Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation

TY - JOUR

T1 - Chronic inflammation

T2 - importance of NOD2 and NALP3 in interleukin-1beta generation

AU - Ferrero-Miliani, L

AU - Nielsen, O H

AU - Andersen, P S

AU - Girardin, S E

PY - 2007/2

Y1 - 2007/2

N2 - Inflammation is part of the non-specific immune response that occurs in reaction to any type of bodily injury. In some disorders, the inflammatory process - which under normal conditions is self-limiting - becomes continuous and chronic inflammatory diseases might develop subsequently. Pattern recognition molecules (PRMs) represent a diverse collection of molecules responsible for sensing danger signals, and together with other immune components they are involved in the first line of defence. NALP3 and NOD2, which belong to a cytosolic subgroup of PRMs, dubbed Nod-like-receptors (NLRs), have been associated recently with inflammatory diseases, specifically Crohn's disease and Blau syndrome (NOD2) and familial cold autoinflammatory syndrome, Muckle-Wells syndrome and chronic infantile neurological cutaneous and articular syndrome (NALP3). The exact effects of the defective proteins are not fully understood, but activation of nuclear factor (NF)-kappaB, transcription, production and secretion of interleukin (IL)-1beta and activation of the inflammasome are some of the processes that might hold clues, and the present review will provide a thorough update in this area.

AB - Inflammation is part of the non-specific immune response that occurs in reaction to any type of bodily injury. In some disorders, the inflammatory process - which under normal conditions is self-limiting - becomes continuous and chronic inflammatory diseases might develop subsequently. Pattern recognition molecules (PRMs) represent a diverse collection of molecules responsible for sensing danger signals, and together with other immune components they are involved in the first line of defence. NALP3 and NOD2, which belong to a cytosolic subgroup of PRMs, dubbed Nod-like-receptors (NLRs), have been associated recently with inflammatory diseases, specifically Crohn's disease and Blau syndrome (NOD2) and familial cold autoinflammatory syndrome, Muckle-Wells syndrome and chronic infantile neurological cutaneous and articular syndrome (NALP3). The exact effects of the defective proteins are not fully understood, but activation of nuclear factor (NF)-kappaB, transcription, production and secretion of interleukin (IL)-1beta and activation of the inflammasome are some of the processes that might hold clues, and the present review will provide a thorough update in this area.

KW - Carrier Proteins/immunology

KW - Chronic Disease

KW - Crohn Disease/immunology

KW - Humans

KW - Inflammation/immunology

KW - Interleukin-1beta/biosynthesis

KW - NLR Family, Pyrin Domain-Containing 3 Protein

KW - Nod2 Signaling Adaptor Protein/immunology

KW - Signal Transduction/immunology

U2 - 10.1111/j.1365-2249.2006.03261.x

DO - 10.1111/j.1365-2249.2006.03261.x

M3 - Review

C2 - 17223962

SN - 0009-9104

VL - 147

SP - 227

EP - 235

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

IS - 2

ER -