Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium

Rikki Cannioto; Michael J. LaMonte; Harvey A Risch; Chi-chen Hong; Lara E Sucheston-Campbell; Kevin H Eng; J Brian Szender; Jenny Chang-Claude; Barbara Schmalfeldt; Ruediger Klapdor; Emily Gower; Albina N. Minlikeeva; Gary R. Zirpoli; Elisa V Bandera; Andrew Berchuck; Daniel W Cramer; Jennifer A Doherty; Robert P Edwards; Brooke L Fridley; Ellen L Goode; Marc T Goodman; Estrid Hogdall; Satoyo Hosono; Allan Jensen; Susan M Jordan; Susanne K. Kjaer; Keitaro Matsuo; Roberta B Ness; Catherine M Olsen; Sara H Olson; Celeste Leigh Pearce; Malcolm C Pike; Mary Anne Rossing; Elizabeth A. Szamreta; Pamela J Thompson; Chiu-Chen Tseng; Robert A Vierkant; Penelope M Webb; Nicolas Wentzensen; Kristine G Wicklund; Stacey J Winham; Anna H Wu; Francesmary Modugno; Joellen M Schildkraut; Kathryn L Terry; Linda E Kelemen; Kirsten B Moysich; on behalf of the Australian Ovarian Cancer Study Group

doi:10.1097/OGX.0000000000000357

Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium

Rikki Cannioto, Michael J. LaMonte, Harvey A Risch, Chi-chen Hong, Lara E Sucheston-Campbell, Kevin H Eng, J Brian Szender, Jenny Chang-Claude, Barbara Schmalfeldt, Ruediger Klapdor, Emily Gower, Albina N. Minlikeeva, Gary R. Zirpoli, Elisa V Bandera, Andrew Berchuck, Daniel W Cramer, Jennifer A Doherty, Robert P Edwards, Brooke L Fridley, Ellen L GoodeMarc T Goodman, Estrid Hogdall, Satoyo Hosono, Allan Jensen, Susan M Jordan, Susanne K. Kjaer, Keitaro Matsuo, Roberta B Ness, Catherine M Olsen, Sara H Olson, Celeste Leigh Pearce, Malcolm C Pike, Mary Anne Rossing, Elizabeth A. Szamreta, Pamela J Thompson, Chiu-Chen Tseng, Robert A Vierkant, Penelope M Webb, Nicolas Wentzensen, Kristine G Wicklund, Stacey J Winham, Anna H Wu, Francesmary Modugno, Joellen M Schildkraut, Kathryn L Terry, Linda E Kelemen, Kirsten B Moysich, on behalf of the Australian Ovarian Cancer Study Group

Abstract

It is estimated that 5% of women in the United States and 10% to 50% of women worldwide are physically inactive. Previous studies have demonstrated that recreational physical activity is associated with decreased risks of developing breast, colon, and endometrial cancers. The association between physical activity and epithelial ovarian cancer (EOC) is less clear. Despite extensive research, including several epidemiological studies and 2 systematic reviews, insufficient and inconsistent evidence is available to support an independent association between recreational physical activity and risk of EOC. This is largely due to use of common methodology in most studies that overlooks recreational physical inactivity as an independent risk factor for EOC.
The aim of this study was to determine whether self-reported, chronic, recreational physical inactivity is an independent risk factor for increased risk of EOC. Individual-level data were obtained from a pooled analysis of 9 population-based case-control studies from the Ovarian Cancer Association Consortium. Seven of these studies were conducted in the United States and the remaining 2 in Europe. Women who reported no regular, weekly recreational physical activity were classified as inactive, according to the 2008 Physical Activity Guidelines for Americans. The association between physical inactivity exposure and EOC risk overall was assessed using multivariable logistic regression. Subgroup analysis was performed based upon EOC histotype, menopause status, race, and body mass index (BMI).
The combined data set included 8309 EOC patients and 12,612 controls.
Meta-analyses showed a significant positive association between inactivity and EOC risk; the odds ratio was 1.34, with a 95% confidence interval of 1.14 to 1.57. Similar positive associations were observed for each histotype.
These data from a large pooled analysis show consistent evidence of a statistically significant positive association between self-reported, chronic recreational physical inactivity and all EOC histotypes The findings add to the growing body of evidence suggesting that inactivity is an independent risk factor for several types of cancer. If the apparent association between inactivity and EOC risk is confirmed, additional prospective epidemiological studies should be conducted to determine the amount of physical activity (dose response) required to reduce the risk of EOC.

