Chronic mucus hypersecretion: prevalence and risk factors in younger individuals

TY - JOUR

T1 - Chronic mucus hypersecretion: prevalence and risk factors in younger individuals

AU - Harmsen, Lotte

AU - Thomsen, S F

AU - Ingebrigtsen, Truls

AU - Steffensen, I E

AU - Skadhauge, L R

AU - Kyvik, K O

AU - Backer, Vibeke

PY - 2010/8/1

Y1 - 2010/8/1

N2 - SETTING: Chronic mucus hypersecretion (CMH) is a common condition in patients with chronic respiratory diseases. Little is known about the incidence, prevalence and determinants of CMH in younger individuals. OBJECTIVE: To determine prevalence, incidence and risk factors for CMH in a young general population. DESIGN: A cohort of Danish twins (aged 12-41 years) was prospectively examined using questionnaires in 1994 (n = 29 180) and in 2002 (n = 21 130). Prevalence and incidence of CMH were determined, and risk factors for the condition were assessed using logistic regression. RESULTS: Lifetime prevalence of CMH was 8.6% in females and 6.9% in males in 1994, and the cumulative incidence among females and males was respectively 10.7% and 8.7% during the study period. Smoking and asthma were risk factors for CMH, with a dose-response effect of tobacco consumption, and smoking habits also predicting incidence of CMH. CONCLUSION: Among the young, CMH is a condition related to asthma and smoking, with a dose-response relationship with tobacco consumption and a relation between smoking habits and incidence. Female susceptibility to d evelopment of CMH was observed, as well as signs of greater susceptibility related to young age.

AB - SETTING: Chronic mucus hypersecretion (CMH) is a common condition in patients with chronic respiratory diseases. Little is known about the incidence, prevalence and determinants of CMH in younger individuals. OBJECTIVE: To determine prevalence, incidence and risk factors for CMH in a young general population. DESIGN: A cohort of Danish twins (aged 12-41 years) was prospectively examined using questionnaires in 1994 (n = 29 180) and in 2002 (n = 21 130). Prevalence and incidence of CMH were determined, and risk factors for the condition were assessed using logistic regression. RESULTS: Lifetime prevalence of CMH was 8.6% in females and 6.9% in males in 1994, and the cumulative incidence among females and males was respectively 10.7% and 8.7% during the study period. Smoking and asthma were risk factors for CMH, with a dose-response effect of tobacco consumption, and smoking habits also predicting incidence of CMH. CONCLUSION: Among the young, CMH is a condition related to asthma and smoking, with a dose-response relationship with tobacco consumption and a relation between smoking habits and incidence. Female susceptibility to d evelopment of CMH was observed, as well as signs of greater susceptibility related to young age.

M3 - Journal article

SN - 1027-3719

VL - 14

SP - 1052

EP - 1058

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

IS - 8

ER -