Chronic recreational physical inactivity and epithelial ovarian cancer risk: Evidence from the ovarian cancer association consortium

Rikki Cannioto; Michael J. LaMonte; Harvey A Risch; Chi-chen Hong; Lara E Sucheston-Campbell; Kevin H Eng; J Brian Szender; Jenny Chang-Claude; Barbara Schmalfeldt; Ruediger Klapdor; Emily Gower; Albina N. Minlikeeva; Gary R. Zirpoli; Elisa V Bandera; Andrew Berchuck; Daniel W Cramer; Jennifer A Doherty; Robert P Edwards; Brooke L Fridley; Ellen L Goode; Marc T Goodman; Estrid Hogdall; Satoyo Hosono; Allan Jensen; Susan M Jordan; Susanne K. Kjaer; Keitaro Matsuo; Roberta B Ness; Catherine M Olsen; Sara H Olson; Celeste Leigh Pearce; Malcolm C Pike; Mary Anne Rossing; Elizabeth A. Szamreta; Pamela J Thompson; Chiu-Chen Tseng; Robert A Vierkant; Penelope M Webb; Nicolas Wentzensen; Kristine G Wicklund; Stacey J Winham; Anna H Wu; Francesmary Modugno; Joellen M Schildkraut; Kathryn L Terry; Linda E Kelemen; Kirsten B Moysich

doi:10.1158/1055-9965.epi-15-1330

Chronic recreational physical inactivity and epithelial ovarian cancer risk: Evidence from the ovarian cancer association consortium

Rikki Cannioto, Michael J. LaMonte, Harvey A Risch, Chi-chen Hong, Lara E Sucheston-Campbell, Kevin H Eng, J Brian Szender, Jenny Chang-Claude, Barbara Schmalfeldt, Ruediger Klapdor, Emily Gower, Albina N. Minlikeeva, Gary R. Zirpoli, Elisa V Bandera, Andrew Berchuck, Daniel W Cramer, Jennifer A Doherty, Robert P Edwards, Brooke L Fridley, Ellen L GoodeMarc T Goodman, Estrid Hogdall, Satoyo Hosono, Allan Jensen, Susan M Jordan, Susanne K. Kjaer, Keitaro Matsuo, Roberta B Ness, Catherine M Olsen, Sara H Olson, Celeste Leigh Pearce, Malcolm C Pike, Mary Anne Rossing, Elizabeth A. Szamreta, Pamela J Thompson, Chiu-Chen Tseng, Robert A Vierkant, Penelope M Webb, Nicolas Wentzensen, Kristine G Wicklund, Stacey J Winham, Anna H Wu, Francesmary Modugno, Joellen M Schildkraut, Kathryn L Terry, Linda E Kelemen, Kirsten B Moysich

Department of Clinical Medicine

22 Citations (Scopus)

Abstract

Background: Despite a large body of literature evaluating the association between recreational physical activity and epithelial ovarian cancer (EOC) risk, the extant evidence is inconclusive, and little is known about the independent association between recreational physical inactivity and EOC risk. We conducted a pooled analysis of nine studies from the Ovarian Cancer Association Consortium to investigate the association between chronic recreational physical inactivity and EOC risk. Methods: In accordance with the 2008 Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. Multivariable logistic regression was utilized to estimate the ORs and 95% confidence intervals (CI) for the association between inactivity and EOC risk overall and by subgroups based upon histotype, menopausal status, race, and body mass index. Results: The current analysis included data from 8,309 EOC patients and 12,612 controls. We observed a significant positive association between inactivity and EOC risk (OR = 1.34; 95% CI, 1.14-1.57), and similar associations were observed for each histotype. Conclusions: In this large pooled analysis examining the association between recreational physical inactivity and EOC risk, we observed consistent evidence of an association between chronic inactivity and all EOC histotypes. Impact: These data add to the growing body of evidence suggesting that inactivity is an independent risk factor for cancer. If the apparent association between inactivity and EOC risk is substantiated, additional work via targeted interventions should be pursued to characterize the dose of activity required to mitigate the risk of this highly fatal disease.

Original language	English
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	25
Issue number	7
Pages (from-to)	1114-1124
Number of pages	11
ISSN	1055-9965
DOIs	https://doi.org/10.1158/1055-9965.epi-15-1330
Publication status	Published - 2016

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Cannioto, R., LaMonte, M. J., Risch, H. A., Hong, C., Sucheston-Campbell, L. E., Eng, K. H., Szender, J. B., Chang-Claude, J., Schmalfeldt, B., Klapdor, R., Gower, E., Minlikeeva, A. N., Zirpoli, G. R., Bandera, E. V., Berchuck, A., Cramer, D. W., Doherty, J. A., Edwards, R. P., Fridley, B. L., ... Moysich, K. B. (2016). Chronic recreational physical inactivity and epithelial ovarian cancer risk: Evidence from the ovarian cancer association consortium. Cancer Epidemiology Biomarkers and Prevention, 25(7), 1114-1124. https://doi.org/10.1158/1055-9965.epi-15-1330

Chronic recreational physical inactivity and epithelial ovarian cancer risk : Evidence from the ovarian cancer association consortium. / Cannioto, Rikki; LaMonte, Michael J.; Risch, Harvey A et al.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 25, No. 7, 2016, p. 1114-1124.