Original language	English
Journal	Obstetrical & Gynecological Survey
Volume	71
Issue number	9
Pages (from-to)	528-530
Number of pages	3
ISSN	0029-7828
DOIs	https://doi.org/10.1097/OGX.0000000000000357
Publication status	Published - 2016

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Cannioto, R., LaMonte, M. J., Risch, H. A., Hong, C., Sucheston-Campbell, L. E., Eng, K. H., Szender, J. B., Chang-Claude, J., Schmalfeldt, B., Klapdor, R., Gower, E., Minlikeeva, A. N., Zirpoli, G. R., Bandera, E. V., Berchuck, A., Cramer, D. W., Doherty, J. A., Edwards, R. P., Fridley, B. L., ... on behalf of the Australian Ovarian Cancer Study Group (2016). Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium. Obstetrical & Gynecological Survey, 71(9), 528-530. https://doi.org/10.1097/OGX.0000000000000357

Cannioto, R, LaMonte, MJ, Risch, HA, Hong, C, Sucheston-Campbell, LE, Eng, KH, Szender, JB, Chang-Claude, J, Schmalfeldt, B, Klapdor, R, Gower, E, Minlikeeva, AN, Zirpoli, GR, Bandera, EV, Berchuck, A, Cramer, DW, Doherty, JA, Edwards, RP, Fridley, BL, Goode, EL, Goodman, MT, Hogdall, E, Hosono, S, Jensen, A, Jordan, SM, Kjaer, SK, Matsuo, K, Ness, RB, Olsen, CM, Olson, SH, Pearce, CL, Pike, MC, Rossing, MA, Szamreta, EA, Thompson, PJ, Tseng, C-C, Vierkant, RA, Webb, PM, Wentzensen, N, Wicklund, KG, Winham, SJ, Wu, AH, Modugno, F, Schildkraut, JM, Terry, KL, Kelemen, LE, Moysich, KB & on behalf of the Australian Ovarian Cancer Study Group 2016, 'Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium', Obstetrical & Gynecological Survey, vol. 71, no. 9, pp. 528-530. https://doi.org/10.1097/OGX.0000000000000357

@article{bf8450ae22064a93946751f4cb9f32d4,

title = "Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium",

abstract = "It is estimated that 5% of women in the United States and 10% to 50% of women worldwide are physically inactive. Previous studies have demonstrated that recreational physical activity is associated with decreased risks of developing breast, colon, and endometrial cancers. The association between physical activity and epithelial ovarian cancer (EOC) is less clear. Despite extensive research, including several epidemiological studies and 2 systematic reviews, insufficient and inconsistent evidence is available to support an independent association between recreational physical activity and risk of EOC. This is largely due to use of common methodology in most studies that overlooks recreational physical inactivity as an independent risk factor for EOC.The aim of this study was to determine whether self-reported, chronic, recreational physical inactivity is an independent risk factor for increased risk of EOC. Individual-level data were obtained from a pooled analysis of 9 population-based case-control studies from the Ovarian Cancer Association Consortium. Seven of these studies were conducted in the United States and the remaining 2 in Europe. Women who reported no regular, weekly recreational physical activity were classified as inactive, according to the 2008 Physical Activity Guidelines for Americans. The association between physical inactivity exposure and EOC risk overall was assessed using multivariable logistic regression. Subgroup analysis was performed based upon EOC histotype, menopause status, race, and body mass index (BMI).The combined data set included 8309 EOC patients and 12,612 controls.Meta-analyses showed a significant positive association between inactivity and EOC risk; the odds ratio was 1.34, with a 95% confidence interval of 1.14 to 1.57. Similar positive associations were observed for each histotype.These data from a large pooled analysis show consistent evidence of a statistically significant positive association between self-reported, chronic recreational physical inactivity and all EOC histotypes The findings add to the growing body of evidence suggesting that inactivity is an independent risk factor for several types of cancer. If the apparent association between inactivity and EOC risk is confirmed, additional prospective epidemiological studies should be conducted to determine the amount of physical activity (dose response) required to reduce the risk of EOC.",

