereas risk of nodular sclerosis (OR = 1.09, 95% CI 0.90-1.32) and EBV-negative HL (OR = 1.02, 95% CI 0.72-1.44) was not increased. Conclusion: These results support the notion of etiologic heterogeneity between HL subtypes, highlighting the need for HL stratification in future studies. Even if not relevant to all subtypes, our study emphasizes that cigarette smoking should be added to the few modifiable HL risk factors identified.

U2 - 10.1093/annonc/mdt218

DO - 10.1093/annonc/mdt218

M3 - Journal article

C2 - 23788758

SN - 0923-7534

JO - Annals of oncology : official journal of the European Society for Medical Oncology / ESMO

JF - Annals of oncology : official journal of the European Society for Medical Oncology / ESMO

ER -

Cigarette smoking and risk of Hodgkin lymphoma and its subtypes: a pooled analysis from the International Lymphoma Epidemiology Consortium (InterLymph)

Abstract

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