Research output: Contribution to journal › Journal article › Research › peer-review

Cannioto, R, LaMonte, MJ, Risch, HA, Hong, C, Sucheston-Campbell, LE, Eng, KH, Szender, JB, Chang-Claude, J, Schmalfeldt, B, Klapdor, R, Gower, E, Minlikeeva, AN, Zirpoli, GR, Bandera, EV, Berchuck, A, Cramer, DW, Doherty, JA, Edwards, RP, Fridley, BL, Goode, EL, Goodman, MT, Hogdall, E, Hosono, S, Jensen, A, Jordan, SM, Kjaer, SK, Matsuo, K, Ness, RB, Olsen, CM, Olson, SH, Pearce, CL, Pike, MC, Rossing, MA, Szamreta, EA, Thompson, PJ, Tseng, C-C, Vierkant, RA, Webb, PM, Wentzensen, N, Wicklund, KG, Winham, SJ, Wu, AH, Modugno, F, Schildkraut, JM, Terry, KL, Kelemen, LE & Moysich, KB 2016, 'Chronic recreational physical inactivity and epithelial ovarian cancer risk: Evidence from the ovarian cancer association consortium', Cancer Epidemiology Biomarkers and Prevention, vol. 25, no. 7, pp. 1114-1124. https://doi.org/10.1158/1055-9965.epi-15-1330

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title = "Chronic recreational physical inactivity and epithelial ovarian cancer risk: Evidence from the ovarian cancer association consortium",

abstract = "Background: Despite a large body of literature evaluating the association between recreational physical activity and epithelial ovarian cancer (EOC) risk, the extant evidence is inconclusive, and little is known about the independent association between recreational physical inactivity and EOC risk. We conducted a pooled analysis of nine studies from the Ovarian Cancer Association Consortium to investigate the association between chronic recreational physical inactivity and EOC risk. Methods: In accordance with the 2008 Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. Multivariable logistic regression was utilized to estimate the ORs and 95% confidence intervals (CI) for the association between inactivity and EOC risk overall and by subgroups based upon histotype, menopausal status, race, and body mass index. Results: The current analysis included data from 8,309 EOC patients and 12,612 controls. We observed a significant positive association between inactivity and EOC risk (OR = 1.34; 95% CI, 1.14-1.57), and similar associations were observed for each histotype. Conclusions: In this large pooled analysis examining the association between recreational physical inactivity and EOC risk, we observed consistent evidence of an association between chronic inactivity and all EOC histotypes. Impact: These data add to the growing body of evidence suggesting that inactivity is an independent risk factor for cancer. If the apparent association between inactivity and EOC risk is substantiated, additional work via targeted interventions should be pursued to characterize the dose of activity required to mitigate the risk of this highly fatal disease.",

author = "Rikki Cannioto and LaMonte, {Michael J.} and Risch, {Harvey A} and Chi-chen Hong and Sucheston-Campbell, {Lara E} and Eng, {Kevin H} and Szender, {J Brian} and Jenny Chang-Claude and Barbara Schmalfeldt and Ruediger Klapdor and Emily Gower and Minlikeeva, {Albina N.} and Zirpoli, {Gary R.} and Bandera, {Elisa V} and Andrew Berchuck and Cramer, {Daniel W} and Doherty, {Jennifer A} and Edwards, {Robert P} and Fridley, {Brooke L} and Goode, {Ellen L} and Goodman, {Marc T} and Estrid Hogdall and Satoyo Hosono and Allan Jensen and Jordan, {Susan M} and Kjaer, {Susanne K.} and Keitaro Matsuo and Ness, {Roberta B} and Olsen, {Catherine M} and Olson, {Sara H} and Pearce, {Celeste Leigh} and Pike, {Malcolm C} and Rossing, {Mary Anne} and Szamreta, {Elizabeth A.} and Thompson, {Pamela J} and Chiu-Chen Tseng and Vierkant, {Robert A} and Webb, {Penelope M} and Nicolas Wentzensen and Wicklund, {Kristine G} and Winham, {Stacey J} and Wu, {Anna H} and Francesmary Modugno and Schildkraut, {Joellen M} and Terry, {Kathryn L} and Kelemen, {Linda E} and Moysich, {Kirsten B}",

year = "2016",

doi = "10.1158/1055-9965.epi-15-1330",

language = "English",

volume = "25",

pages = "1114--1124",

journal = "Cancer Epidemiology, Biomarkers & Prevention",

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TY - JOUR

T1 - Chronic recreational physical inactivity and epithelial ovarian cancer risk

T2 - Evidence from the ovarian cancer association consortium

AU - Cannioto, Rikki

AU - LaMonte, Michael J.