author = "Rikki Cannioto and LaMonte, {Michael J.} and Risch, {Harvey A} and Chi-chen Hong and Sucheston-Campbell, {Lara E} and Eng, {Kevin H} and Szender, {J Brian} and Jenny Chang-Claude and Barbara Schmalfeldt and Ruediger Klapdor and Emily Gower and Minlikeeva, {Albina N.} and Zirpoli, {Gary R.} and Bandera, {Elisa V} and Andrew Berchuck and Cramer, {Daniel W} and Doherty, {Jennifer A} and Edwards, {Robert P} and Fridley, {Brooke L} and Goode, {Ellen L} and Goodman, {Marc T} and Estrid Hogdall and Satoyo Hosono and Allan Jensen and Jordan, {Susan M} and Kjaer, {Susanne K.} and Keitaro Matsuo and Ness, {Roberta B} and Olsen, {Catherine M} and Olson, {Sara H} and Pearce, {Celeste Leigh} and Pike, {Malcolm C} and Rossing, {Mary Anne} and Szamreta, {Elizabeth A.} and Thompson, {Pamela J} and Chiu-Chen Tseng and Vierkant, {Robert A} and Webb, {Penelope M} and Nicolas Wentzensen and Wicklund, {Kristine G} and Winham, {Stacey J} and Wu, {Anna H} and Francesmary Modugno and Schildkraut, {Joellen M} and Terry, {Kathryn L} and Kelemen, {Linda E} and Moysich, {Kirsten B} and {on behalf of the Australian Ovarian Cancer Study Group}",

year = "2016",

doi = "10.1097/OGX.0000000000000357",

language = "English",

volume = "71",

pages = "528--530",

journal = "Obstetrical & Gynecological Survey",

issn = "0029-7828",

publisher = "Lippincott Williams & Wilkins",

number = "9",

}

TY - JOUR

T1 - Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk

T2 - Evidence from the Ovarian Cancer Association Consortium

AU - Cannioto, Rikki

AU - LaMonte, Michael J.

AU - Risch, Harvey A

AU - Hong, Chi-chen

AU - Sucheston-Campbell, Lara E

AU - Eng, Kevin H

AU - Szender, J Brian

AU - Chang-Claude, Jenny

AU - Schmalfeldt, Barbara

AU - Klapdor, Ruediger

AU - Gower, Emily

AU - Minlikeeva, Albina N.

AU - Zirpoli, Gary R.

AU - Bandera, Elisa V

AU - Berchuck, Andrew

AU - Cramer, Daniel W

AU - Doherty, Jennifer A

AU - Edwards, Robert P

AU - Fridley, Brooke L

AU - Goode, Ellen L

AU - Goodman, Marc T

AU - Hogdall, Estrid

AU - Hosono, Satoyo

AU - Jensen, Allan

AU - Jordan, Susan M

AU - Kjaer, Susanne K.

AU - Matsuo, Keitaro

AU - Ness, Roberta B

AU - Olsen, Catherine M

AU - Olson, Sara H

AU - Pearce, Celeste Leigh

AU - Pike, Malcolm C

AU - Rossing, Mary Anne

AU - Szamreta, Elizabeth A.

AU - Thompson, Pamela J

AU - Tseng, Chiu-Chen

AU - Vierkant, Robert A

AU - Webb, Penelope M

AU - Wentzensen, Nicolas

AU - Wicklund, Kristine G

AU - Winham, Stacey J

AU - Wu, Anna H

AU - Modugno, Francesmary

AU - Schildkraut, Joellen M

AU - Terry, Kathryn L

AU - Kelemen, Linda E

AU - Moysich, Kirsten B

AU - on behalf of the Australian Ovarian Cancer Study Group

PY - 2016

Y1 - 2016

N2 - It is estimated that 5% of women in the United States and 10% to 50% of women worldwide are physically inactive. Previous studies have demonstrated that recreational physical activity is associated with decreased risks of developing breast, colon, and endometrial cancers. The association between physical activity and epithelial ovarian cancer (EOC) is less clear. Despite extensive research, including several epidemiological studies and 2 systematic reviews, insufficient and inconsistent evidence is available to support an independent association between recreational physical activity and risk of EOC. This is largely due to use of common methodology in most studies that overlooks recreational physical inactivity as an independent risk factor for EOC.The aim of this study was to determine whether self-reported, chronic, recreational physical inactivity is an independent risk factor for increased risk of EOC. Individual-level data were obtained from a pooled analysis of 9 population-based case-control studies from the Ovarian Cancer Association Consortium. Seven of these studies were conducted in the United States and the remaining 2 in Europe. Women who reported no regular, weekly recreational physical activity were classified as inactive, according to the 2008 Physical Activity Guidelines for Americans. The association between physical inactivity exposure and EOC risk overall was assessed using multivariable logistic regression. Subgroup analysis was performed based upon EOC histotype, menopause status, race, and body mass index (BMI).The combined data set included 8309 EOC patients and 12,612 controls.Meta-analyses showed a significant positive association between inactivity and EOC risk; the odds ratio was 1.34, with a 95% confidence interval of 1.14 to 1.57. Similar positive associations were observed for each histotype.These data from a large pooled analysis show consistent evidence of a statistically significant positive association between self-reported, chronic recreational physical inactivity and all EOC histotypes The findings add to the growing body of evidence suggesting that inactivity is an independent risk factor for several types of cancer. If the apparent association between inactivity and EOC risk is confirmed, additional prospective epidemiological studies should be conducted to determine the amount of physical activity (dose response) required to reduce the risk of EOC.

AB - It is estimated that 5% of women in the United States and 10% to 50% of women worldwide are physically inactive. Previous studies have demonstrated that recreational physical activity is associated with decreased risks of developing breast, colon, and endometrial cancers. The association between physical activity and epithelial ovarian cancer (EOC) is less clear. Despite extensive research, including several epidemiological studies and 2 systematic reviews, insufficient and inconsistent evidence is available to support an independent association between recreational physical activity and risk of EOC. This is largely due to use of common methodology in most studies that overlooks recreational physical inactivity as an independent risk factor for EOC.The aim of this study was to determine whether self-reported, chronic, recreational physical inactivity is an independent risk factor for increased risk of EOC. Individual-level data were obtained from a pooled analysis of 9 population-based case-control studies from the Ovarian Cancer Association Consortium. Seven of these studies were conducted in the United States and the remaining 2 in Europe. Women who reported no regular, weekly recreational physical activity were classified as inactive, according to the 2008 Physical Activity Guidelines for Americans. The association between physical inactivity exposure and EOC risk overall was assessed using multivariable logistic regression. Subgroup analysis was performed based upon EOC histotype, menopause status, race, and body mass index (BMI).The combined data set included 8309 EOC patients and 12,612 controls.Meta-analyses showed a significant positive association between inactivity and EOC risk; the odds ratio was 1.34, with a 95% confidence interval of 1.14 to 1.57. Similar positive associations were observed for each histotype.These data from a large pooled analysis show consistent evidence of a statistically significant positive association between self-reported, chronic recreational physical inactivity and all EOC histotypes The findings add to the growing body of evidence suggesting that inactivity is an independent risk factor for several types of cancer. If the apparent association between inactivity and EOC risk is confirmed, additional prospective epidemiological studies should be conducted to determine the amount of physical activity (dose response) required to reduce the risk of EOC.

U2 - 10.1097/OGX.0000000000000357

DO - 10.1097/OGX.0000000000000357

M3 - Comment/debate

AN - SCOPUS:84987707837

SN - 0029-7828

VL - 71

SP - 528

EP - 530

JO - Obstetrical & Gynecological Survey

JF - Obstetrical & Gynecological Survey

IS - 9

ER -

Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium

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