AU - Risch, Harvey A

AU - Hong, Chi-chen

AU - Sucheston-Campbell, Lara E

AU - Eng, Kevin H

AU - Szender, J Brian

AU - Chang-Claude, Jenny

AU - Schmalfeldt, Barbara

AU - Klapdor, Ruediger

AU - Gower, Emily

AU - Minlikeeva, Albina N.

AU - Zirpoli, Gary R.

AU - Bandera, Elisa V

AU - Berchuck, Andrew

AU - Cramer, Daniel W

AU - Doherty, Jennifer A

AU - Edwards, Robert P

AU - Fridley, Brooke L

AU - Goode, Ellen L

AU - Goodman, Marc T

AU - Hogdall, Estrid

AU - Hosono, Satoyo

AU - Jensen, Allan

AU - Jordan, Susan M

AU - Kjaer, Susanne K.

AU - Matsuo, Keitaro

AU - Ness, Roberta B

AU - Olsen, Catherine M

AU - Olson, Sara H

AU - Pearce, Celeste Leigh

AU - Pike, Malcolm C

AU - Rossing, Mary Anne

AU - Szamreta, Elizabeth A.

AU - Thompson, Pamela J

AU - Tseng, Chiu-Chen

AU - Vierkant, Robert A

AU - Webb, Penelope M

AU - Wentzensen, Nicolas

AU - Wicklund, Kristine G

AU - Winham, Stacey J

AU - Wu, Anna H

AU - Modugno, Francesmary

AU - Schildkraut, Joellen M

AU - Terry, Kathryn L

AU - Kelemen, Linda E

AU - Moysich, Kirsten B

PY - 2016

Y1 - 2016

N2 - Background: Despite a large body of literature evaluating the association between recreational physical activity and epithelial ovarian cancer (EOC) risk, the extant evidence is inconclusive, and little is known about the independent association between recreational physical inactivity and EOC risk. We conducted a pooled analysis of nine studies from the Ovarian Cancer Association Consortium to investigate the association between chronic recreational physical inactivity and EOC risk. Methods: In accordance with the 2008 Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. Multivariable logistic regression was utilized to estimate the ORs and 95% confidence intervals (CI) for the association between inactivity and EOC risk overall and by subgroups based upon histotype, menopausal status, race, and body mass index. Results: The current analysis included data from 8,309 EOC patients and 12,612 controls. We observed a significant positive association between inactivity and EOC risk (OR = 1.34; 95% CI, 1.14-1.57), and similar associations were observed for each histotype. Conclusions: In this large pooled analysis examining the association between recreational physical inactivity and EOC risk, we observed consistent evidence of an association between chronic inactivity and all EOC histotypes. Impact: These data add to the growing body of evidence suggesting that inactivity is an independent risk factor for cancer. If the apparent association between inactivity and EOC risk is substantiated, additional work via targeted interventions should be pursued to characterize the dose of activity required to mitigate the risk of this highly fatal disease.

AB - Background: Despite a large body of literature evaluating the association between recreational physical activity and epithelial ovarian cancer (EOC) risk, the extant evidence is inconclusive, and little is known about the independent association between recreational physical inactivity and EOC risk. We conducted a pooled analysis of nine studies from the Ovarian Cancer Association Consortium to investigate the association between chronic recreational physical inactivity and EOC risk. Methods: In accordance with the 2008 Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. Multivariable logistic regression was utilized to estimate the ORs and 95% confidence intervals (CI) for the association between inactivity and EOC risk overall and by subgroups based upon histotype, menopausal status, race, and body mass index. Results: The current analysis included data from 8,309 EOC patients and 12,612 controls. We observed a significant positive association between inactivity and EOC risk (OR = 1.34; 95% CI, 1.14-1.57), and similar associations were observed for each histotype. Conclusions: In this large pooled analysis examining the association between recreational physical inactivity and EOC risk, we observed consistent evidence of an association between chronic inactivity and all EOC histotypes. Impact: These data add to the growing body of evidence suggesting that inactivity is an independent risk factor for cancer. If the apparent association between inactivity and EOC risk is substantiated, additional work via targeted interventions should be pursued to characterize the dose of activity required to mitigate the risk of this highly fatal disease.

U2 - 10.1158/1055-9965.epi-15-1330

DO - 10.1158/1055-9965.epi-15-1330

M3 - Journal article

C2 - 27197285

AN - SCOPUS:84977071152

SN - 1055-9965

VL - 25

SP - 1114

EP - 1124

JO - Cancer Epidemiology, Biomarkers & Prevention

JF - Cancer Epidemiology, Biomarkers & Prevention

IS - 7

ER -

Chronic recreational physical inactivity and epithelial ovarian cancer risk: Evidence from the ovarian cancer association consortium

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